公开(公告)号：US20090263398A1

公开(公告)日：2009-10-22

申请号：US12373713

申请日：2007-07-13

Applicant: John Francis Lyons ,  Matthew Simon Squires ,  Neil Thomas Thompson ,  Neil James Gallagher ,  Jayne Elizabeth Curry

Inventor： John Francis Lyons ,  Matthew Simon Squires ,  Neil Thomas Thompson ,  Neil James Gallagher ,  Jayne Elizabeth Curry

IPC: A61K31/415 ,  A61K31/422 ,  A61K31/4178 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/454 ,  A61K31/506 ,  A61K31/541 ,  A61K31/439 ,  A61P35/00 ,  A61K39/395

CPC classification number: A61K31/4453 ,  A61K31/415 ,  A61K2300/00

Abstract: The invention provides a combination comprising an ancillary compound and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C═O, NR9(C═O) or 0(C═O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy; or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy; R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy.

Abstract translation: 本发明提供包含辅助化合物和具有式（O）的化合物的组合：或其盐或互变异构体或N-氧化物或溶剂合物; 其中X为基团R 1 -A-NR 4 - 或5或6元碳环或杂环; A为键，SO 2，C-O，NR 9（C-O）或O（C-O），其中R 9为氢或任选被羟基或C 1-4烷氧基取代的C 1-4烃基; Y是长度为1,2或3个碳原子的键或亚烷基链; R1是氢; 具有3至12个环成员的碳环或杂环基; 或任选被一个或多个选自卤素，羟基，C 1-4烃氧基，氨基，一或二-C 1-4烃基氨基的取代基取代的C 1-8烃基，以及具有3-12个环成员的碳环或杂环基， 并且其中所述烃基的1或2个碳原子可以任选地被选自O，S，NH，SO，SO 2的原子或基团取代; R2是氢; 卤素; C 1-4烷氧基; 或任选被卤素，羟基或C 1-4烷氧基取代的C 1-4烃基; R 3选自具有3至12个环成员的氢和碳环和杂环基; R4是氢或任选被卤素，羟基或C 1-4烷氧基取代的C 1-4烃基。

公开(公告)号：US20080297987A1

公开(公告)日：2008-12-04

申请号：US11779827

申请日：2007-07-18

Applicant: Mark Robert Hawley ,  Jeremy James Gallagher ,  Walter Dean Takisaki ,  James Patrick Jenkins

Inventor： Mark Robert Hawley ,  Jeremy James Gallagher ,  Walter Dean Takisaki ,  James Patrick Jenkins

IPC: H05K5/02

CPC classification number: H05K7/186 ,  H04Q1/021 ,  H04Q1/062 ,  H04Q1/064

Abstract: Structured cabling solutions may include techniques and systems usable to route, organize, and otherwise manager wires, optical fibers, and other cables. Structured cabling solutions may include one or more chassis coupled to and movable relative to a frame to provide access to signal connectors on the chassis. Structured cabling solutions may also include labeling schemes that identify patch connectors that correspond to outlets in a structured cabling installation.

Abstract translation: 结构化布线解决方案可以包括可用于路由，组织和以其他方式管理电线，光纤和其他电缆的技术和系统。 结构化布线解决方案可以包括耦合到框架并相对于框架可移动的一个或多个底板，以提供对底盘上的信号连接器的访问。 结构化布线解决方案还可以包括识别对应于结构化布线设备中的插座的贴片连接器的标签方案。

公开(公告)号：US20070233930A1

公开(公告)日：2007-10-04

申请号：US11375493

申请日：2006-03-14

Applicant: James Gallagher ,  David Galvin ,  Binh Hua ,  Sivarama Kodukula

Inventor： James Gallagher ,  David Galvin ,  Binh Hua ,  Sivarama Kodukula

IPC: G06F13/40

CPC classification number: G06F13/4018

Abstract: A peripheral component Interconnect (PCI) switch that has at least one control logic device that is capable of changing, on-demand, widths of dedicated buses is provided. The buses are PCI Express buses and thus, are composed of lanes. The control logic device is a lane enable register (LER). Each location in the LER corresponds to a lane of a dedicated bus and is used to enable or disable the corresponding lane. Consequently, widths of dedicated buses are changed by using the switch of the invention to add or subtract one or more lanes from the buses.

