-
公开(公告)号:US11917123B2
公开(公告)日:2024-02-27
申请号:US17433058
申请日:2020-02-21
发明人: Brandon Hellman , Yuzuru Takashima
IPC分类号: G03B21/00 , H04N13/365 , H04N13/337 , H04N13/363
CPC分类号: H04N13/365 , H04N13/337 , H04N13/363
摘要: A light projection system for projecting full-resolution, high quality images into different directions. The system includes a light source configured to provide a homogenous output beam of light and an illumination shaping optic elements configured with at least one of a predetermined cone angle, numerical aperture, and F-number. The system also includes a spatially-dependent, angular light modulator (ALM) with a plurality of pixels, each having an ON state, an OFF state, one input pupil, and N diffraction order pupils. The ALM is positioned such that the output beam is incident on the plurality of pixels. The at least one of the predetermined cone angle, numerical aperture, and F-number of the illumination shaping optic elements prevents contaminating light from entering an incorrect pupil. The system additionally includes a processor coupled to the ALM to provide discrete diffraction-based beam steering, whereby the ALM will project into one diffraction order at one time.
-
公开(公告)号:US20240062548A1
公开(公告)日:2024-02-22
申请号:US18236842
申请日:2023-08-22
发明人: Kavan Hazeli , Bahram Jalali , Janet Roveda
摘要: A life-assisting system to enhance the quality of life for people with visual impairment. The system integrates state-of-the-art sensing and sensory stimulation with light detection and ranging (LiDAR), machine learning, and advanced haptic navigation to provide the visually impaired population with a real-time haptic map of the three-dimensional environment and auditory descriptions of objects within that environment. By allowing the visually impaired population to sense objects in the surrounding environment through haptic and auditory feedback, the disclosed system has the potential to promote individual independence, reduce anxiety and stress, facilitate access to educational and employment opportunities, and reduce social and economic gaps. To provide those benefits, the system uses multi-modal learning to convert higher dimensional (e.g., four-dimensional) scene data into lower dimensional (e.g., one-dimensional) auditory data and (e.g., two- or three-dimensional) haptic data.
-
33.
公开(公告)号:US20240061085A1
公开(公告)日:2024-02-22
申请号:US18235617
申请日:2023-08-18
IPC分类号: G01S7/481 , G01S7/4865
CPC分类号: G01S7/4817 , G01S7/4814 , G01S7/4816 , G01S7/4865
摘要: A LIDAR system includes a laser source configured to generate laser light pulses, a first DMD, a second DMD and a two-dimensional (2D) sensor array. The first DMD is configured to receive the laser light pulses and diffractively steer the light pulses to sequentially illuminate different sub-regions within the extended region. The second DMD is configured to receive reflected light pulses from the different sub-regions in a sequential manner as each of the different sub-regions is illuminated by the light pulses. The 2D sensor array configured to receive reflected light pulses from the second DMD and form an image of the different sub-regions as the reflected light pulses from each of the different sub-regions is sequentially received from the second DMD.
-
公开(公告)号:US11904054B2
公开(公告)日:2024-02-20
申请号:US16963043
申请日:2019-01-18
发明人: Heidi M. Mansour , Stephen Black , Maria Acosta
IPC分类号: A61K9/16 , A61K9/00 , A61K9/51 , A61K31/366 , A61K31/047 , A61K31/221 , A61K45/06 , B82Y5/00
CPC分类号: A61K9/1682 , A61K9/0075 , A61K9/5192 , A61K31/366 , A61K31/047 , A61K31/221 , A61K45/06 , B82Y5/00
摘要: Provided herein are compositions and methods for treating respiratory and pulmonary vascular disease. In particular, provided herein are spray dried simvastatin for delivery to the lung.
-
公开(公告)号:US20240039237A1
公开(公告)日:2024-02-01
申请号:US18245841
申请日:2021-09-17
发明人: Yushi Kaneda
CPC分类号: H01S3/2341 , H01S3/10061 , H01S2301/02
摘要: The described methods and devices minimize or reduce the effects of the leading amplified spontaneous emission component of an optical pulse in optical multi-pass amplifier systems. One multi-pass optical amplifier includes a gain medium positioned to receive a pump laser, and to receive an optical pulse having a main component and one or both of a leading or a trailing component. The optical amplifier also includes one or more reflectors positioned at a first side or at a second side of the gain medium that allow multi-pass propagation of the optical pulse through the gain medium. The one or more reflectors are positioned to allow the main component of the optical pulse to traverse through the gain medium in a first pass before the leading component of the optical pulse reaches the gain medium in a second pass through the gain medium.
