中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

68 records (took 0.02 seconds)

    IMMUNOMODULATORY FUSION PROTEINS
    32.
    发明申请
    IMMUNOMODULATORY FUSION PROTEINS 有权

    公开(公告)号：US20210139560A1

    公开(公告)日：2021-05-13

    申请号：US17150993

    申请日：2021-01-15

    Applicant: EpicentRx, Inc.

    Inventor： Christopher LARSON ,  Tony R. REID ,  Bryan T. ORONSKY

    IPC: C07K14/71 ,  C12N7/00 ,  A61P35/00 ,  C07K16/00 ,  C12N15/86

    Abstract: Provided is a fusion protein, e.g., a cytokine receptor fusion protein, e.g., a TGFβ trap, with a novel linker sequence to permit the fusion protein to functionally optimally, e.g., to permit a cytokine receptor portion of a cytokine receptor fusion protein to bind optimally to its target cytokine. The fusion proteins, or expression vectors encoding for the fusion proteins, e.g., oncolytic adenoviral expression vectors, can be used to treat cell proliferative diseases and disorders, including certain forms of cancer and inflammatory disorders.

    METHODS AND COMPOSITIONS UTILIZING RRx-001 COMBINATION THERAPY FOR RADIOPROTECTION
    33.
    发明申请
    METHODS AND COMPOSITIONS UTILIZING RRx-001 COMBINATION THERAPY FOR RADIOPROTECTION 审中-公开

    公开(公告)号：US20200345690A1

    公开(公告)日：2020-11-05

    申请号：US16960444

    申请日：2019-01-08

    Applicant: EpicentRx Inc.

    Inventor： Bryan T. ORONSKY ,  Amold ORONSKY ,  Tony R. REID

    IPC: A61K31/397

    Abstract: Provided herein are therapeutic methods, kits, and pharmaceutical compositions for protecting a subject from radiation using a therapeutic agent selected from the group consisting of RRx-OO1 and a pharmaceutically acceptable salt thereof. One exemplary therapeutic method involves administering RRx-OO1 to the subject prior to the subject being exposed to the radiation, in order to protect the subject against radiation, such as ionizing radiation containing α-rays, β-rays, γ-rays, neutron radiation, or a combination thereof.

    MEDICATION INFUSION DEVICES, SYSTEMS, AND METHODS
    39.
    发明申请
    MEDICATION INFUSION DEVICES, SYSTEMS, AND METHODS 有权

    公开(公告)号：US20250161548A1

    公开(公告)日：2025-05-22

    申请号：US18748892

    申请日：2024-06-20

    Applicant: EpicentRx, Inc.

    Inventor： Bryan T. ORONSKY ,  Scott CAROEN ,  Tony R. REID ,  Jeannie WILLIAMS

    IPC: A61M1/34 ,  A61M1/36 ,  A61M1/38

    Abstract: Devices, systems, and methods for medication infusion are described herein. In some embodiments, a system includes a patient access subassembly, a first fluid reservoir, a second fluid reservoir, and an assembly. The assembly can have a first configuration in which the patient access subassembly is in fluid communication with the first fluid reservoir via a first tube, a second configuration in which the first fluid reservoir is in fluid communication with the second fluid reservoir, and a third configuration in which the first fluid reservoir is in fluid communication with the patient access subassembly via a second tube, the first fluid reservoir fluidically isolated from the first tube in the third configuration.

Patent Agency Ranking