Abstract translation: 提供了具有能够改变专用总线宽度的至少一个控制逻辑器件的外围部件互连（PCI）交换机。 公共汽车是PCI Express巴士，因此由车道组成。 控制逻辑器件是通道使能寄存器（LER）。 LER中的每个位置对应于专用总线的通道，并用于启用或禁用相应的通道。 因此，通过使用本发明的开关来改变专用总线的宽度以从总线中增加或减少一个或多个车道。

公开(公告)号：US20060077950A1

公开(公告)日：2006-04-13

申请号：US10960586

申请日：2004-10-07

Applicant: James Gallagher ,  Binh Hua ,  Hong Hua ,  Sivarama Kodukula

Inventor： James Gallagher ,  Binh Hua ,  Hong Hua ,  Sivarama Kodukula

IPC: H04L12/28

CPC classification number: H04L47/10 ,  H04L47/283

Abstract: Method, system and computer program product for transferring data in a data processing system network. A method for transferring data in a data processing system network according to the invention includes determining an adapter among a plurality of adapters that has the lowest transmit latency, and assigning data to be transferred to the adapter determined to have the lowest transmit latency. The data to be transferred is then transferred by the assigned adapter. The present invention utilizes network adapters to transfer data in a more efficient manner.

Abstract translation: 用于在数据处理系统网络中传输数据的方法，系统和计算机程序产品。 根据本发明的用于在数据处理系统网络中传送数据的方法包括：确定具有最低发射延迟的多个适配器之间的适配器，以及将要传送到适配器的数据分配给确定具有最低发射延迟的适配器。 要转让的数据然后由分配的适配器传输。 本发明利用网络适配器以更有效的方式传输数据。

公开(公告)号：US20060068384A1

公开(公告)日：2006-03-30

申请号：US10497778

申请日：2002-12-04

Applicant: David McCreavy ,  William Fraser ,  James Gallagher

Inventor： David McCreavy ,  William Fraser ,  James Gallagher

IPC: C12Q1/68

CPC classification number: C12Q1/6804

Abstract: A method to detect biological molecules in a sample which is an immuno polymerase chain reaction assay which comprises the detection of a complex which includes a ligand: nucleic acid conjugate bound to at least one biological molecule. The complex is detected by the addition of a second nucleic acid molecule which is adapted to anneal to the nucleic acid of the conjugate.

Abstract translation: 一种检测样品中的生物分子的方法，其是免疫聚合酶链反应测定法，其包括检测包含与至少一个生物分子结合的配体：核酸缀合物的复合物。 通过添加适于与缀合物的核酸退火的第二核酸分子来检测复合物。

公开(公告)号：US20060011412A1

公开(公告)日：2006-01-19

申请号：US11179327

申请日：2005-07-12

Applicant: James Gallagher ,  Michael Saunders

Inventor： James Gallagher ,  Michael Saunders

IPC: F01N1/12

CPC classification number: F16L55/0331

Abstract: A method is employed to attenuate ultrasonic noise propagating in a flow stream of a fluid flow system. In particular, the method attenuates the noise propagating between a noise source and a reference point in the flow stream (wherein the reference point and the noise source are positioned in the flow stream in direct acoustic line of sight relation). The method includes positioning an absorbent element in the flow stream between the noise source and the reference point. Then, the ultrasonic noise is directed past vicinity of the absorbent element such that indirect ultrasonic noise is absorbed by the absorbent element. Preferably, the method also includes deflecting the ultrasonic noise to convert direct noise to indirect noise prior to directing the ultrasonic noise past the vicinity of the absorbent material in the flow stream. Such a method may be employed to attenuate ultrasonic noise by up to about 20 dB to 45 dB.

Abstract translation: 采用一种方法来衰减在流体流动系统的流动流中传播的超声波噪声。 特别地，该方法衰减在流动流中的噪声源和参考点之间传播的噪声（其中参考点和噪声源位于直接声学视线关系中的流动流中）。 该方法包括将吸收元件定位在噪声源和参考点之间的流动流中。 然后，超声波噪声被引导到吸收元件附近，使得间接的超声波噪声被吸收元件吸收。 优选地，该方法还包括偏转超声波噪声，以在将超声波噪声引导通过吸收材料附近的流动流之前将直接噪声转换为间接噪声。 可以采用这种方法来将超声波噪声衰减高达约20dB至45dB。

公开(公告)号：US20050204080A1

公开(公告)日：2005-09-15

申请号：US10798934

申请日：2004-03-11

Applicant: James Gallagher ,  Ron Gonzalez ,  Binh Hua ,  Sivarama Kodukula

Inventor： James Gallagher ,  Ron Gonzalez ,  Binh Hua ,  Sivarama Kodukula

IPC: G06F13/10

CPC classification number: G06F9/5016 ,  G06F2209/5011

Abstract: A method, system, and computer program product in a data processing system are disclosed for dynamically selecting software buffers for aggregation in order to optimize system performance. Data to be transferred to a device is received. The data is stored in a chain of software buffers. Current characteristics of the system are determined. Software buffers to be combined are then dynamically selected. This selection is made according to the characteristics of the system in order to maximize performance of the system.

