公开(公告)号：US20170299530A1

公开(公告)日：2017-10-19

申请号：US15640757

申请日：2017-07-03

Applicant: ACADEMIA SINICA

Inventor： Wen-Bin YANG

IPC: G01N24/08 ,  G01N33/02 ,  G01N33/14 ,  G01N33/50

CPC classification number: G01N24/087 ,  C07D233/64 ,  C07D241/44 ,  C07H3/02 ,  C07H7/06 ,  C07H13/02 ,  G01N33/025 ,  G01N33/143 ,  G01N33/50 ,  G01N33/58 ,  G01N2400/00 ,  G01N2458/00 ,  G01N2458/15

Abstract: Provided is a method for quantitating a saccharide in a liquid sample. The method comprises incubating the liquid sample with 2,3-naphthalenediamine in the presence of iodine to allow a naphthimidazole group to be linked to the saccharide to obtain a first mixture; obtaining an 1H-NMR spectrum of the first mixture; and comparing, in said 1H-NMR spectrum, the intensity or integral of a proton signal corresponding to the saccharide to the intensity or integral of a proton signal corresponding to an internal standard present in the first mixture.

公开(公告)号：US09782476B2

公开(公告)日：2017-10-10

申请号：US14480521

申请日：2014-09-08

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Alice L. Yu ,  Kun-Hsien Lin ,  Tai-Na Wu

IPC: C07H15/18 ,  A61K39/39 ,  A61K31/7032 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K2039/55511 ,  A61K2039/57 ,  C07H15/18

Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.

公开(公告)号：US09771589B2

公开(公告)日：2017-09-26

申请号：US15023284

申请日：2014-09-19

Applicant: Academia Sinica

Inventor： Chiaho Shih ,  Jyun-Yuan Huang

IPC: C12N15/113 ,  C12N7/00 ,  A61K31/7088 ,  A61K45/06

CPC classification number: C12N15/1131 ,  A61K31/7088 ,  A61K45/06 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2730/10111

Abstract: Methods and pharmaceutical compositions for regulating hepatitis virus replication, involving a miR-130a RNA, a miR-130b RNA, a miR-204 RNA, a miR-1236 RNA, or a combination thereof.

公开(公告)号：US20170233658A1

公开(公告)日：2017-08-17

申请号：US15309707

申请日：2015-05-07

Applicant: Frank H. SHU ,  Academia Sinica

Inventor： Frank H. SHU ,  Fen-Tair LUO ,  Michael J. CAI

IPC: C10B49/14 ,  C10B39/06 ,  C10L9/08 ,  C10B57/18 ,  C10L5/44 ,  C10B53/02 ,  C10B53/08

CPC classification number: C10B49/14 ,  C10B39/06 ,  C10B53/02 ,  C10B53/08 ,  C10B57/18 ,  C10L5/44 ,  C10L5/447 ,  C10L9/083 ,  C10L2290/06 ,  Y02E50/10 ,  Y02E50/14 ,  Y02E50/15 ,  Y02E50/30

Abstract: A compact, transportable batch-process supertorrefaction system includes at least one supertorrefying unit, a liquid tank containing molten salt, and a wash tank including a plurality of basins containing water having different temperatures and different salinity. The liquid tank and the wash tank sequentially supply the molten salt and the water to a receiving space of the at least one supertorrefying unit to supertorrefy the biomass into charcoal and to rinse and cool the charcoal, respectively. The plurality of basins of the wash unit sequentially supply water having different temperatures and salinity to the same receiving space to gradually rinse and cool the charcoal. The biomass is not moved in the at least one supertorrfeying unit during biomass supertorrefaction. The charcoal is not moved during charcoal cooling.

公开(公告)号：US20170226169A1

公开(公告)日：2017-08-10

申请号：US15328593

申请日：2015-07-24

Applicant: Academia Sinica

Inventor： Benjamin Pang-hsien Tu ,  Rita PY Chen ,  Joseph Jen-Tse Huang ,  Yijuang Chern ,  Yu-Song Jang ,  Xiang-Me Lai ,  Tai-Yan Liao ,  Te-Hsien Kung

IPC: C07K14/47

CPC classification number: C07K14/4711 ,  A61K38/00 ,  C07K14/4703 ,  C07K2319/00

Abstract: Bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate and treating diseases associated with such abnormal protein aggregate, including neurodegenerative disease characterized by formation of protein aggregates.

公开(公告)号：US20170224716A1

公开(公告)日：2017-08-10

申请号：US15376281

申请日：2016-12-12

Applicant: Academia Sinica

Inventor： Chih-Cheng Chen ,  Yun-Lian Lin ,  Jim-Min Fang ,  Yijuang Chern ,  Chia-Ching John Lin ,  Wei-Nan Chen ,  Chun-Jung Lin

IPC: A61K31/7076 ,  A61K45/06 ,  A61K36/8988

CPC classification number: A61K31/7076 ,  A61K36/8988 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.

