公开(公告)号：US20220082561A1

公开(公告)日：2022-03-17

申请号：US17276329

申请日：2019-09-20

Applicant: Worcester Polytechnic Institute

Inventor： Seyed Masoud Loeian ,  Balaji Panchapakesan

IPC: G01N33/551 ,  G01N1/40 ,  G01N33/574

Abstract: Methods and devices are provided for the detection and characterization of circulating cells in a blood sample. Such method can include depositing a sample of a bodily fluid on a device comprising carbon nanotubes, wherein the surfaces of the carbon nanotubes are not functionalized; and detecting target cells adhered to the carbon nanotubes.

公开(公告)号：US11273236B2

公开(公告)日：2022-03-15

申请号：US15698429

申请日：2017-09-07

Applicant: Case Western Reserve University ,  Worcester Polytechnic Institute

Inventor： Eben Alsberg ,  Anna D. Dikina ,  Marsha W. Rolle ,  Hannah A. Strobel

IPC: A61L27/38 ,  A61K35/42 ,  A61L27/58 ,  A61K35/32 ,  A61K35/44 ,  A61L27/54 ,  A61K35/28 ,  C12N5/071 ,  C12N5/077 ,  C12M1/12 ,  C12M3/00

Abstract: A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents.

公开(公告)号：US20210391606A1

公开(公告)日：2021-12-16

申请号：US17412742

申请日：2021-08-26

Applicant: Worcester Polytechnic Institute

Inventor： Yan Wang ,  Eric Gratz ,  Qina Sa ,  Zhangfeng Zheng ,  Joseph Heelan ,  Kee-Chan Kim

IPC: H01M10/54 ,  C22B3/00 ,  C22B7/00 ,  C22B1/24 ,  C22B26/22

Abstract: Cathode material from exhausted lithium ion batteries are dissolved in a solution for extracting the useful elements Co (cobalt), Ni (nickel), Al (Aluminum) and Mn (manganese) to produce active cathode materials for new batteries. The solution includes compounds of desirable materials such as cobalt, nickel, aluminum and manganese dissolved as compounds from the exhausted cathode material of spent cells. Depending on a desired proportion, or ratio, of the desired materials, raw materials are added to the solution to achieve the desired ratio of the commingled compounds for the recycled cathode material for new cells. The desired materials precipitate out of solution without extensive heating or separation of the desired materials into individual compounds or elements. The resulting active cathode material has the predetermined ratio for use in new cells, and avoids high heat typically required to separate the useful elements because the desired materials remain commingled in solution.

公开(公告)号：US20210338252A1

公开(公告)日：2021-11-04

申请号：US17244825

申请日：2021-04-29

Applicant: Worcester Polytechnic institute

Inventor： Jesse Kauffman ,  Karim A. Tarabein ,  Cameron W. Downey

IPC: A61B17/16 ,  A61B17/3213

Abstract: A surgical rongeur device has an interchangeable, locking tip at a cutting end for engageable replacement with a variety of cutting tips for facilitating sterilization and blade changes. A detachable linkage between a handle portion and an interchangeable cutting tip (tip) provides a strong connection for actuation by the handle end but allowing for tip replacement via slidable, lateral displacement of the tip. The tip includes a blade and footplate formed from an amorphous metal for longevity and strength advantages. A handle provides a lever to actuate the tip from slidable communication via the detachable linkage. An interlocking member extends longitudinally from the handle into an internal slot on the tip for locking the tip by preventing lateral movement out of alignment with the handle. The aligned tip is responsive to actuation from the handle via a rail for disposing the blade longitudinally against the footplate.

公开(公告)号：US11127992B2

公开(公告)日：2021-09-21

申请号：US16164952

申请日：2018-10-19

Applicant: Worcester Polytechnic Institute

Inventor： Yan Wang ,  Eric Gratz ,  Qina Sa ,  Zhangfeng Zheng ,  Joseph Heelan

IPC: H01M10/54 ,  H01M4/505 ,  H01M10/0525 ,  C22B7/00 ,  C01G53/00 ,  C22B26/12 ,  C22B3/02 ,  H01M4/525 ,  C01D15/08 ,  C22B3/00 ,  C22B47/00 ,  C01G3/02 ,  C01F7/42 ,  C01G49/02

Abstract: Cathode material from exhausted lithium ion batteries are dissolved in a solution for extracting the useful elements Co (cobalt), Ni (nickel), Al (Aluminum) and Mn (manganese) to produce active cathode materials for new batteries. The solution includes compounds of desirable materials such as cobalt, nickel, aluminum and manganese dissolved as compounds from the exhausted cathode material of spent cells. Depending on a desired proportion, or ratio, of the desired materials, raw materials are added to the solution to achieve the desired ratio of the commingled compounds for the recycled cathode material for new cells. The desired materials precipitate out of solution without extensive heating or separation of the desired materials into individual compounds or elements. The resulting active cathode material has the predetermined ratio for use in new cells, and avoids high heat typically required to separate the useful elements because the desired materials remain commingled in solution.

