公开(公告)号：US08144833B2

公开(公告)日：2012-03-27

申请号：US12763530

申请日：2010-04-20

申请人： Sebastiaan Breedveld

发明人： Sebastiaan Breedveld

IPC分类号： A61N5/10

CPC分类号： A61N5/1038

摘要： The present invention provides a method for updating and optimizing a treatment plan for radiotherapy. An initial treatment plan, calculated using a constraint-driven method, may be updated using a weighted-sum method, where Lagrange multipliers generated in the constraint method are reused as the weights for the weighted sum. This method results in acceptable updated treatment plans that are generated in a small fraction of the time taken to generate an entirely new treatment plan, reducing patient discomfort and ensuring the radiotherapy facility can treat more patients.

摘要翻译： 本发明提供了一种更新和优化放射治疗计划的方法。 使用约束驱动方法计算的初始治疗计划可以使用加权和方法来更新，其中在约束方法中生成的拉格朗日乘数被重新用作加权和的权重。 这种方法产生可接受的更新的治疗计划，这些计划在产生全新治疗计划所花费的时间的一小部分中产生，减少患者不适，并确保放射治疗设施可以治疗更多的患者。

公开(公告)号：US20110319741A1

公开(公告)日：2011-12-29

申请号：US12821660

申请日：2010-06-23

申请人： Kevin Brown

发明人： Kevin Brown

IPC分类号： A61B5/05

CPC分类号： G06F19/3481 ,  A61N5/1037

摘要： Embodiments of the present invention provide a method of pre-approving a range of hypothetical spatial variations of the target whilst an initial treatment plan is generated. This allows the treatment plan to be later adapted to account for spatial variations of the target region falling within those pre-approved ranges, without going through time-consuming steps of quality assurance on the adapted plan.

摘要翻译： 本发明的实施例提供了一种在产生初始治疗计划时预先批准目标的假设空间变化范围的方法。 这使得治疗计划稍后适应于考虑到落在那些预先批准的范围内的目标区域的空间变化，而不需要经过适应计划的质量保证的耗时步骤。

公开(公告)号：US20110255665A1

公开(公告)日：2011-10-20

申请号：US12763530

申请日：2010-04-20

申请人： Sebastiaan Breedveld

发明人： Sebastiaan Breedveld

IPC分类号： A61N5/10

CPC分类号： A61N5/1038

摘要： The present invention provides a method for updating and optimizing a treatment plan for radiotherapy. An initial treatment plan, calculated using a constraint-driven method, may be updated using a weighted-sum method, where Lagrange multipliers generated in the constraint method are reused as the weights for the weighted sum. This method results in acceptable updated treatment plans that are generated in a small fraction of the time taken to generate an entirely new treatment plan, reducing patient discomfort and ensuring the radiotherapy facility can treat more patients.

摘要翻译： 本发明提供了一种更新和优化放射治疗计划的方法。 使用约束驱动方法计算的初始处理计划可以使用加权和方法来更新，其中在约束方法中生成的拉格朗日乘数被重新用作加权和的权重。 这种方法产生可接受的更新的治疗计划，这些计划在产生全新治疗计划所花费的时间的一小部分中产生，减少患者不适，并确保放射治疗设施可以治疗更多的患者。

公开(公告)号：US20110243387A1

公开(公告)日：2011-10-06

申请号：US13132805

申请日：2008-12-08

申请人： Kevin Brown

发明人： Kevin Brown

IPC分类号： G06K9/00

CPC分类号： A61B6/032 ,  A61B5/113

摘要： The present invention therefore provides a method for the analysis of radiographic images, comprising the steps of acquiring a plurality of projection images of a patient, acquiring a surrogate signal indicative of the location of a target structure in the patient, reconstructing a plurality of volumetric images of the patient from the projection images, each volumetric image being reconstructed from projection images having a like breathing phase, identifying the position of the target structure such as a tumour in each volumetric image, associating a surrogate signal with each of the projection images, and determining a relationship between the surrogate signal and the position of the target structure. Multiple projection images having a like breathing phase can be grouped for reconstruction, to provide sufficient numbers for reconstruction. The analysis of the multiple values of the surrogate associated with each breathing phase can be used to determine the mean surrogate value and its variation. Multiple values of the surrogate signal associated with the same nominal breathing phase can be used to determine a mean value of the surrogate signal for the target position associated with that phase and a variation of the value of the surrogate signal for the target position associated with that phase. The breathing phase of specific projection images can be obtained by analysis of one or more features in the images, such as the method we described in U.S. Pat. No. (7,356,112), or otherwise.

