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公开(公告)号：US10998175B2
公开(公告)日：2021-05-04
申请号：US16686203
申请日：2019-11-17
申请人： Academia Sinica
发明人： Abdil Ozdemir , Jung-Lee Lin , Chung-Hsuan Chen
摘要： Disclosed herein is a device for characterizing a biological sample or an airborne sample. According to embodiments of the present disclosure, the device comprises an electrospray source, a mass analyzer, a charge detector, and optionally, an ion guide. The present device is useful in analyzing the particle population in the biological or airborne sample based on the mass to charge (m/z) ratio and the charge (z) of each particle. Also disclosed herein are the methods of making a diagnosis of cancer by use of the present device, and methods of determining the mass distribution of particles in an airborne sample.
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2.发明授权公开(公告)号：US09006650B2
公开(公告)日：2015-04-14
申请号：US14274707
申请日：2014-05-10
申请人： Academia Sinica
发明人： Chung-Hsuan Chen , Jung-Lee Lin , Huan Chang Lin
IPC分类号： H01J49/26 , H01J49/42 , H01J49/36 , G01N27/66 , G01N33/483
CPC分类号： H01J49/36 , G01N33/4833 , H01J49/164 , H01J49/4225 , H01J49/424
摘要： Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 105 to 1010, an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages.
摘要翻译： 用于进行纳米颗粒或病毒分析物的质谱分析的装置和方法。 设备可以包括激光解吸板，质量分析器，被配置为测量从105到1010的m / z范围内的质量，围绕质量分析器的电屏蔽，以及电荷敏感检测器，其中激光点火与 应用的射频电压。
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公开(公告)号：US11119078B2
公开(公告)日：2021-09-14
申请号：US16412704
申请日：2019-05-15
申请人： ACADEMIA SINICA
发明人： Chung-Hsuan Chen , Chen-Yu Hsieh , Jung-Lee Lin
摘要： Apparatus and methods for high performance liquid chromatography. The apparatus includes a preparation loop comprising two linear stepping pumps, a sample loop comprising a sample injector, a chromatography column, and a detector device. The detector device can include a flash lamp, a flow cell, and a light sensor comprising an entrance slit, a grating; and a charge-coupled device array.
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公开(公告)号：US10317379B2
公开(公告)日：2019-06-11
申请号：US14551050
申请日：2014-11-23
申请人： Academia Sinica
发明人： Chung-Hsuan Chen , Chen-Yu Hsieh , Jung-Lee Lin
摘要： Apparatus and methods for high performance liquid chromatography. The apparatus includes a preparation loop comprising two linear stepping pumps, a sample loop comprising a sample injector, a chromatography column, and a detector device. The detector device can include a flash lamp, a flow cell, and a light sensor comprising an entrance slit, a grating; and a charge-coupled device array.
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公开(公告)号：US08637814B2
公开(公告)日：2014-01-28
申请号：US13691785
申请日：2012-12-01
申请人： Academia Sinica
发明人： Chung-Hsuan Chen , Jung-Lee Lin , Nien-Yeen Hsu , Yi-Sheng Wang
CPC分类号： H05H5/047 , H01J49/06 , H01J49/40 , H01J49/403
摘要： A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.
摘要翻译： 提供了一种用于加速分析物的新系统和方法，包括但不限于分子离子，生物分子，聚合物，纳米和微粒。 本发明可用于在诸如质谱法，进行碰撞诱导的解离分子结构分析和使用加速分析物的探测表面和样品等应用中提高检测灵敏度。
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公开(公告)号：US09524859B2
公开(公告)日：2016-12-20
申请号：US14450267
申请日：2014-08-03
申请人： Academia Sinica
发明人： Jung-Lee Lin , Chung-Hsuan Chen , Chen-Yu Hsieh
CPC分类号： H01J49/165 , H01J49/0495
摘要： Apparatus and methods for creating a pulsed ion beam. The pulsed ion beam can be used for performing mass spectrometry. A pulsed solenoid valve can provide a pulsed ion beam from an electrospray in a pre-vacuum chamber. The pulsed ion beam can enter a high vacuum region and a mass analyzer for mass spectrometry.
