公开(公告)号：US20140038975A1

公开(公告)日：2014-02-06

申请号：US14110165

申请日：2012-03-27

Applicant: Matthew Frank Brown ,  Jinshan Michael Chen ,  Michael Joseph Melnick ,  Justin Ian Montgomery ,  Usa Reilly

Inventor： Matthew Frank Brown ,  Jinshan Michael Chen ,  Michael Joseph Melnick ,  Justin Ian Montgomery ,  Usa Reilly

IPC: C07D413/10 ,  C07D249/06 ,  C07D413/04 ,  C07D233/61 ,  C07D231/12 ,  C07D403/04

CPC classification number: C07D413/10 ,  A61K31/4192 ,  C07D231/12 ,  C07D233/61 ,  C07D249/06 ,  C07D403/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  Y02A50/473

Abstract: The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract translation: 本发明涉及一类新的异羟肟酸衍生物，它们用作LpxC抑制剂，更具体地，其用于治疗细菌感染。

公开(公告)号：US20120258948A1

公开(公告)日：2012-10-11

申请号：US13515607

申请日：2010-12-06

Applicant: Matthew Frank Brown ,  Ye Che ,  Anthony Marfat ,  Michael Joseph Melnick ,  Justin Ian Montgomery ,  Usa Reilly

Inventor： Matthew Frank Brown ,  Ye Che ,  Anthony Marfat ,  Michael Joseph Melnick ,  Justin Ian Montgomery ,  Usa Reilly

IPC: A61K31/4412 ,  A61K31/4439 ,  C07D213/64 ,  C07D401/12 ,  A61K31/4545 ,  A61K31/4418 ,  C07D405/10 ,  A61K31/4433 ,  A61K31/506 ,  C07D413/10 ,  C07D213/643 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/4427 ,  C07D401/14 ,  C07D417/12 ,  A61K31/541 ,  C07D413/12 ,  A61K31/5377 ,  A61P31/04 ,  C07D401/10

CPC classification number: A61K31/4412 ,  A61K31/4439 ,  C07D211/86 ,  C07D213/64 ,  C07D401/04 ,  C07D401/08 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D409/04 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/10 ,  C07D417/12 ,  Y02A50/473

Abstract: The present invention is directed to a new class of hydroxamic acid derivatives of formula I, wherein the variables G, T, D, L, R1, R2, R3 are as described herein, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections in a patient in need thereof.

Abstract translation: 本发明涉及一类新的式I的异羟肟酸衍生物，其中变量G，T，D，L，R 1，R 2，R 3如本文所述，它们作为LpxC抑制剂的用途，更具体地说， 在有需要的患者中治疗细菌感染。

公开(公告)号：US20100291907A1

公开(公告)日：2010-11-18

申请号：US12733724

申请日：2008-09-17

Applicant: Malcolm David MacNaughtan ,  Christopher Ridgway Drane ,  Craig Andrew Scott ,  Stephen Frank Brown

Inventor： Malcolm David MacNaughtan ,  Christopher Ridgway Drane ,  Craig Andrew Scott ,  Stephen Frank Brown

IPC: H04W4/02 ,  A63F9/24 ,  G06Q30/00

CPC classification number: G06Q30/0241 ,  H04L67/04 ,  H04L67/18 ,  H04L67/20 ,  H04M3/4878 ,  H04W4/02 ,  H04W4/021 ,  H04W4/21 ,  H04W8/20

Abstract: Systems, methods and devices for monitoring the location of mobile radio terminal users for the purpose of detecting when they approach within range of one or more target locations in order to trigger voice and/or data communications to or from the network or other mobile radio terminals.

Abstract translation: 用于监视移动无线终端用户的位置的系统，方法和设备，用于检测何时它们在一个或多个目标位置的范围内接近以触发到网络或其他移动无线电终端的语音和/或数据通信 。

公开(公告)号：US20100248640A1

公开(公告)日：2010-09-30

申请号：US12734812

申请日：2008-11-26

Applicant: Malcolm David MacNaughtan ,  Christopher Ridgway Drane ,  Stephen Frank Brown ,  Craig Andrew Scott

Inventor： Malcolm David MacNaughtan ,  Christopher Ridgway Drane ,  Stephen Frank Brown ,  Craig Andrew Scott

IPC: H04B17/00

CPC classification number: H04W4/02 ,  H04W8/18

Abstract: Methods and systems of updating a zone profile comprising obtaining a plurality of radio signal parameter measurements and, if the plurality of radio signal parameter measurements contains at least one measurement corresponding to a dominant element of the zone profile and if the plurality of radio signal parameter measurements contains at least one measurement corresponding to a candidate element (e.g., statistically unlikely element) of the zone profile, updating the profile by either adjusting an existing parameter value or by adding a new element to the zone profile corresponding to the candidate element.

