-
公开(公告)号：US06251921B1
公开(公告)日：2001-06-26
申请号：US09312593
申请日：1999-05-14
申请人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号： A61K314436
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要： This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
-
公开(公告)号：US6025382A
公开(公告)日：2000-02-15
申请号：US846647
申请日：1997-04-30
申请人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号： C07D295/08 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4436 , A61K31/4439 , A61K31/4453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P7/02 , C07D333/56 , C07D333/58 , C07D333/62 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/12 , C07D413/06 , C07D521/00 , A61K31/40 , A61K31/38 , C07D409/14
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要： This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
摘要翻译： 本申请涉及作为本文定义的式I二胺的凝血酶抑制剂，凝血抑制剂和血栓栓塞障碍剂的用途。 它还提供式I的新型化合物，其制备方法和中间体，以及包含式I化合物的药物制剂。
-
公开(公告)号：US06265416B1
公开(公告)日：2001-07-24
申请号：US09429424
申请日：1999-10-28
申请人： Jolie Anne Bastian , Matthew Joseph Fisher , Richard Waltz Harper , Ho-Shen Lin , Jefferson Ray McCowan , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Michael Robert Wiley , Minsheng Zhang
发明人： Jolie Anne Bastian , Matthew Joseph Fisher , Richard Waltz Harper , Ho-Shen Lin , Jefferson Ray McCowan , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Michael Robert Wiley , Minsheng Zhang
IPC分类号： A61K31535
CPC分类号： C07D471/04
摘要： This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.
-
公开(公告)号：US06359136B1
公开(公告)日：2002-03-19
申请号：US09716605
申请日：2000-11-20
申请人： Jolie Ann Bastian , Matthew Joseph Fisher , Richard Waltz Harper , Ho-Shen Lin , Jefferson Ray McCowan , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Michael Robert Wiley , Minsheng Zhang
发明人： Jolie Ann Bastian , Matthew Joseph Fisher , Richard Waltz Harper , Ho-Shen Lin , Jefferson Ray McCowan , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Michael Robert Wiley , Minsheng Zhang
IPC分类号： C07D47104
CPC分类号： C07D471/04
摘要： This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.
摘要翻译： 本申请涉及本文定义的式I（及其药学上可接受的盐）的新型化合物，其制备方法和中间体，包含式I的新型化合物的药物制剂以及式I化合物作为凝血酶抑制剂的用途 。
-
公开(公告)号：US06620837B1
公开(公告)日：2003-09-16
申请号：US10111508
申请日：2002-04-23
IPC分类号： A61K3140
CPC分类号： C07D409/10 , C07D333/16 , C07D333/24 , C07D409/12
摘要： This application relates to novel compounds of formula (I) (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of defined compounds of formula (I) as thrombin inhibitors.
摘要翻译： 本申请涉及本文定义的式（I）（及其药学上可接受的盐），其制备方法和中间体的新型化合物，其包含式（I）的新化合物的药物制剂，以及定义的式 （I）作为凝血酶抑制剂。
-
公开(公告)号：US06391901B1
公开(公告)日：2002-05-21
申请号：US09423148
申请日：2000-01-21
申请人： Nickolay Y Chirgadze , Michael L Denney , Matthew J Fisher , Robert J Foglesong , Richard W Harper , Mary G Johnson , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Shawn C Miller , Alan D Palkowitz , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Minsheng Zhang
发明人： Nickolay Y Chirgadze , Michael L Denney , Matthew J Fisher , Robert J Foglesong , Richard W Harper , Mary G Johnson , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Shawn C Miller , Alan D Palkowitz , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Minsheng Zhang
IPC分类号： A61K314025
CPC分类号： C07D333/58 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D333/56 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of defined compounds of formula I as thrombin inhibitors.
