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公开(公告)号：US07695962B2
公开(公告)日：2010-04-13
申请号：US12132350
申请日：2008-06-03
Applicant: Arnold J. Levine , Diane Pennica
Inventor： Arnold J. Levine , Diane Pennica
CPC classification number: G01N33/57484 , C07K14/47 , C07K2317/24 , C07K2319/02 , G01N33/68
Abstract: DNAs are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
Abstract translation: 提供DNA，其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。
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公开(公告)号：US07687460B2
公开(公告)日：2010-03-30
申请号：US10399093
申请日：2001-10-12
Applicant: Luc Desnoyer , Ellen H. Filvaroff , Diane Pennica
Inventor： Luc Desnoyer , Ellen H. Filvaroff , Diane Pennica
IPC: A61K38/00
CPC classification number: C07K14/475 , A61K38/00 , C07K14/47
Abstract: The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration may be in combination with one or more cartilage agents (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of WISP polypeptide in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of WISP polypeptide.
Abstract translation: 本发明涉及软骨的治疗和修复方法，包括损伤的软骨或包括关节炎在内的退行性软骨疾病，包括施用WISP多肽。 任选地，给药可以与一种或多种软骨剂（例如肽生长因子，分解代谢拮抗剂，骨，滑膜，抗炎因子）组合。 或者，该方法提供了由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括与标准手术技术组合施用WISP多肽。 或者，该方法提供对由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括施用有效量的WISP多肽以前治疗的软骨细胞。
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33.发明授权公开(公告)号：US07566536B2
公开(公告)日：2009-07-28
申请号：US10614599
申请日：2003-07-07
Applicant: David P. Andrew , David A. Lewin , Diane Pennica , Luca Rastelli , Bruce Tallion
Inventor： David P. Andrew , David A. Lewin , Diane Pennica , Luca Rastelli , Bruce Tallion
Abstract: The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.
Abstract translation: 本发明提供了称为FCTRX多肽的新型多肽，以及编码FCTRX多肽的多核苷酸和免疫特异性结合FCTRX或FCTRX多肽，多核苷酸或抗体的衍生物，变体，突变体或片段的抗体。 本发明还提供了FCTRX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。
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公开(公告)号：US20080299547A1
公开(公告)日：2008-12-04
申请号：US11458181
申请日：2006-07-18
Applicant: Diane Pennica , Victoria Smith , William I. Wood
Inventor： Diane Pennica , Victoria Smith , William I. Wood
IPC: C12Q1/68 , G01N33/574 , G01N33/00 , C12Q1/02
CPC classification number: C12N15/1034 , A61K38/1709 , A61K2039/505 , C07K14/47 , C07K2319/00 , C12N15/85 , G01N33/574 , A61K2300/00
Abstract: The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及与Stra6，鼠视黄酸反应性蛋白质以及编码这些多肽的核酸分子具有序列相似性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20070128188A1
公开(公告)日：2007-06-07
申请号：US11438488
申请日：2006-05-22
Applicant: Diane Pennica , Victoria Smith , William Wood
Inventor： Diane Pennica , Victoria Smith , William Wood
IPC: A61K39/395 , C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/30 , A61K31/203
CPC classification number: C12N15/1034 , A61K38/1709 , A61K2039/505 , C07K14/47 , C07K2319/00 , C12N15/85 , G01N33/574 , A61K2300/00
Abstract: The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及与Stra6，鼠视黄酸反应性蛋白质以及编码这些多肽的核酸分子具有序列相似性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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Patent Agency Ranking
公开(公告)号：US07173115B2
公开(公告)日：2007-02-06
申请号：US09759056
申请日：2001-01-11
Applicant: Diane Pennica , Victoria Smith , William I. Wood
Inventor： Diane Pennica , Victoria Smith , William I. Wood
CPC classification number: C12N15/1034 , A61K38/1709 , A61K2039/505 , C07K14/47 , C07K2319/00 , C12N15/85 , G01N33/574 , A61K2300/00
Abstract: The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及与Stra6，鼠视黄酸反应性蛋白质以及编码这些多肽的核酸分子具有序列相似性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20050054563A1
公开(公告)日：2005-03-10
申请号：US10399093
申请日：2001-10-12
Applicant: Luc Desnoyer , Ellen Filvaroff , Diane Pennica
Inventor： Luc Desnoyer , Ellen Filvaroff , Diane Pennica
CPC classification number: C07K14/475 , A61K38/00 , C07K14/47
Abstract: A transgenic bacterial host cell that can be used as a screen for novel antibiotics and herbicides is provided. The genome of the transgenic bacterial host cell comprises disruptions in a first endogenous gene in the MEP pathway) and a transgene that functionally replaces the disrupted first gene. In other embodiments, the genome comprises a disruption in a first endogenous gene in the MEP pathway and a second endogenous gene which is located downstream of the first gene in the MEP pathway. A transgene that functionally replaces the disrupted downstream gene is cloned into the host cell. A mini operon containing the essential genes for the MVA pathway may also be cloned into the host cell. The transgenic host cell may be used in a method for screening compounds for antibiotic and herbicidal properties. The agents determined by the screening method may be used to kill bacteria or plants.