Abstract translation: 更新区域简档的方法和系统包括获得多个无线电信号参数测量值，并且如果所述多个无线电信号参数测量值包含对应于所述区域简档的主要元素的至少一个测量值，并且如果所述多个无线电信号参数测量值 包含对应于区域轮廓的候选元素（例如，统计上不可能的元素）的至少一个测量值，通过调整现有参数值或通过将新元素添加到与候选元素相对应的区域轮廓来更新轮廓。

公开(公告)号：US20100120794A1

公开(公告)日：2010-05-13

申请号：US12651885

申请日：2010-01-04

Applicant: Samit Kumar Bhattacharya ,  Matthew Frank Brown ,  Peter Hans Dorff ,  Susan LaGreca

Inventor： Samit Kumar Bhattacharya ,  Matthew Frank Brown ,  Peter Hans Dorff ,  Susan LaGreca

IPC: A61K31/497 ,  C07D413/04 ,  A61K31/4439 ,  C07D417/04 ,  A61P37/00 ,  A61P19/02 ,  A61P3/10 ,  A61P1/00 ,  A61P29/00 ,  A61P11/06 ,  A61P9/10 ,  A61K31/506 ,  C07D271/06 ,  A61K31/4245 ,  A61K31/4436

CPC classification number: C07D213/38 ,  C07D271/06 ,  C07D271/10 ,  C07D271/107 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04

Abstract: The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R1, R2, R3, R4, R5, R8, m, n, p, q, r, s, t and u are as defined herein. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐，前体药物，溶剂合物或水合物; 其中B，D，E，R 1，R 2，R 3，R 4，R 5，R 8，m，n，p，q，r，s，t和u如本文所定义。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类的过度增殖性疾病和自身免疫性疾病的方法，以及含有这些化合物的药物组合物。

公开(公告)号：US20070174438A9

公开(公告)日：2007-07-26

申请号：US10734725

申请日：2003-12-12

Applicant: Daniel Johnson ,  James Peterson ,  Robert McConnell ,  Frank Brown

Inventor： Daniel Johnson ,  James Peterson ,  Robert McConnell ,  Frank Brown

IPC: G06F15/173

CPC classification number: G05B15/02

Abstract: A system for receiving and normalizing notification events from assets or equipment located at various sites within an enterprise is disclosed. The system includes receiving a notification, identifying the protocol used by the equipment sending the notification, and converting the notification to a normalized format. The system allows notifications from various types of equipment or assets to be handled by one enterprise management system.

Abstract translation: 披露了一种系统，用于从位于企业内各个场所的资产或设备接收和规范化通知事件。 该系统包括接收通知，识别由发送通知的设备使用的协议，并将该通知转换为归一化格式。 该系统允许来自各种类型的设备或资产的通知由一个企业管理系统来处理。

公开(公告)号：US20060130501A1

公开(公告)日：2006-06-22

申请号：US11260878

申请日：2005-10-27

Applicant: Abtar Singh ,  Thomas Mathews ,  Frank Brown ,  Ozgur Gurkan

Inventor： Abtar Singh ,  Thomas Mathews ,  Frank Brown ,  Ozgur Gurkan

IPC: F25B39/04

CPC classification number: F25B49/027 ,  F25B2400/075 ,  F25B2400/22 ,  F25B2600/111 ,  F25B2700/15 ,  F25B2700/151 ,  F25B2700/1931 ,  F25B2700/1933 ,  F25B2700/195 ,  F25B2700/2106 ,  F25B2700/21151 ,  F25B2700/2116 ,  Y02B30/743

Abstract: A controller comprises a first input that receives a signal indicating an energy consumption value of a compressor, a second input that receives a signal indicating an energy consumption value of a variable speed condenser fan, and an output that provides a control signal to the variable speed condenser fan. The controller also comprises a memory that stores a condenser set point, and a processor in communication with the input, output and memory and that modulates the condenser set-point to minimize energy consumption and controls the variable speed condenser fan based on the condenser set-point.