摘要翻译： 本申请涉及本文定义的式I（及其药学上可接受的盐）的新型化合物，其制备方法和中间体，包含式I的新化合物的药物制剂，以及定义的式I化合物作为凝血酶抑制剂的用途 。
-
公开(公告)号：US06284756B1
公开(公告)日：2001-09-04
申请号：US09423166
申请日：2000-01-21
申请人： Nickolay Y Chirgadze , Richard W Harper , Todd J Kohn , Ho-Shen Lin , Jefferson R McCowan , Alan D Palkowitz , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Michael R Wiley , Minsheng Zhang
发明人： Nickolay Y Chirgadze , Richard W Harper , Todd J Kohn , Ho-Shen Lin , Jefferson R McCowan , Alan D Palkowitz , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Michael R Wiley , Minsheng Zhang
IPC分类号： A61K314025
CPC分类号： C07D333/58 , C07D333/56 , C07D409/10 , C07D409/12
摘要： This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.
摘要翻译： 本申请涉及本文定义的式I（及其药学上可接受的盐）的新型化合物，其制备方法和中间体，包含式I的新型化合物的药物制剂以及式I化合物作为凝血酶抑制剂的用途 。
-
公开(公告)号：US06271227B1
公开(公告)日：2001-08-07
申请号：US09423124
申请日：2000-01-24
申请人： Nickolay Y Chirgadze , Matthew J Fisher , Richard W Harper , Ho-Shen Lin , Jefferson R McCowan , Alan D Palkowitz , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Minsheng Zhang
发明人： Nickolay Y Chirgadze , Matthew J Fisher , Richard W Harper , Ho-Shen Lin , Jefferson R McCowan , Alan D Palkowitz , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Minsheng Zhang
IPC分类号： A61K215377
CPC分类号： C07D409/12 , C07D333/56 , C07D333/58 , C07D409/10
摘要： This application relates to novel compounds of formula (I) (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
摘要翻译： 本申请涉及本文定义的式（I）（及其药学上可接受的盐），其制备方法和中间体的新型化合物，其包含式（I）的新化合物的药物制剂，以及式 （I）作为凝血酶抑制剂。
-
公开(公告)号：US06541499B1
公开(公告)日：2003-04-01
申请号：US09423147
申请日：2000-01-21
申请人： Jolie A Bastian , Nickolay Y Chirgadze , Michael L Denney , Matthew J Fisher , Robert J Foglesong , Richard W Harper , Mary G Johnson , Valentine J Klimkowski , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Shawn C Miller , Jeffrey T Mullaney , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Jennifer M Tinsley , Michael R Wiley , Minsheng Zhang
发明人： Jolie A Bastian , Nickolay Y Chirgadze , Michael L Denney , Matthew J Fisher , Robert J Foglesong , Richard W Harper , Mary G Johnson , Valentine J Klimkowski , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Shawn C Miller , Jeffrey T Mullaney , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Jennifer M Tinsley , Michael R Wiley , Minsheng Zhang
IPC分类号： A61K314196
CPC分类号： C07D231/12 , A61K31/4184 , A61K31/4196 , A61K31/497 , C07D233/56 , C07D235/18 , C07D249/08 , C07D403/12
摘要： The invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
摘要翻译： 本发明涉及式（I）的新化合物及其药学上可接受的盐，如本文所定义，其制备方法和中间体，包含新型式（I）化合物的药物制剂，以及式（I）化合物 I）作为凝血酶抑制剂。
-
公开(公告)号：US06350774B1
公开(公告)日：2002-02-26
申请号：US09423165
申请日：2000-01-24
申请人： Nicholas J Bach , Jolie A. Bastian , Nickolay Y Chirgadze , Michael L Denney , Robert J. Foglesong , Richard W Harper , Mary G Johnson , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Alan D Palkowitz , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Minsheng Zhang
发明人： Nicholas J Bach , Jolie A. Bastian , Nickolay Y Chirgadze , Michael L Denney , Robert J. Foglesong , Richard W Harper , Mary G Johnson , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Alan D Palkowitz , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Minsheng Zhang
IPC分类号： A61K3138
CPC分类号： C07D333/58 , C07D333/56 , C07D333/60 , C07D409/10 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This application relates to novel compounds of formula (I) (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
摘要翻译： 本申请涉及本文定义的式（I）（及其药学上可接受的盐），其制备方法和中间体的新型化合物，其包含式（I）的新化合物的药物制剂，以及式 （I）作为凝血酶抑制剂。
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.088 秒)
