利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

50 条记录 (耗时 0.035 秒)

    STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES
    32.
    发明申请
    STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
    稳定的非酒精泡沫药物组合物与联合动物及其用途

    公开(公告)号：US20110097279A1

    公开(公告)日：2011-04-28

    申请号：US12974857

    申请日：2010-12-21

    申请人： Dov TAMARKIN ,  Meir EINI ,  Doron FRIEDMAN ,  David SCHUZ ,  Tal BERMAN

    发明人： Dov TAMARKIN ,  Meir EINI ,  Doron FRIEDMAN ,  David SCHUZ ,  Tal BERMAN

    IPC分类号： A61K9/12 ,  A61P17/00 ,  A61K8/06 ,  A61Q19/00

    CPC分类号： A61K9/0014 ,  A61K8/046 ,  A61K8/39 ,  A61K8/731 ,  A61K8/86 ,  A61K9/1075 ,  A61K9/122 ,  A61Q7/00 ,  A61Q19/00

    摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.

    摘要翻译： 稳定的非醇可发泡药物乳液组合物包含浓度为约0.5％至约49％（重量）的单一润肤剂; 至少一种多活性剂; 浓度为约0.5％至约15％重量; 水; 有效量的在乳液组合物中具有溶解度的活性药剂; 和至少一种浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述柔性润肤剂单独包含凡士林或与其它浮游剂组合; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中在两个所述乳化剂的HLB值之间存在约4个或更多个单元的差异，或者化学性质存在显着差异 或结构的两个emulgators; （b）表面活性剂和泡沫助剂或助表面活性剂，其中表面活性剂具有接近油相所需HLB的HLB; （c）表面活性剂和液体蜡，其中所述表面活性剂具有接近所述油相所需HLB的HLB; （d）除淀粉或改性淀粉酯以外的表面活性剂和聚合物，其中所述表面活性剂具有接近油相所需HLB的HLB; （e）聚合剂和泡沫助剂或助表面活性剂，其可以配合以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由具有接近油相所需HLB的HLB的酯的混合物组成; 并且其中组合物基本可流动的组合物储存在加压容器中并且当释放时膨胀以形成可破裂的泡沫。

    DEVICE FOR DELIVERY OF A FOAMABLE COMPOSITION
    33.
    发明申请
    DEVICE FOR DELIVERY OF A FOAMABLE COMPOSITION 有权
    用于输送可发泡组合物的装置

    公开(公告)号：US20090068118A1

    公开(公告)日：2009-03-12

    申请号：US12204771

    申请日：2008-09-04

    申请人： Meir EINI ,  David SCHUZ ,  Helen SHIFRIN ,  Yohan HAZOT ,  Dov TAMARKIN

    发明人： Meir EINI ,  David SCHUZ ,  Helen SHIFRIN ,  Yohan HAZOT ,  Dov TAMARKIN

    IPC分类号： A61K9/12 ,  A61M31/00

    CPC分类号： A61M31/00

    摘要： A device for delivery of a foamable composition to a body cavity includes a pressurized composition reservoir; a hollow body having a longitudinally extending wall and having at least one aperture provided through a wall of said body, the proximal end in fluid communication with the reservoir for receiving a foamable composition from said composition reservoir; and an actuator operatively connected to the composition reservoir for effecting release of a foamable composition from said composition reservoir into a body cavity through said hollow body; wherein said body has a length less than about 125 mm and internal diameter in the range of about 1.5 mm to about 3.5 mm, wherein said length and internal diameter are selected to provide a delivery of at least about 70% of the foamable composition during operation. The foam delivery device can have multiple apertures.

    摘要翻译： 用于将可发泡组合物递送到体腔的装置包括加压组合物储存器; 具有纵向延伸的壁并具有通过所述主体的壁设置的至少一个孔的空心体，所述近端与所述储存器流体连通以从所述组合物储存器接收可发泡组合物; 以及致动器，其可操作地连接到所述组合物储存器，用于通过所述中空体从所述组合物储存器中释放可发泡组合物到体腔中; 其中所述主体具有小于约125mm的长度，并且内径在约1.5mm至约3.5mm的范围内，其中所述长度和内径被选择为在操作期间提供至少约70％的可发泡组合物的输送 。 泡沫输送装置可以具有多个孔。

    STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES
    34.
    发明申请
    STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
    稳定的非酒精泡沫药物组合物与联合动物及其用途

    公开(公告)号：US20080206155A1

    公开(公告)日：2008-08-28

    申请号：US11940290

    申请日：2007-11-14

    申请人： Dov TAMARKIN ,  Meir EINI ,  Doron FRIEDMAN ,  David SCHUZ ,  Tal BERMAN

    发明人： Dov TAMARKIN ,  Meir EINI ,  Doron FRIEDMAN ,  David SCHUZ ,  Tal BERMAN

    IPC分类号： A61K9/12

    CPC分类号： A61K9/0014 ,  A61K8/046 ,  A61K8/39 ,  A61K8/731 ,  A61K8/86 ,  A61K9/1075 ,  A61K9/122 ,  A61Q7/00 ,  A61Q19/00

    摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.

    摘要翻译： 稳定的非醇可发泡药物乳液组合物包含浓度为约0.5％至约49％（重量）的单一润肤剂; 至少一种多活性剂; 浓度为约0.5％至约15％重量; 水; 有效量的在乳液组合物中具有溶解度的活性药剂; 和至少一种浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述柔性润肤剂单独包含凡士林或与其它浮游剂组合; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中在两个所述乳化剂的HLB值之间存在约4个或更多个单元的差异，或者化学性质存在显着差异 或结构的两个emulgators; （b）表面活性剂和泡沫助剂或助表面活性剂，其中表面活性剂具有接近油相所需HLB的HLB; （c）表面活性剂和液体蜡，其中所述表面活性剂具有接近所述油相所需HLB的HLB; （d）除淀粉或改性淀粉酯以外的表面活性剂和聚合物，其中所述表面活性剂具有接近油相所需HLB的HLB; （e）聚合剂和泡沫助剂或助表面活性剂，其可以配合以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由具有接近所述油相所需HLB的HLB的酯的混合物组成; 并且其中组合物基本可流动的组合物储存在加压容器中并且当释放时膨胀以形成可破裂的泡沫。