公开(公告)号：US20150056306A1

公开(公告)日：2015-02-26

申请号：US14364992

申请日：2012-12-13

Applicant: AMORPHICAL LTD

Inventor： Amir Sagi ,  Assaf Shechter ,  Galit Shaltiel-Gold ,  Michal Daniely ,  Oren Meiron

IPC: A61K33/10 ,  A61K31/663

CPC classification number: A61K33/10 ,  A61K31/663 ,  A61K35/612

Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.

Abstract translation: 提供了用于治疗钙吸收不良的方法和与钙吸收不良相关的病症，使用含有稳定的无定形碳酸钙的组合物。 进一步提供的是使用与骨吸收抑制剂组合施用所述组合物来增加骨代谢相关障碍，疾病或病症中的骨矿物质密度的方法。

公开(公告)号：US12121538B2

公开(公告)日：2024-10-22

申请号：US17319292

申请日：2021-05-13

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K47/24 ,  A61P31/00 ,  A61P35/00

CPC classification number: A61K33/10 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0073 ,  A61K9/10 ,  A61K9/143 ,  A61K47/24 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Kits for preparing suspension compositions of the present invention are provided as well.

公开(公告)号：US20240018009A1

公开(公告)日：2024-01-18

申请号：US18227077

申请日：2023-07-27

Applicant: AMORPHICAL LTD.

Inventor： Yossi BEN ,  Yigal BLUM ,  Roni Antoine ILLOS ,  Ben ASHKENAZI

IPC: C01F5/24 ,  C01F11/18 ,  C01G9/00 ,  A61K33/10 ,  A61K33/30 ,  A61K33/42 ,  A61K9/16 ,  A61K9/10

CPC classification number: C01F5/24 ,  C01F11/18 ,  C01G9/00 ,  A61K33/10 ,  A61K33/30 ,  A61K33/42 ,  C01P2002/02 ,  A61K9/10 ,  C01P2004/03 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/12 ,  A61K9/16

Abstract: The present invention provides a composition including a particle, the particle includes a carbonate species of a first divalent metal and carbonate specie of a second divalent metal; wherein the particle is amorphous; wherein the first divalent metal and the second divalent metal are in an oxidation state of +2; and wherein the first divalent metal and the second divalent metal is each independently selected from: Ca, Zn, Fe, Cu, Co, Ni, Mn, Mg and Cr. Further provided is a composition including a divalent metal carbonate including any derivative thereof, and at least one stabilizing agent, wherein the divalent metal is selected from: Zn, Cu, Co, Mn, Mg, and Ni, optionally being characterized by BET between 20 and 200 m2/g. Pharmaceutical or nutraceutical compositions including the composition of particles disclosed, are also provided.

公开(公告)号：US11446327B2

公开(公告)日：2022-09-20

申请号：US15329664

申请日：2015-07-30

Applicant: AMORPHICAL LTD.

Inventor： Ali Abo Riziq ,  Sharon Hershkovitz ,  Yosef Ben ,  Yigal Blum

IPC: A61K33/10 ,  C01F11/18 ,  A23C9/13 ,  A23C9/152 ,  A23C19/09 ,  A23C19/068 ,  A23C19/076 ,  A23L33/16 ,  A61K9/00 ,  A61K9/10 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/40 ,  A23C13/12 ,  A23C11/00

Abstract: The present invention provides stable amorphous calcium carbonate (ACC) compositions, and food articles comprising said compositions.

公开(公告)号：US20220152094A1

公开(公告)日：2022-05-19

申请号：US17456693

申请日：2021-11-29

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61P21/00 ,  A61P15/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US11052107B2

公开(公告)日：2021-07-06

申请号：US15579010

申请日：2016-06-02

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum ,  Hagay Moshe ,  Ben Ashkenazi

IPC: A61K9/10 ,  A61K9/14 ,  A61K33/10 ,  A61K47/24 ,  A61K9/00 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate ((′( (″) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.

公开(公告)号：US10758565B2

公开(公告)日：2020-09-01

申请号：US15578829

申请日：2016-06-02

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum

IPC: A61K31/00 ,  A61K33/10 ,  A61K9/00 ,  A61K9/14 ,  A61P35/00 ,  A61K47/24 ,  A61K9/10 ,  A61P31/00

Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Further provided are ACC compositions suitable for buccal or sublingual administration.

公开(公告)号：US20190262391A1

公开(公告)日：2019-08-29

申请号：US16343463

申请日：2017-10-23

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben

IPC: A61K33/10 ,  A61K31/66 ,  A61P35/02 ,  A61K9/00 ,  A23L29/00

Abstract: The present invention provides compositions and methods of treating a leukemia, including chronic lymphocytic leukemia, wherein the method comprises administering a stabilized amorphous calcium carbonate to a person in need thereof.

公开(公告)号：US20190030068A1

公开(公告)日：2019-01-31

申请号：US16069762

申请日：2017-01-17

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61P21/00 ,  A61K9/00 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071 ,  A61P15/08 ,  A61K47/24 ,  A61K47/02 ,  A61K47/26 ,  A61K47/12

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US10064890B2

公开(公告)日：2018-09-04

申请号：US14364992

申请日：2012-12-13

Applicant: AMORPHICAL LTD

Inventor： Amir Sagi ,  Assaf Shechter ,  Galit Shaltiel-Gold ,  Michal Daniely ,  Oren Meiron

IPC: A61K33/10 ,  A61K31/663 ,  A61K35/612

Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.