Abstract translation: 公开了一种数据处理系统中的方法，系统和计算机程序产品，用于动态选择用于聚合的软件缓冲器，以优化系统性能。 接收要传输到设备的数据。 数据存储在软件缓冲区链中。 确定系统的当前特性。 然后动态选择要组合的软件缓冲区。 该选择是根据系统的特性进行的，以便最大限度地提高系统性能。

公开(公告)号：US06447661B1

公开(公告)日：2002-09-10

申请号：US09416288

申请日：1999-10-12

Applicant: Andrea W. Chow ,  Robert S. Dubrow ,  J. Wallace Parce ,  Steven A. Sundberg ,  Jeffrey A. Wolk ,  Ring-Ling Chien ,  Steven James Gallagher ,  Michael R. Knapp ,  Anne R. Kopf-Sill ,  Tammy Burd Mehta

Inventor： Andrea W. Chow ,  Robert S. Dubrow ,  J. Wallace Parce ,  Steven A. Sundberg ,  Jeffrey A. Wolk ,  Ring-Ling Chien ,  Steven James Gallagher ,  Michael R. Knapp ,  Anne R. Kopf-Sill ,  Tammy Burd Mehta

IPC: G01N2726

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  G01N2035/00237 ,  G01N2035/1062 ,  Y10S366/02 ,  Y10T436/2575

Abstract: Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.

Abstract translation: 提供了方法，装置和系统，用于将大量不同的材料快速，有效和可再现地引入微流体分析装置。 特别地，改进的集成移液器芯片配置，例如 描述了能够对需要分析的极少量材料进行取样，将材料输送到微流体分析通道网络中并对材料进行所需分析的能力。

公开(公告)号：US08532197B2

公开(公告)日：2013-09-10

申请号：US12706491

申请日：2010-02-16

Applicant: Jonathan Joseph Lareau ,  Andrew James Gallagher

Inventor： Jonathan Joseph Lareau ,  Andrew James Gallagher

IPC: H04N7/12

CPC classification number: H04N5/2357

Abstract: A method for detecting a temporally oscillating source in digital video signals includes: using an imaging device to capture a sequence of input images of a scene; generating digital video signals from the sequence of input images; and processing the digital video signals using a recursive Infinite Impulse Response (IIR) filter technique based on a differentiated version of Goertzel's Algorithm to detect a temporally oscillating source in the digital video signals. In various embodiments, the method also includes generating a visual display of the scene including one or more graphical elements at least one of which pertains to a detected temporally oscillating source.

Abstract translation: 一种用于检测数字视频信号中的时间振荡源的方法包括：使用成像装置捕获场景的输入图像序列; 从输入图像序列生成数字视频信号; 以及使用基于Goertzel算法的差分版本的递归无限脉冲响应（IIR）滤波技术来处理数字视频信号，以检测数字视频信号中的时间振荡源。 在各种实施例中，该方法还包括生成场景的视觉显示，包括一个或多个图形元素，其中至少一个与检测到的时间振荡源相关。

公开(公告)号：US08435970B2

公开(公告)日：2013-05-07

申请号：US12306479

申请日：2007-06-29

Applicant: Jayne Elizabeth Curry ,  Neil James Gallagher ,  John Francis Lyons ,  Neil Thomas Thompson

Inventor： Jayne Elizabeth Curry ,  Neil James Gallagher ,  John Francis Lyons ,  Neil Thomas Thompson

IPC: A61K31/56 ,  A61K31/535 ,  A61K31/52 ,  A61K31/44 ,  A61K31/445

CPC classification number: A61K45/06 ,  A61K31/337 ,  A61K31/475 ,  A61K31/5377 ,  A61K31/7072 ,  A61K33/24 ,  A61K2300/00

Abstract: The invention provides combinations of an ancillary compound and a compound which is a salt of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea selected from the lactate and citrate salts and mixtures thereof. Also provided are crystalline forms of the salts, methods for making the salts and their uses in treating cancers. The invention further provides combinations of an ancillary compound and a compound of the formula (I) as defined in PCT/GB2004/002824 (WO 2005/002552) or a compound of the formula (I′) or a salt, solvate, tautomer or N-oxide thereof, wherein R1, E, A and M are as defined in the claims.

Abstract translation: 本发明提供了辅助化合物和化合物的组合，其是1-环丙基-3- [3-（5-吗啉-4-基甲基-1H-苯并咪唑-2-基）-1H-吡唑-4-基 ] - 选自乳酸盐和柠檬酸盐及其混合物。 还提供盐的结晶形式，制备盐的方法及其在治疗癌症中的用途。 本发明还提供了辅助化合物和如PCT / GB2004 / 002824（WO 2005/002552）中定义的式（I）化合物或式（I'）化合物或其盐，溶剂合物，互变异构体或 其中R1，E，A和M如权利要求中所定义。