摘要翻译： 因此，本发明提供了一种用于分析放射线图像的方法，包括以下步骤：获取患者的多个投影图像，获取指示患者中目标结构的位置的替代信号，重建多个体积图像 从投影图像的患者的每个体积图像中，从具有相似呼吸相位的投影图像重建每个体积图像，识别每个体积图像中的诸如肿瘤的目标结构的位置，将替代信号与每个投影图像相关联，以及 确定替代信号与目标结构的位置之间的关系。 具有类似呼吸相位的多个投影图像可以被分组以进行重建，以提供足够数量的重建。 可以使用与每个呼吸阶段相关联的代理的多个值的分析来确定平均替代值及其变化。 可以使用与相同标称呼吸相位相关联的替代信号的多个值来确定与该相位相关联的目标位置的替代信号的平均值，以及与该相位相关联的目标位置的替代信号的值的变化 相。 特定投影图像的呼吸阶段可以通过分析图像中的一个或多个特征来获得，例如我们在美国专利中描述的方法。 （7,356,112），否则。

公开(公告)号：US20110201918A1

公开(公告)日：2011-08-18

申请号：US12704944

申请日：2010-02-12

申请人： Duncan Neil Bourne

发明人： Duncan Neil Bourne

IPC分类号： A61B5/055 ,  A61N5/00 ,  G21K1/04

CPC分类号： A61N5/1049 ,  A61N2005/1055

摘要： A radiotherapy system comprises a patient support, moveable along a translation axis, an imaging apparatus, comprising a first magnetic coil and a second magnetic coil, the first and second magnetic coils having a common central axis parallel to the translation axis, and being displaced from one another along the central axis to form a gap therebetween, the imaging apparatus being configured to obtain an image of a patient on the patient support and a source of radiation mounted on a chassis, the chassis being rotatable about the central axis and the source being adapted to emit a beam of radiation through the gap along a beam axis that intersects with the central axis, the beam having a first extent in a first direction parallel to the central axis, and a second, greater extent in a second direction transverse to the central axis.

摘要翻译： 放射治疗系统包括可沿着平移轴线移动的患者支架，包括第一电磁线圈和第二电磁线圈的成像装置，所述第一和第二磁线圈具有平行于所述平移轴的公共中心轴线， 另一个沿着中心轴线在其间形成间隙，成像装置被配置为获得病人支撑物上的患者的图像和安装在底盘上的辐射源，底架可围绕中心轴线旋转，而源 适于沿着与所述中心轴线相交的光束轴线沿着所述间隙发射辐射束，所述光束在平行于所述中心轴线的第一方向上具有第一范围，并且在垂直于所述中心轴线的第二方向上具有第二较大程度 中心轴。

公开(公告)号：US20110142202A1

公开(公告)日：2011-06-16

申请号：US12992727

申请日：2009-05-15

申请人： Kevin Brown ,  Maria Giulia Thompson ,  Vibeke Nordmark Hansen ,  Philip Mark Evans ,  David Anthony Roberts

发明人： Kevin Brown ,  Maria Giulia Thompson ,  Vibeke Nordmark Hansen ,  Philip Mark Evans ,  David Anthony Roberts

IPC分类号： A61N5/10 ,  H01J35/08

CPC分类号： A61N5/1049 ,  A61B6/06 ,  A61B6/4042 ,  A61B6/583 ,  A61N2005/1061 ,  G21K1/02 ,  G21K1/10 ,  H01J35/08 ,  H01J2235/081 ,  H01J2235/087

摘要： It is desirable to achieve a co-incident investigative kV source for a therapeutic MV source—a so-called “beams-eye-view” source. It has been suggested that bremsstrahlung radiation from an electron window be employed; we propose a practical structure for achieving this which can switch easily between a therapeutic beam and a beam-eye-view diagnostic beam capable of offering good image resolution. Such a radiation source comprises an electron gun, a pair of targets locatable in the path of a beam produced by the electron gun, one target of the pair being of a material with a lower atomic number than the other, and an electron absorber insertable into and withdrawable from the path of the beam. In a preferred form, the electron gun is within a vacuum chamber, and the pair of targets are located at a boundary of the vacuum chamber. The lower atomic number target can be Nickel and the higher atomic number target Copper and/or Tungsten. The electron absorber can be Carbon, and can be located within the primary collimator, or within one of a plurality of primary collimators interchangeably locatable in the path of the beam. Such a radiation source can be included within a radiotherapy apparatus, to which the present invention further relates. A flat panel imaging device for this source can be optimised for low energy x-rays rather than high energy; Caesium Iodide-based panels are therefore suitable.

