公开(公告)号：US11161369B2

公开(公告)日：2021-11-02

申请号：US15370744

申请日：2016-12-06

申请人： Sistine Solar, Inc.

发明人： Anthony John Occidentale ,  Senthil Balasubramanian ,  Jody Fu ,  Jonathan Mailoa ,  Ido Salama ,  Samantha Holmes

IPC分类号： B44F1/06 ,  H01L31/049 ,  B44F1/08 ,  H01L31/048 ,  H01L31/02 ,  H01L31/055 ,  H02S20/23 ,  H01L31/0216

摘要： In some aspects, graphic layers for depicting a visible representation of an image along a surface of a photovoltaic module can include a plurality of substantially opaque isolated regions; and at least one substantially transparent contiguous region surrounding the substantially opaque isolated regions, wherein an outer surface of the at least one substantially transparent contiguous region comprises a matte surface finish.

公开(公告)号：US11141479B2

公开(公告)日：2021-10-12

申请号：US16551326

申请日：2019-08-26

申请人： Kiniksa Pharmaceuticals, Ltd.

发明人： Mark Cornell Manning ,  Zahra Shahrokh ,  Dave Nichols ,  Philip M Levesque ,  Ryan Erik Holcomb

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07K16/24 ,  A61K39/00

摘要： The present invention provides, among other things, stable formulations comprising an anti-oncostatin M receptor (OSMR) antibody and having a pH ranging from approximately 6.0-7.6, wherein less than approximately 5% of the anti-OSMR antibody exists as high molecular weight (HMW) species in the formulation.

公开(公告)号：US11086949B1

公开(公告)日：2021-08-10

申请号：US17185425

申请日：2021-02-25

申请人： FMR LLC

发明人： Abhishek Desai ,  Bibhash Chakrabarty ,  Sateesh Panda

IPC分类号： G06F16/9532 ,  H04L29/08 ,  G06F16/9535 ,  G06F16/954 ,  G06F40/30

摘要： Systems and methods for generating proposed search queries based on sequence semantics. The method includes receiving clickstream data from a database. The method also includes generating for each user a digital timeline based on the clickstream data. The method further includes determining for each user event pairs based on the digital timeline. The method also includes generating a vector matrix including the event pairs for each user. The method further includes receiving an initial search query from a user. The method also includes determining an intended user activity based on the initial search query. The method further includes generating proposed search queries based on the vector matrix, the intended user activity, and the initial search query.

公开(公告)号：US11065237B2

公开(公告)日：2021-07-20

申请号：US16786187

申请日：2020-02-10

申请人： Akebia Therapeutics, Inc.

发明人： James Densmore Copp ,  Ann W. Newman ,  Anne Luong

IPC分类号： C07D213/65 ,  A61K31/4418 ,  A61K31/444 ,  A61K9/20 ,  A61K9/48 ,  C07D213/81 ,  A61K9/14 ,  C07D213/803 ,  C07D221/00

摘要： Provided herein are solid forms comprising {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders.

公开(公告)号：US11059841B2

公开(公告)日：2021-07-13

申请号：US16196664

申请日：2018-11-20

申请人： Translate Bio, Inc.

发明人： Frank DeRosa ,  Anusha Dias ,  Shrirang Karve ,  Michael Heartlein

IPC分类号： C12Q1/68 ,  C07H21/00 ,  C07H1/06 ,  C12N15/10 ,  C07H21/02

摘要： The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of (a) precipitating mRNA from an impure preparation; (b) subjecting the impure preparation comprising precipitated mRNA to a purification process involving membrane filtration such that the precipitated mRNA is captured by a membrane; and (c) eluting the captured precipitated mRNA from the membrane by re-solubilizing the mRNA, thereby resulting in a purified mRNA solution. In some embodiments, a purification process involving membrane filtration suitable for the present invention is tangential flow filtration.