公开(公告)号：US11110203B2

公开(公告)日：2021-09-07

申请号：US16548510

申请日：2019-08-22

Applicant: Worcester Polytechnic Institute

Inventor： Jeannine Coburn ,  Glenn Gaudette ,  Nhi Phan

IPC: C12N5/00 ,  A61L27/36

Abstract: Provided herein are enzymatically decellularized cells, and methods of producing said cells, that can be used in a scaffold. The scaffolds featured herein are biocompatible and can comprise decellularized cells that have been modified to express a bioactive agent or molecule.

公开(公告)号：US11097430B2

公开(公告)日：2021-08-24

申请号：US16176138

申请日：2018-10-31

Applicant: Worcester Polytechnic Institute

Inventor： Cagdas D. Onal ,  Onder Ondemir ,  Weijia Tao

IPC: B25J15/10 ,  B25J15/12 ,  B25J9/00 ,  B25J9/10

Abstract: A soft bodied robotic member has the appearance of a finger and has a deformable rubber elongated body surrounding an array of rigid ribs interconnected by a perpendicular constraint. The plates form a series of parallel protrusions extending from opposed sides of the body and have a serrated, sawtooth or wavelike appearance. A tether runs through each row of protrusions and draws the corresponding protrusions together in a compressive manner to bend or dispose the finger toward the compressed side. Gaps between the protrusion allow movement of the protrusion towards adjacent protrusions to dispose the body in an arcuate shape. The constraint is a planar sheet that bends with the arc along its width, but resists lateral twisting, thus limiting movement outside a plane defined by the arc and the tether. Multiple finger members may be placed in close geometric proximity for gripping a common object.

公开(公告)号：US20210128674A1

公开(公告)日：2021-05-06

申请号：US17085861

申请日：2020-10-30

Applicant: Worcester Polytechnic Institute

Inventor： Winston O. Soboyejo ,  John D. Obayemi ,  Ali A. Salifu ,  Vanessa O. Uzonwanne

IPC: A61K38/09 ,  A61K31/4025 ,  A61K47/55 ,  A61K47/64 ,  A61K47/54 ,  A61K9/50 ,  A61P35/00 ,  A61K9/00

Abstract: Aspects of the disclosure relate to compositions comprising Luteinizing Hormone Releasing Hormone (LHRH) or an analog of LHRH conjugated to prodigiosin, and methods of treatment of cancer, for example, triple negative breast cancer, using such compositions.

公开(公告)号：US10945658B2

公开(公告)日：2021-03-16

申请号：US15956830

申请日：2018-04-19

Applicant: Worcester Polytechnic Institute ,  Beth Israel Deaconess Medical Center, Inc.

Inventor： Karen L. Troy ,  John J. Wixted ,  Ara Nazarian

IPC: A61B5/00 ,  A61B6/00 ,  A61B6/03 ,  A61B5/103 ,  A61B5/055 ,  G06T7/00 ,  A61B5/1495

Abstract: In some embodiments, there is provide a method of analysing a bone fracture, comprising; stabilizing a bone having a fracture including a first support point located distal of the fracture and a second support point located proximal of the fracture; applying a force to an area of the bone having the fracture to cause a displacement of the fracture; imaging the bone during the application of force thereto; and comparing the image of the bone during the application of force to an image of the bone without the application of force to determine the state of the fracture.

公开(公告)号：US10945636B2

公开(公告)日：2021-03-16

申请号：US15916628

申请日：2018-03-09

Applicant: Worcester Polytechnic Institute

Inventor： Lucy Garvey ,  Lubna Hassan ,  Kyla Nichols ,  Allison Paquin ,  Robert J. Daniello

IPC: A61B5/08 ,  A61B5/087 ,  A61B5/085 ,  A61B5/091 ,  A61B5/113

Abstract: An equine respiratory detection device provides an inexpensive, portable appliance for evaluating equine health. A muzzle or mouthpiece attaches to the equine mouth region for sealably engaging with the respiratory pathway. The mouthpiece attached to a tubular vessel having a volumetric sensing apparatus for measuring respiratory inflow and outflow rates. The sensing apparatus includes a hot wire anemometer and sensing circuit for sensing flow rates based on changing electrical characteristics of a sensing element resulting from a temperature and humidity of the respiratory gases. Inhaling results in inflow gases having a cooling effect on a thermistor which affects the current flow in the sensor circuit. Similarly, exhaled outflow gases have increased temperature and humidity which allow identification of bidirectional flow and computation of an overall respiration volume to the equine patient subject.