公开(公告)号：US20170218369A1

公开(公告)日：2017-08-03

申请号：US15500354

申请日：2015-07-31

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Pan-Chyr Yang ,  Yi-Chung Chang ,  Wei-Yun Lai

IPC: C12N15/115 ,  C12N15/117 ,  A61K31/713

CPC classification number: C12N15/115 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/60 ,  A61P35/00 ,  C12N15/1138 ,  C12N15/117 ,  C12N2310/16 ,  C12N2310/17 ,  C12N2310/351

Abstract: Aptamers that bind to and antagonize PD-1 and uses thereof in promoting T cell proliferation, treating cancer or infectious diseases such as HIV infection.

公开(公告)号：US09562268B2

公开(公告)日：2017-02-07

申请号：US13966996

申请日：2013-08-14

Applicant: Academia Sinica

Inventor： Yuan-Tsong Chen ,  Shuen-lu Hung ,  Wen-hung Chung ,  Jer-Yuarn Wu

IPC: C12Q1/68 ,  C12P19/34 ,  G01N33/94 ,  C12M1/34

CPC classification number: C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/94

Abstract: The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most significant for carbamazepine-induced SJS/TEN, wherein all the patients tested have the HLA-B* 1502 allele. In addition, another HLA-B allele, HLA-B*5801, is particularly associated with SJS/TEN induced by allopurinol. Milder cutaneous reactions, such as maculopapular rash, erythema multiforme (EM), urticaria, and fixed drug eruption, are particularly associated with a third allele, HLA-B *4601. For any of the alleles, genetic markers (e.g., HLA markers, microsatellite, or single nucleotide polymorphism markers) located between DRB1 and HLA-A region of the specific HLA-B haplotype can also be used for the test.

Abstract translation: 本发明提供了一种预测患者发展不良药物反应（特别是SJS或TEN）的风险的方法。 发现HLA-B等位基因HLA-B * 1502与由各种药物诱导的SJS / TEN相关。 与HLA-B * 1502的相关性对于卡马西平诱导的SJS / TEN是最显着的，其中所有测试的患者具有HLA-B * 1502等位基因。 另外HLA-B等位基因HLA-B * 5801与别嘌呤醇诱导的SJS / TEN特别相关。 特别是与第三等位基因HLA-B * 4601相关的皮肤反应较轻，如斑丘疹，多形性红斑，荨麻疹和固定药物爆发。 对于任何等位基因，位于特异性HLA-B单倍型的DRB1和HLA-A区之间的遗传标记（例如HLA标记，微卫星或单核苷酸多态性标记）也可用于测试。

公开(公告)号：US20160346348A1

公开(公告)日：2016-12-01

申请号：US14723914

申请日：2015-05-28

Applicant: Academia Sinica ,  National Sun Yat-sen University

Inventor： Zhi-Hong Wen ,  Jyh-Yih Chen

IPC: A61K38/17

CPC classification number: A61K38/1706

Abstract: The present invention relates to a method for alleviating pain in a subject in need thereof, which comprises administering an effective amount of piscidin (PCD) peptide and a pharmaceutically acceptable carrier to the subject.

Abstract translation: 本发明涉及一种减轻有需要的受试者疼痛的方法，其包括将有效量的皮屑（PCD）肽和药学上可接受的载体给予受试者。

公开(公告)号：US09484193B2

公开(公告)日：2016-11-01

申请号：US14298911

申请日：2014-06-07

Applicant: Academia Sinica

Inventor： Chung-Hsuan Chen ,  Chein-Hung Chen ,  Hsin Yu Hsieh ,  Pang-Hung Hsu ,  Jung-Lee Lin

IPC: H01J49/00 ,  G01N33/68

CPC classification number: H01J49/0031 ,  G01N33/6818 ,  G01N33/6851 ,  H01J49/0054

Abstract: Apparatus and methods for automatic amino acid sequencing of a glycopeptide by mass spectrometry. The glycopeptide is fragmented by higher energy collision dissociation fragmentation, and sequentially fragmented by collision induced dissociation fragmentation. The glycopeptide Y1 ion is isolated, and the mass spectra of fragmented glycopeptide Y1 ions provide mass spectral peaks corresponding to the amino acid sequence of the glycopeptide.

Abstract translation: 通过质谱法对糖肽进行自动氨基酸测序的装置和方法。 糖肽通过较高的能量碰撞解离断裂而碎裂，并通过碰撞诱导的解离片段依次碎裂。 分离糖肽Y1离子，碎片糖肽Y1离子的质谱提供对应于糖肽的氨基酸序列的质谱峰。