摘要翻译： 用于产生脉冲离子束的装置和方法。 脉冲离子束可用于进行质谱分析。 脉冲电磁阀可以在预真空室中提供来自电喷雾的脉冲离子束。 脉冲离子束可以进入高真空区域，质谱仪可以进行质谱分析。
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公开(公告)号：US09484193B2
公开(公告)日：2016-11-01
申请号：US14298911
申请日：2014-06-07
申请人： Academia Sinica
CPC分类号： H01J49/0031 , G01N33/6818 , G01N33/6851 , H01J49/0054
摘要： Apparatus and methods for automatic amino acid sequencing of a glycopeptide by mass spectrometry. The glycopeptide is fragmented by higher energy collision dissociation fragmentation, and sequentially fragmented by collision induced dissociation fragmentation. The glycopeptide Y1 ion is isolated, and the mass spectra of fragmented glycopeptide Y1 ions provide mass spectral peaks corresponding to the amino acid sequence of the glycopeptide.
摘要翻译： 通过质谱法对糖肽进行自动氨基酸测序的装置和方法。 糖肽通过较高的能量碰撞解离断裂而碎裂，并通过碰撞诱导的解离片段依次碎裂。 分离糖肽Y1离子，碎片糖肽Y1离子的质谱提供对应于糖肽的氨基酸序列的质谱峰。
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公开(公告)号：US20150143880A1
公开(公告)日：2015-05-28
申请号：US14551050
申请日：2014-11-23
申请人： Academia Sinica
发明人： Chung-Hsuan Chen , Chen-Yu Hsieh , Jung-Lee Lin
IPC分类号： G01N30/74
摘要： Apparatus and methods for high performance liquid chromatography. The apparatus includes a preparation loop comprising two linear stepping pumps, a sample loop comprising a sample injector, a chromatography column, and a detector device. The detector device can include a flash lamp, a flow cell, and a light sensor comprising an entrance slit, a grating; and a charge-coupled device array.
摘要翻译： 高效液相色谱仪的设备和方法。 该装置包括一个包括两个线性步进泵的制备回路，一个样品回路，包括一个样品注射器，一个色谱柱和一个检测器装置。 检测器装置可以包括闪光灯，流动池和包括入口狭缝，光栅的光传感器; 和电荷耦合器件阵列。
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公开(公告)号：US20150136973A1
公开(公告)日：2015-05-21
申请号：US14450267
申请日：2014-08-03
申请人： Academia Sinica
发明人： Jung-Lee Lin , Chung-Hsuan Chen , Chen-Yu Hsieh
CPC分类号： H01J49/165 , H01J49/0495
摘要： Apparatus and methods for creating a pulsed ion beam. The pulsed ion beam can be used for performing mass spectrometry. A pulsed solenoid valve can provide a pulsed ion beam from an electrospray in a pre-vacuum chamber. The pulsed ion beam can enter a high vacuum region and a mass analyzer for mass spectrometry.
摘要翻译： 用于产生脉冲离子束的装置和方法。 脉冲离子束可用于进行质谱分析。 脉冲电磁阀可以在预真空室中提供来自电喷雾的脉冲离子束。 脉冲离子束可以进入高真空区域，质谱仪可以进行质谱分析。
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10.发明申请公开(公告)号：US20140346344A1
公开(公告)日：2014-11-27
申请号：US14274707
申请日：2014-05-10
申请人： Academia Sinica
发明人： Chung-Hsuan Chen , Jung-Lee Lin , Huan Chang Lin
IPC分类号： G01N27/66 , H01J49/42 , G01N33/483 , H01J49/36
CPC分类号： H01J49/36 , G01N33/4833 , H01J49/164 , H01J49/4225 , H01J49/424
摘要： Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 105 to 1010, an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages.
摘要翻译： 用于进行纳米颗粒或病毒分析物的质谱分析的装置和方法。 设备可以包括激光解吸板，质量分析器，被配置为测量从105到1010的m / z范围内的质量，围绕质量分析器的电屏蔽，以及电荷敏感检测器，其中激光点火与 应用的射频电压。
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