Abstract translation: 提供了可用作新型抗生素和除草剂筛选的转基因细菌宿主细胞。 转基因细菌宿主细胞的基因组包括在MEP途径中的第一内源基因中的破坏）和在功能上替代被破坏的第一基因的转基因。 在其他实施方案中，基因组包含MEP途径中的第一内源基因的破坏和位于MEP途径中第一个基因下游的第二内源基因。 功能性替代被破坏的下游基因的转基因被克隆到宿主细胞中。 含有MVA途径必需基因的迷你操纵子也可以克隆到宿主细胞中。 转基因宿主细胞可用于筛选抗生素和除草性质的化合物的方法。 通过筛选方法测定的试剂可用于杀死细菌或植物。
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38.发明授权公开(公告)号：US06274335B1
公开(公告)日：2001-08-14
申请号：US09105698
申请日：1998-06-26
Applicant: David V. Goeddel , William J. Kohr , Diane Pennica , Gordon A. Vehar
Inventor： David V. Goeddel , William J. Kohr , Diane Pennica , Gordon A. Vehar
IPC: C12Q156
CPC classification number: C12N15/71 , A61K38/00 , C12N9/003 , C12N9/6459 , C12Y304/21069
Abstract: Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.
Abstract translation: 使用重组DNA技术以有用的量产生人组织纤溶酶原激活物（t-PA）。 因此，所公开的发明使得能够生产没有其天然细胞环境中通常相关的污染物的t-PA。 还公开了可用于其生产的方法，表达载体和各种宿主细胞。
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公开(公告)号：US5268291A
公开(公告)日：1993-12-07
申请号：US663103
申请日：1991-02-28
Applicant: Arthur D. Levinson , Diane Pennica , William J. Kohr , Gordon A. Vehar , David V. Goeddel , Christian C. Simonsen
Inventor： Arthur D. Levinson , Diane Pennica , William J. Kohr , Gordon A. Vehar , David V. Goeddel , Christian C. Simonsen
CPC classification number: C12N9/0028 , C12N15/85 , C12N9/6459 , C12Y304/21069 , C12N2800/108 , C12N2830/00 , C12N2830/55
Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.
Abstract translation: 公开了一种在真核宿主细胞中产生组织纤溶酶原激活物（t-PA）的方法。 通过用甲氨蝶呤处理用突变体或野生型DHFR转化的培养物共同扩增t-PA基因，获得增强的t-PA产生水平。
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公开(公告)号：US4853330A
公开(公告)日：1989-08-01
申请号：US184477
申请日：1988-04-21
Applicant: David V. Goeddel , William J. Kohr , Diane Pennica , Gordon A. Vehar
Inventor： David V. Goeddel , William J. Kohr , Diane Pennica , Gordon A. Vehar
CPC classification number: C12N9/003 , C12N15/71 , C12N9/6459 , C12Y304/21069 , A61K38/00 , Y10S930/26
Abstract: Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.
Abstract translation: 使用重组DNA技术以有用的量产生人组织纤溶酶原激活物（t-PA）。 因此，所公开的发明使得能够生产没有其天然细胞环境中通常相关的污染物的t-PA。 还公开了可用于其生产的方法，表达载体和各种宿主细胞。
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