Abstract translation: 控制器包括接收指示压缩机的能量消耗值的信号的第一输入端，接收指示可变速冷凝器风扇的能量消耗值的信号的第二输入端以及向变速器提供控制信号的输出 冷凝器风扇 控制器还包括存储冷凝器设定点的存储器和与输入，输出和存储器通信的处理器，并且调节冷凝器设定点以最小化能量消耗，并且基于冷凝器设定点控制可变速冷凝器风扇， 点。

公开(公告)号：US20050203092A1

公开(公告)日：2005-09-15

申请号：US10987562

申请日：2004-11-12

Applicant: Elfrida Benjamin ,  Frank Brown ,  Robert Zivin ,  Michael McMillan ,  Zhong Zhong ,  Allen Reitz ,  Tina Ross

Inventor： Elfrida Benjamin ,  Frank Brown ,  Robert Zivin ,  Michael McMillan ,  Zhong Zhong ,  Allen Reitz ,  Tina Ross

IPC: C07D239/12 ,  C07D239/42 ,  C07D239/52 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D495/04 ,  C07D413/02 ,  A61K31/506 ,  A61K31/5377 ,  C07D43/02

CPC classification number: C07D239/42 ,  C07D239/12 ,  C07D239/52 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D495/04

Abstract: This invention provides novel neuroprotective 4-pyrimidineamine derivatives and neuroprotective pharmaceutical compositions comprising 4-pyrimidinamines. This invention also provides methods of using these compositions to prevent ischemic cell death, particularly neuronal cell death, and reduce the likelihood of neuronal cell death in a subject due to a traumatic event. Finally, this invention provides an apparatus for administering to a subject the instant pharmaceutical compositions.

Abstract translation: 本发明提供新颖的神经保护性4-嘧啶胺衍生物和包含4-嘧啶胺的神经保护药物组合物。 本发明还提供了使用这些组合物来预防缺血性细胞死亡，特别是神经元细胞死亡并降低由于创伤性事件导致受试者神经元细胞死亡的可能性的方法。 最后，本发明提供了一种向受试者施用本发明的药物组合物的装置。

公开(公告)号：USPP11306P

公开(公告)日：2000-03-21

申请号：US114123

申请日：1998-07-13

Applicant: B. Frank Brown ,  Cleofar P. Millare

Inventor： B. Frank Brown ,  Cleofar P. Millare

Abstract: A new and distinct cultivar of Aglaonema named `Cassandra` particularly characterized by its upright and outwardly arching plant habit; uniform plant habit; good production of divisions; short internodes with numerous leaves giving plants a very full and dense appearance; upper leaf surfaces that are glossy silver green with dark green random spots and whitish-green to white midrib; large, oblong, flat leaves with white petioles which contrast well with the leaves; tolerance to low temperatures; and resistance to diseases common to Aglaonema.

公开(公告)号：US06006465A

公开(公告)日：1999-12-28

申请号：US982565

申请日：1997-12-02

Applicant: Frank Brown ,  Richard W. Brown ,  Richard M. Brown

Inventor： Frank Brown ,  Richard W. Brown ,  Richard M. Brown

IPC: A01K85/00

CPC classification number: A01K85/00

Abstract: A soft-bodied crank-bait lure comprising a rigid interior skeleton and a rubbery body molded or formed thereover, where the skeleton includes: a first channel extending downward and rearward from the anterior end of the lure; and a second channel extending downward and forward from the posterior end of the lure. The rearward opening of the first channel is spaced from and substantially faces the forward opening of the second channel, and the first channel and the second channel are angled with respect to each other. Fishing line or leader line is threaded through the first channel and then through second channel, and the hooks are coupled to the line rather than to the skeleton or to the rubbery body. Therefore, the lure will "free-flow" on the line, so that when a fish strikes the lure and becomes hooked, the lure will slide away from the fish. Furthermore, during the ensuing fight, when the line becomes taut, the angled alignment between the first and second channels will cause the lure will become substantially "locked" onto the line away from the fish.

Abstract translation: 柔软的曲柄诱饵包括刚性内部骨架和模制或形成在其上的橡胶体，其中骨架包括：从诱饵的前端向下和向后延伸的第一通道; 以及从诱饵的后端向下和向前延伸的第二通道。 第一通道的向后开口与第二通道的前开口间隔开并且基本上面对第二通道的前开口，并且第一通道和第二通道相对于彼此成角度。 钓鱼线或引导线穿过第一通道，然后穿过第二通道，并且钩被联接到线而不是骨架或橡胶体。 因此，诱惑会“自由流通”，所以当一只鱼撞上诱惑并被钩住时，诱惑会从鱼身上滑落。 此外，在随后的战斗中，当线条拉紧时，第一和第二通道之间的成角度对准将导致诱饵将基本上“锁定”在远离鱼的线上。