-
公开(公告)号:US20240002457A1
公开(公告)日:2024-01-04
申请号:US18037098
申请日:2021-11-16
IPC分类号: C07K14/435 , A23K20/147 , A23K20/189 , A23K50/80 , C12N9/16 , C12N9/48 , C12Q1/6883
CPC分类号: C07K14/43509 , A23K20/147 , A23K20/189 , A61K38/00 , C12N9/16 , C12N9/485 , C12Q1/6883 , A23K50/80
摘要: Described herein are proteins and fragments thereof that can be capable of binding or otherwise interacting with a Vibrio species toxin. The Vibrio toxin binding proteins and fragments thereof can be included in a formulation, such as a feed formulation, that can be used to treat and/or prevent Vibrio spp. disease or a symptom thereof, such as AHPND. Also described herein are AHPND susceptibility signatures that can be useful for identification of susceptible and/or resistant/tolerant organisms.
-
公开(公告)号:US20240002437A1
公开(公告)日:2024-01-04
申请号:US18251078
申请日:2021-10-25
发明人: Stephen M. Black , Evgeny A. Zemskov , Qing Lu
CPC分类号: C07K5/1021 , A61P11/00 , A61K38/00
摘要: It has been discovered that phosphorylation-dependent uncoupling of endothelial nitric oxide synthase (eNOS) plays an important role in endothelial cell (EC) barrier disruption. Compositions and methods to reduce or prevent eNOS uncoupling are disclosed. Decoy peptides that can prevent phosphorylation and mitochondrial redistribution of eNOS, reduce eNOS uncoupling, and preserve EC barrier function, and uses thereof, are described. The peptides improve lung vascular integrity in a mouse model of VILI. Thus, the decoy peptides can be used to treat or prevent diseases or disorders associated with increased vascular permeability such as ALI, ARDS, and VILI.
-
公开(公告)号:US20230414655A1
公开(公告)日:2023-12-28
申请号:US18209618
申请日:2023-06-14
发明人: Vance G. Nielsen
摘要: This invention relates to compositions and methods for treating, ameliorating, and preventing the toxic effects of venom poisoning. In particular, the invention provides compositions comprising one or more ruthenim based-agents for one or more of inhibiting venom related procoagulant activity, inhibiting venom related phospholipase A2 (PLA2), and/or inhibiting venom related thrombus generation, and related methods for treating, ameliorating and preventing the toxic effects of venom poisoning in a subject suffering from or at risk of suffering from venom poisoning.
-
公开(公告)号:US20230405130A1
公开(公告)日:2023-12-21
申请号:US18035573
申请日:2021-11-05
申请人: Arizona Board of Regents on Behalf of the University of Arizona , The Penn State Research Foundation
IPC分类号: A61K47/54 , C12N15/113 , A61K31/713
CPC分类号: A61K47/545 , C12N15/113 , A61K31/713 , C12N2310/11 , C12N2320/32 , C12Y207/07007
摘要: Provided herein are compositions and methods for treating and preventing bacterial infections. In particular, provided herein are targeted bola-amphiphile: nucleic acid complexes specific for bacteria.
-
公开(公告)号:US11846828B2
公开(公告)日:2023-12-19
申请号:US16969547
申请日:2019-02-08
发明人: Laird M. Close , Maggie Y. Kautz
CPC分类号: G02B7/1825 , F16B2/065 , G02B7/181
摘要: A stabilizing locking clamp for a kinematic optical mount includes a clamp plate configured for optical access and a plurality of clamp actuators affixed to the clamp plate. The clamp actuators are positioned such that each clamp actuator exerts a force on a front plate of the kinematic optical mount in a push-push configuration. A stabilizing kinematic optical mount includes a kinematic optical mount and a plurality of clamp arms, each clamp arm including a clamp actuator positioned to exert a force on a front plate of the kinematic optical mount in a push-push configuration. The stabilizing locking clamp and stabilizing kinematic optical mount reduce temperature-dependent and vibration-induced changes in pitch and yaw, thereby improving pointing stability for optical setups that rely on critical beam alignment.
-
-
-
-
-
-
-
-
-