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    NUCLEIC ACID-CONTROLLED CATALYTIC RNAS FOR TRIGGER-RESPONSIVE REGULATION
    35.
    发明申请
    NUCLEIC ACID-CONTROLLED CATALYTIC RNAS FOR TRIGGER-RESPONSIVE REGULATION 有权

    公开(公告)号：US20240425855A1

    公开(公告)日：2024-12-26

    申请号：US18679965

    申请日：2024-05-31

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Simon AUSLAENDER ,  Ignazio GERACI

    IPC: C12N15/113 ,  C12N15/10

    Abstract: Herein is reported a composition comprising a pair of a first nucleic acid and a second nucleic acid, wherein the first nucleic acid comprises in the order a first part of a stem nucleic acid sequence, a cleavage site, a first stem loop nucleic acid sequences which 5′- and 3′-parts form a duplex, a first part of a catalytic core sequence, a second stem loop nucleic acid sequences which 5′- and 3′-parts form a duplex, a second part of the catalytic core sequence, and a second part of the stem nucleic acid sequence, which is complementary to the first part of the stem nucleic acid sequence and, thus, form a duplex therewith, wherein the second nucleic acid is complementary to at least a part of the first or the second part of the stem nucleic acid sequence, wherein binding of the second nucleic acid to the first nucleic acid results in a conformational change of the first nucleic acid, which is at least one of the dissociation of the first part of the first stem sequence from the second part of the stem sequence and the hybridization of one of the parts with the second nucleic acid, or the dissociation of loop I and loop II resulting in an inactivation of the catalytic activity, or the association of loop I and loop II resulting in an activation of the catalytic activity.

    RELATIVE MOVEMENT TRACKING WITH AUGMENTED REALITY
    38.
    发明申请
    RELATIVE MOVEMENT TRACKING WITH AUGMENTED REALITY 有权

    公开(公告)号：US20240412386A1

    公开(公告)日：2024-12-12

    申请号：US18702541

    申请日：2022-10-20

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Ralf Josef JAEGER ,  Xing CHEN

    IPC: G06T7/246 ,  G06F3/01 ,  G06T19/20

    Abstract: Systems and computer-implemented methods for tracking movement of a subject comprise and perform the steps of: Obtaining depth image data of a subject's body during a predefined time period and tracking locations of a plurality of anatomical landmarks of the body based on the depth image data. In addition, a location of a predefined point is tracked in an environment, in which the subject is moving. The location of the one or more of the plurality of anatomical landmarks is adjusted relative to the location of the predefined point to obtain adjusted locations. A movement of the subject's body is determined based on the adjusted locations during the predefined time period.

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