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    AGONISTIC TNF RECEPTOR BINDING AGENTS
    33.
    发明申请
    AGONISTIC TNF RECEPTOR BINDING AGENTS 审中-公开

    公开(公告)号：US20180194849A1

    公开(公告)日：2018-07-12

    申请号：US15538419

    申请日：2016-01-08

    Applicant: BIONTECH AG ,  GENMAB A/S

    Inventor： Ugur Sahin ,  Friederike Gieseke ,  Isil Altintas ,  David Satijn ,  Paul Parren

    IPC: C07K16/28

    Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.

    Identification of tumor-associated cell surface antigens for diagnosis and therapy
    38.
    发明授权
    Identification of tumor-associated cell surface antigens for diagnosis and therapy 有权

    公开(公告)号：US09267177B2

    公开(公告)日：2016-02-23

    申请号：US14830506

    申请日：2015-08-19

    Applicant: BioNTech AG

    Inventor： Özlem Türeci ,  Ugur Sahin ,  Gerd Helftenbein ,  Volker Schlüter

    IPC: C12Q1/68

    CPC classification number: G01N33/57492 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/30 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2800/56

    Abstract: The present invention provides agents with tumor-inhibiting activity, and which are selective for cells expressing or abnormally expressing a tumor-associated antigen. Said tumor-associated antigen has a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence selected from the specific sequences set forth herein, or a 6-50 contiguous nucleotide residue portion thereof; (b) a nucleotide sequence of a nucleic acid which hybridizes with a nucleic acid having the nucleotide sequence of (a) under stringent conditions; (c) a nucleotide sequence which is degenerate with respect to the nucleotide sequence of (a) or (b); and (d) a nucleotide sequence which is complementary to the nucleotide sequence of (a), (b) or (c). Pharmaceutical compositions and kits comprising the agents are also provided, as well as methods treating, diagnosing or monitoring a disease characterized by expression or abnormal expression of the tumor-associated antigen.

    Identification of Surface-Associated Antigens for Tumor Diagnosis and Therapy
    39.
    发明申请
    Identification of Surface-Associated Antigens for Tumor Diagnosis and Therapy 有权
    鉴定表面相关抗原的肿瘤诊断和治疗

    公开(公告)号：US20140120085A1

    公开(公告)日：2014-05-01

    申请号：US14036969

    申请日：2013-09-25

    Applicant: BioNTech AG

    Inventor： Özlem TÜRECI ,  Ugur SAHIN ,  Sandra SCHNEIDER ,  Gerd HELFTENBEIN ,  Volker SCHLÜTER ,  Dirk USENER ,  Philippe THIEL ,  Michael KOSLOWSKI

    IPC: C07K14/47

    CPC classification number: A61K39/39558 ,  A61K39/395 ,  A61K45/06 ,  C07K14/4748 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/53

    Abstract: An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.

    Abstract translation: 本发明的分离的截短的脱骨髓蛋白4（DSG4）多肽剪接变体的特征在于缺乏在具有SEQ ID NO：75的多核苷酸序列的DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。还公开了 是在患者中诊断癌症或监测其过程的方法。 该方法包括在患者的组织样品中检测包含由具有SEQ ID NO：75的多核苷酸序列的DSG4基因或截短的DSG4多肽剪接变体编码的DSG4多肽的细胞外结构域的肿瘤相关抗原的表达 其特征在于缺乏在DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。

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