摘要翻译： 期望实现用于治疗性MV源的共同调查性kV源 - 所谓的“眼 - 视”源。 有人建议使用来自电子窗的bre致辐射; 我们提出了实现这一点的实际结构，其可以在能够提供良好的图像分辨率的治疗光束和眼睛视图诊断光束之间容易地切换。 这样的辐射源包括电子枪，一对可定位在由电子枪产生的光束的路径中的一对靶，该对中的一个靶是具有比另一个更低原子序数的材料，以及电子吸收体可插入 并从梁的路径中抽出。 在优选形式中，电子枪位于真空室内，并且该对靶位于真空室的边界处。 较低的原子序号目标可以是镍，较高原子序号的目标铜和/或钨。 电子吸收器可以是碳，并且可以位于主准直器内，或者位于可互换定位在光束路径中的多个主准直仪之一内。 这样的辐射源可以包括在本发明进一步涉及的放射治疗装置内。 用于该源的平板成像装置可以针对低能x射线而不是高能量进行优化; 因此，基于碘化铯的面板是合适的。

公开(公告)号：US20110121763A1

公开(公告)日：2011-05-26

申请号：US13054732

申请日：2008-07-18

申请人： Philip Sadler ,  David Harrison ,  Neil Mccann

发明人： Philip Sadler ,  David Harrison ,  Neil Mccann

IPC分类号： H05H9/00

CPC分类号： H05H9/00

摘要： We propose that during the factory testing of the linac, rather than simply confirming that the beam falls within the permissible ranges set out in the standard, the beam is in fact adjusted towards a standard signature. A new (or existing) linac could then be paired to a new linac, or to an existing linac, such as one that it is to operate alongside or one that it is to replace. Treatment plans would then be transferable between such pairs of linacs. In addition, the standard signature to which the linacs were approximated could be placed towards the centre of the permitted ranges, to produce linacs that were more reliable over the very long term. This requires a linac that has automatically adjustable parameters, so that a suitable programmed computer is able to monitor the output of the linac and adjust its operating parameters. We therefore provide a radiation source comprising a linear accelerator, beam control circuitry for the linear accelerator, an electronic control apparatus for the control circuitry arranged to adjust properties thereof, and a monitor for detecting properties of the radiation beam produced by the linear accelerator, wherein the control apparatus is adapted to retain a set of beam properties and periodically activate the accelerator, measure the current beam properties via the monitor, compare the measured beam properties to the retained beam properties, and potentially adjust the control circuitry properties to align the beam properties towards the retained beam properties. The beam properties that are measured may include at least one of beam flatness and beam width. The retained beam properties can be the properties of the beam produced by the linear accelerator when new, or the properties of a standard beam. The control apparatus is preferably arranged to send a message if the difference between the measured beam properties and the retained beam properties exceeds a threshold. It may also send a message to a remote location if the difference between the measured beam properties and the retained beam properties exceeds a second threshold.

公开(公告)号：US07860215B2

公开(公告)日：2010-12-28

申请号：US12441005

申请日：2006-09-13

申请人： Andrew Long ,  Kevin Brown ,  John Allen

发明人： Andrew Long ,  Kevin Brown ,  John Allen

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/032 ,  A61B6/4488 ,  A61N2005/1054

摘要： Flat panel images obtained during concurrent radiotherapy typically suffer from artefacts that relate to the pulses of MV energy. For a radiotherapeutic apparatus comprising a pulsed source of therapeutic radiation, a detector comprising control circuitry, an array of pixel elements, each having a signal output and an ‘enable’ input and being arranged to release a signal via the signal output upon being triggered by the enable input, and an interpreter arranged to receive the signal outputs of the pixel elements, the interpreter having a reset control, there are advantages in the control circuitry being adapted to reset the interpreter after a pulse of therapeutic radiation, prior to enabling at least one pixel of the array. Alternatively, the control circuitry can prompt a plurality of pulses by the pulsed source and then enable a plurality of pixels of the array. In effect, the therapeutic pulses are grouped into a short flurry of pulses. It is therefore preferred that the plurality of pixels comprises substantially all the pixels of the array.

