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31.发明授权公开(公告)号：US07183320B2
公开(公告)日：2007-02-27
申请号：US10478389
申请日：2002-05-24
Applicant: Chuan Shih , Cora Sue Grossman , Karen Lynn Lobb , Thomas Hughes Corbett , Ho-Shen Lin , Philip Arthur Hipskind
Inventor： Chuan Shih , Cora Sue Grossman , Karen Lynn Lobb , Thomas Hughes Corbett , Ho-Shen Lin , Philip Arthur Hipskind
IPC: A61K31/165 , C07C303/00
CPC classification number: C07D307/38 , A61K31/18 , C07C311/51 , C07C323/67 , C07D213/34 , C07D215/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/18
Abstract: The present invention provides antitumor compounds of the formula (I), and antitumor methods
Abstract translation: 本发明提供式（I）的抗肿瘤化合物和抗肿瘤方法
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公开(公告)号：US20060276522A1
公开(公告)日：2006-12-07
申请号：US10550006
申请日：2004-03-25
Applicant: Patrick Eacho , Patricia Foxworthy-Mason , Ho-Shen Lin , Jose Lopez , Marian Moslor , Michael Richett
Inventor： Patrick Eacho , Patricia Foxworthy-Mason , Ho-Shen Lin , Jose Lopez , Marian Moslor , Michael Richett
IPC: A61K31/425 , C07D275/04
CPC classification number: C07D275/04 , C07D417/12
Abstract: A novel class of benzisothiazole-3(2H)-one compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase mediated diseases. (I)
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公开(公告)号：US07084170B2
公开(公告)日：2006-08-01
申请号：US10490935
申请日：2002-10-15
Applicant: Cora Sue Grossman , Philip Arthur Hipskind , Ho-Shen Lin , Karen Lynn Lobb , Beatriz Lopez de Uralde Garmendia , Jose Eduardo Lopez , Mary Margaret Mader , Michael Enrico Richett , Chuan Shih , Alfonso De Dios
Inventor： Cora Sue Grossman , Philip Arthur Hipskind , Ho-Shen Lin , Karen Lynn Lobb , Beatriz Lopez de Uralde Garmendia , Jose Eduardo Lopez , Mary Margaret Mader , Michael Enrico Richett , Chuan Shih , Alfonso De Dios
IPC: A61K31/381 , C07D333/34
CPC classification number: C07D277/36 , C07D333/34 , C07D333/38
Abstract: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
Abstract translation: 本发明提供下式的抗肿瘤化合物和抗肿瘤方法。
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公开(公告)号：US06992100B2
公开(公告)日：2006-01-31
申请号：US10450745
申请日：2001-12-06
Applicant: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , John David Jandzinski
Inventor： Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , John David Jandzinski
IPC: A61K31/403 , C07D209/56
CPC classification number: A61K31/403 , A61K31/407 , A61K31/4745
Abstract: A novel class of tetracyclic compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
Abstract translation: 公开了一类新的四环化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎性疾病如脓毒性休克的用途。
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公开(公告)号：US06939890B2
公开(公告)日：2005-09-06
申请号：US10629992
申请日：2003-07-30
Applicant: Richard Waltz Harper , Ho-Shen Lin , Michael Enrico Richett
Inventor： Richard Waltz Harper , Ho-Shen Lin , Michael Enrico Richett
IPC: C07D209/22 , A61K31/404 , C07D207/337
CPC classification number: C07D209/22
Abstract: A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
Abstract translation: 公开了一类新型吲哚以及这些化合物用于抑制脂肪酸介导的释放脂肪酸用于治疗炎性疾病如败血性休克的用途。
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Patent Agency Ranking
公开(公告)号：US06448422B1
公开(公告)日：2002-09-10
申请号：US09609871
申请日：2000-07-03
Applicant: Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Richard Waltz Harper , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett
Inventor： Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Richard Waltz Harper , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett
IPC: C07F902
Abstract: This application relates to a novel compound of formula I, as defined herein, processes and intermediates for its preparation and the use of the compound of formula I as a substrate for a pharmaceutical screen.
Abstract translation: 本申请涉及如本文定义的式I的新化合物，其制备方法和中间体以及式I化合物作为药物筛选的底物的用途。
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公开(公告)号：US06251921B1
公开(公告)日：2001-06-26
申请号：US09312593
申请日：1999-05-14
Applicant: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
Inventor： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC: A61K314436
CPC classification number: C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
Abstract: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
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38.发明授权公开(公告)号：US07595403B2
公开(公告)日：2009-09-29
申请号：US10550006
申请日：2004-03-25
Applicant: Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Ho-Shen Lin , Jose Eduardo Lopez , Marian Kazimierz Mosior , Michael Enrico Richett
Inventor： Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Ho-Shen Lin , Jose Eduardo Lopez , Marian Kazimierz Mosior , Michael Enrico Richett
IPC: A61K31/428 , C07D275/04
CPC classification number: C07D275/04 , C07D417/12
Abstract: A novel class of benzisothiazole-3(2H)-one compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase mediated diseases. (I)
Abstract translation: 公开了一类新的苯并异噻唑-3（2H） - 酮化合物，以及这些化合物用于抑制肝脂肪酶和/或内皮脂肪酶活性用于治疗，改善或预防肝脂肪酶和/或内皮脂肪酶介导的疾病。 （一世）
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![[4-(Benzo[B]thiophen-2-yl) Pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases](/abs-image/US/2009/06/16/US07547691B2/abs.jpg.150x150.jpg)
39.发明授权[4-(Benzo[B]thiophen-2-yl) Pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases 失效[4-（苯并[B]噻吩-2-基）嘧啶-2-基] - 胺衍生物作为治疗癌症和炎性疾病的IKK-β抑制剂公开(公告)号：US07547691B2
公开(公告)日：2009-06-16
申请号：US12093024
申请日：2006-11-15
Applicant: Karl Robert Dahnke , Ho-Shen Lin , Michael Enrico Richett , Chuan Shih , Q May Wang , Bo Zhang
Inventor： Karl Robert Dahnke , Ho-Shen Lin , Michael Enrico Richett , Chuan Shih , Q May Wang , Bo Zhang
IPC: C07D409/04 , A61K31/506
CPC classification number: C07D409/04
Abstract: The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.
Abstract translation: 本发明提供式I化合物：可用于治疗癌症和炎性疾病。
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40.发明授权7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B) 失效作为akt（蛋白激酶B）的抑制剂的7-苯基 - 异喹啉-5-磺酰基氨基衍生物公开(公告)号：US07449477B2
公开(公告)日：2008-11-11
申请号：US10595798
申请日：2004-11-22
Applicant: David Anthony Barda , Kenneth James Henry, Jr. , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Enrico Richett
Inventor： David Anthony Barda , Kenneth James Henry, Jr. , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Enrico Richett
IPC: C07D217/22 , C07D401/12 , A61K31/4725 , A61K31/472
CPC classification number: C04B35/632 , C07D217/02 , C07D217/22 , C07D401/12
Abstract: The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
Abstract translation: 本发明涉及作为AKT活性抑制剂的式（I）化合物，其可用于治疗易感性肿瘤和病毒感染。
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