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    Preparation of biodegradable, biocompatible microparticles containing a biologically active agent
    31.
    发明授权
    Preparation of biodegradable, biocompatible microparticles containing a biologically active agent 有权
    制备含有生物活性剂的可生物降解的生物相容性微粒

    公开(公告)号：US06290983B1

    公开(公告)日：2001-09-18

    申请号：US09578717

    申请日：2000-05-26

    Applicant: Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis

    Inventor： Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis

    IPC: A61F200

    CPC classification number: B01J13/04 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/519 ,  Y10T428/2985

    Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.

    Abstract translation: 一种制备可生物降解的生物相容性微粒的方法。 制备包含可生物降解的生物相容性聚合物，活性剂和溶剂的第一相。 准备第二阶段 第一和第二相组合形成乳液，其中第一相是不连续的，第二相是连续的。 不连续的第一相与连续的第二相分离。 不连续第一相中溶剂的残留量减少到小于约2重量％。

    Methods and systems for polymer precipitation and generation of particles
    32.
    发明授权
    Methods and systems for polymer precipitation and generation of particles 有权

    公开(公告)号：US09598503B2

    公开(公告)日：2017-03-21

    申请号：US13864429

    申请日：2013-04-17

    Applicant: J. Michael Ramstack ,  Thomas C. Crawford

    Inventor： J. Michael Ramstack ,  Thomas C. Crawford

    IPC: C08B37/16

    CPC classification number: C08B37/0012

    Abstract: Processes for precipitating a polymer from a polymer-containing fluid are disclosed, which include providing a vessel housing a medium that provides one or more precipitation surfaces. A polymer-containing fluid, e.g., a polymer solution, dispersion or mixed solution/dispersion, and an anti-solvent can be introduced into the vessel so as to cause precipitation of at least a portion of the polymer on at least one of the precipitation surfaces. In some embodiments, the polymer contains one or more cyclic oligosaccharide moieties, such as one or more cyclodextrin moieties (e.g., α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin). The polymer can be any of a linear or branched polymer. The polymer can be any of polycation, a polyanion, or a non-ionic polymer. Also disclosed herein are precipitation surfaces with polymer precipitated thereon.

    METHOD FOR FABRICATING NANOPARTICLES
    35.
    发明申请
    METHOD FOR FABRICATING NANOPARTICLES 有权
    制备纳米颗粒的方法

    公开(公告)号：US20120196990A1

    公开(公告)日：2012-08-02

    申请号：US13357977

    申请日：2012-01-25

    Applicant: J. Michael Ramstack ,  John Podobinski

    Inventor： J. Michael Ramstack ,  John Podobinski

    IPC: B01J19/00 ,  B01D61/00 ,  C08G63/06 ,  C08G63/91 ,  B82Y5/00

    CPC classification number: B01D35/30 ,  B01D61/027 ,  B01D2239/0258 ,  B01D2315/10 ,  B01D2315/16 ,  B01J14/00 ,  B01J19/00 ,  B01J2219/00006 ,  B82Y5/00 ,  B82Y40/00 ,  C08J3/14 ,  C08J2367/04

    Abstract: Systems and methods are provided for filtering a fluid containing nanoparticles. The systems and methods generally include introducing a stream of the nanoparticle-containing fluid into a holding vessel, and extracting at least a part of a nanoparticle-containing fluid accumulated in the holding vessel. The extracted nanoparticle-containing fluid is passed through a filtration module to separate a nanoparticle-containing retentate from a permeate, and the retentate is returned to the vessel. The filtration cycle can be repeated until a desired concentration of the nanoparticles is achieved in the holding vessel. In many embodiments, the generation of the nanoparticle-containing fluid and its filtration are performed concurrently.

    Abstract translation: 提供了用于过滤含有纳米颗粒的流体的系统和方法。 系统和方法通常包括将含纳米颗粒的流体流引入保持容器中，以及提取在储存容器中积聚的含纳米颗粒的流体的至少一部分。 将提取的含纳米颗粒的流体通过过滤模块以从渗透物中分离含纳米颗粒的渗余物，并将滞留物返回到容器中。 可以重复该过滤循环，直到在保持容器中达到所需的纳米颗粒浓度。 在许多实施方案中，同时进行含纳米颗粒的流体的产生及其过滤。

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