摘要翻译： 在同时放射治疗期间获得的平板图像通常遭受与MV能量的脉冲有关的伪像。 对于包括脉冲的治疗辐射源的放射治疗装置，包括控制电路的检测器，每个具有信号输出和“使能”输入的像素元件阵列，并且被布置成在由...被触发时通过信号输出释放信号 所述使能输入和解释器被布置为接收所述像素元件的信号输出，所述解释器具有复位控制，所述控制电路中的优点是适于在治疗辐射脉冲之后复位解释器， 数组的一个像素。 或者，控制电路可以通过脉冲源提示多个脉冲，然后启用阵列的多个像素。 实际上，治疗脉冲被分组成短脉冲。 因此，优选地，多个像素包括阵列的基本上所有的像素。

公开(公告)号：US20100252754A1

公开(公告)日：2010-10-07

申请号：US12740291

申请日：2007-10-30

申请人： Kevin Brown ,  Ralph Streamer ,  Duncan Bourne

发明人： Kevin Brown ,  Ralph Streamer ,  Duncan Bourne

IPC分类号： A61N5/10 ,  G21K1/02

CPC分类号： A61N5/1049 ,  A61N5/1042 ,  A61N5/1067 ,  A61N2005/1061

摘要： Realtime beam shape adjustment in response to (for example) online CT scanning of a patient during treatment is assisted by the radiotherapy apparatus comprising a source adapted to emit a beam of therapeutic radiation, a collimator for delimiting the radiation beam, the collimator comprising a plurality of leaves arranged alongside each other and be moveable longitudinally so that the tips of the leaves define a variable edge of the collimator, the leaves being mounted on a support that is moveable laterally with respect to the leaves. In this way, movements of the tumour that are perpendicular to the direction of leaf motion can be accommodated by simply moving the collimator bodily so as to accommodate this. It is preferred that the apparatus also includes a control means adapted to receive information as to the location of the target volume, and, on the basis of that information, control the longitudinal positions of the leaves and the lateral position of the support. It is also preferred that the support tilts as it moves laterally along a path. This can be achieved, by example, by bearings that are moveable on suitable guides, or by mounting the support on a plurality of pivot arms of unequal lengths. The lengths of such pivot arms can be adjusted as necessary.

摘要翻译： 响应于（例如）治疗期间患者的在线CT扫描的实时波束形状调整由包括适于发射治疗辐射束的源的放射治疗装置辅助，用于限定辐射束的准直器，准直器包括多个 的叶片彼此并排设置并且可纵向移动，使得叶片的尖端限定准直器的可变边缘，叶片安装在相对于叶片横向移动的支撑件上。 以这种方式，垂直于叶片运动方向的肿瘤的运动可以通过简单地移动准直器以适应这一点来适应。 优选地，该装置还包括适于接收关于目标体积的位置的信息的控制装置，并且基于该信息控制叶片的纵向位置和支撑件的横向位置。 还优选的是，当支撑件沿着路径横向移动时，支撑件倾斜。 这可以通过例如通过在合适的导轨上可移动的轴承，或者通过将支撑件安装在不等长度的多个枢轴臂上来实现。 这种枢转臂的长度可以根据需要进行调节。

公开(公告)号：US20090293883A1

公开(公告)日：2009-12-03

申请号：US11919058

申请日：2006-04-26

申请人： Thomas Arn

发明人： Thomas Arn

IPC分类号： A61B17/00

CPC分类号： A61B90/14 ,  A61B90/50 ,  A61B2017/00477

摘要： A device is provided for connecting of a ring-shaped frame, which is adapted for fixation to the head of a patient during neurological diagnosis, therapy or surgery, to a supplementary equipment, for positioning of the frame and the equipment in a predetermined relation to each other. The frame comprises a connecting hole and the equipment comprises a connecting pin for insertion into the hole in the frame during positioning. The hole opens into a surface of the frame and has an enlarged portion, which preferably is diverging towards the surface of the frame, closest to the surface and a cylindrical portion beyond the diverging portion, whereas the connecting pin has a cross sectional dimension which is equal to or slightly smaller than the cross sectional dimension of the cylindrical portion in the hole.

摘要翻译： 提供一种装置，用于将环形框架连接到辅助设备，该环形框架适于在神经系统诊断，治疗或手术期间固定到患者的头部，用于将框架和设备以预定的关系定位 彼此。 该框架包括连接孔，并且该设备包括用于在定位期间插入框架中的孔中的连接销。 该孔通向框架的表面，并且具有一扩大部分，该部分最好朝着最靠近表面的框架表面发散，而一个圆柱形部分超出了发散部分，而连接销的截面尺寸为 等于或略小于孔中圆柱形部分的横截面尺寸。