公开(公告)号：US11049150B2

公开(公告)日：2021-06-29

申请号：US16016412

申请日：2018-06-22

申请人： Criteo SA

发明人： Clément Calauzènes ,  Christophe Renaudin ,  Alexandre Gilotte ,  Eustache Diemert

IPC分类号： G06Q30/00 ,  G06Q30/02 ,  G06F7/58

摘要： Methods and systems are described herein for incremental bidding for electronic advertisements. A computing device generates, for a user during a first time period, first randomized bids for available impression opportunities, the first randomized bids based upon an estimated value and a first random factor and using a context of bid requests. The computing device transmits the first randomized bids to a remote device. The computing device determines whether interaction events associated with impression opportunities occurred. The computing device estimates second randomized bids based upon an estimated value and a second random factor and using the context. The computing device estimates a relative incrementality of a bidding policy based upon the second randomized bids over a bidding policy based upon the first randomized bids, and optimizes the bidding policy based upon second randomized bids. The computing device changes a production bidding policy based upon the optimized policy.

公开(公告)号：US11019715B2

公开(公告)日：2021-05-25

申请号：US16035551

申请日：2018-07-13

申请人： MKS Instruments, Inc.

发明人： Xing Chen ,  Ilya Pokidov ,  Atul Gupta

IPC分类号： B23K10/00 ,  H05H1/46 ,  H05H1/24 ,  H01J37/32

摘要： A plasma chamber of a plasma processing system is provided. The plasma chamber defines a plasma channel having a first side and a second side oppositely disposed along a length of the plasma channel. The plasma chamber comprises a first section and a second section constructed from a dielectric material and an interface that bonds together the first and second sections at between a first flange of the first section and a third flange of the second section and between a second flange of the first section and a fourth flange of the second section.

公开(公告)号：US11013812B2

公开(公告)日：2021-05-25

申请号：US16599928

申请日：2019-10-11

申请人： Translate Bio, Inc.

发明人： Frank DeRosa ,  Michael Heartlein ,  Shrirang Karve

IPC分类号： A61K47/54 ,  A61K9/00 ,  A61K48/00 ,  A61K47/69 ,  A61K47/60 ,  A61K38/17 ,  A61P11/12 ,  A61K9/127 ,  A61K47/28

摘要： The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid. In some embodiments, the present invention provides compositions and methods in which the lipid nanoparticles further comprise helper lipids and PEG-modified lipids. The resulting formulation comprises a high encapsulation percentage for nucleic acids.

公开(公告)号：US11010015B2

公开(公告)日：2021-05-18

申请号：US16534452

申请日：2019-08-07

申请人： FMR LLC

发明人： Peter McCormack ,  Michael Khan ,  Brian Lough

IPC分类号： G06F3/0481 ,  G06F3/0346 ,  G06F3/01 ,  G06F3/0484 ,  G06T19/20

摘要： A system is provided for visualizing data in a computerized visual environment. The system comprises (i) a viewing device that displays, to a user of the viewing device, a graphical user interface within a virtual three-dimensional space, (ii) a handheld device configured to allow the user to customize the display of a three-dimensional data visualization within the graphical user interface using hand motions made by the user, and (iii) a computing device coupled to the viewing device and the handheld device. The computing device is configured to cause to display to the user on the viewing device a filter plane overlaying the three-dimensional data visualization, detect a position of the filter plane that is movable by the user in the graphical user interface, and alter the three-dimensional visualization in the graphical user interface based on the detected position of the filter plane.

公开(公告)号：US10965812B1

公开(公告)日：2021-03-30

申请号：US17109046

申请日：2020-12-01

申请人： FMR LLC

发明人： Aniruddha Das ,  Saurav Pattnaik

IPC分类号： H04M3/00 ,  H04M5/00 ,  H04M3/51 ,  G10L15/26 ,  G06F40/56 ,  G06F40/35

摘要： Methods and apparatuses are described for generating a recommended conversation topic flow. A server executes a topic modelling algorithm on voice call transcripts to determine a distribution of topics present in the transcripts. The server generates a historical topic flow for each transcript by determining topic-related words in text blocks in the transcript and assigning a score to each text block. The server categorizes each topic flow as positive or negative based upon outcomes associated with the transcript. The server trains a classification model using the categorized topic flows as input. The server captures a bitstream corresponding to a current voice call and converts the bitstream into unstructured text. The server executes the classification model on the unstructured text to determine whether a call topic flow is positive or negative. The server generates topic recommendations and transmits the recommendations to a second client device.