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    MICROORGANISMS FOR PRODUCING 1,3-BUTANEDIOL AND METHODS RELATED THERETO
    31.
    发明申请
    MICROORGANISMS FOR PRODUCING 1,3-BUTANEDIOL AND METHODS RELATED THERETO 有权

    公开(公告)号：US20210123078A1

    公开(公告)日：2021-04-29

    申请号：US16894600

    申请日：2020-06-05

    Applicant: Genomatica, Inc.

    Inventor： Anthony P. Burgard ,  Mark J. Burk ,  Robin E. Osterhout ,  Jun Sun ,  Priti Pharkya

    IPC: C12P7/18 ,  C12N15/52

    Abstract: Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway and comprising at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. In some embodiments, the pathway includes reducing equivalents from CO or hydrogen. In certain embodiments, a 1,3-BDO pathway proceeds by way of central metabolites pyruvate, succinate or alpha-ketoglutarate. Also provided herein is a method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

    FERMENTATION SYSTEMS AND METHODS WITH SUBSTANTIALLY UNIFORM VOLUMETRIC UPTAKE RATE OF A REACTIVE GASEOUS COMPONENT
    34.
    发明申请
    FERMENTATION SYSTEMS AND METHODS WITH SUBSTANTIALLY UNIFORM VOLUMETRIC UPTAKE RATE OF A REACTIVE GASEOUS COMPONENT 有权

    公开(公告)号：US20210079334A1

    公开(公告)日：2021-03-18

    申请号：US16965929

    申请日：2019-01-28

    Applicant: Genomatica, Inc.

    Inventor： Jason S. Crater ,  Jefferson Clay Lievense

    IPC: C12M1/00 ,  C12M1/02 ,  C12M1/36

    Abstract: Under one aspect, a fermentation system includes a fermentation vessel having a straight wall length L and an inner diameter D. The fermentation system also can include a source of a gas including a reactive gaseous component. The fermentation system also can include spargers spaced apart from one another along the straight wall length L of the fermentation vessel and configured to introduce bubbles of the gas into fermentation broth within the fermentation vessel. The release of the bubbles of the gas by each of the spargers can establish a respective mixing zone within the fermentation broth within the fermentation vessel. Each mixing zone can have substantially the same volumetric uptake rate of the reactive gaseous component by the fermentation broth as each other mixing zone.

    PROCESS OF SEPARATING COMPONENTS OF A FERMENTATION BROTH
    35.
    发明申请
    PROCESS OF SEPARATING COMPONENTS OF A FERMENTATION BROTH 有权

    公开(公告)号：US20210002194A1

    公开(公告)日：2021-01-07

    申请号：US16848430

    申请日：2020-04-14

    Applicant: Genomatica, Inc.

    Inventor： Warren Clark ,  Michael Japs ,  Mark J. Burk

    IPC: C07C29/76 ,  C12P7/18

    Abstract: A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.

    Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
    38.
    发明授权
    Semi-synthetic terephthalic acid via microorganisms that produce muconic acid 有权

    公开(公告)号：US10415063B2

    公开(公告)日：2019-09-17

    申请号：US16032772

    申请日：2018-07-11

    Applicant: GENOMATICA, INC.

    Inventor： Mark J. Burk ,  Robin E. Osterhout ,  Jun Sun

    IPC: C12P7/44 ,  C12N9/88

    Abstract: The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-CoA hydrolase, a beta-ketoadipyl-CoA transferase, a beta-ketoadipyl-CoA ligase, a 2-fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans-3-hydroxy-4-hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans-3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-CoA dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis-3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis-3-amino-4-hexendioate deaminase, and a muconate cis/trans isomerase. Other muconate pathway enzymes also are provided. Additionally provided are methods of producing muconate.

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