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    High-throughput analytical microfluidic systems and methods of making same
    1.
    发明授权
    High-throughput analytical microfluidic systems and methods of making same 有权
    高通量分析微流体系统及其制备方法

    公开(公告)号：US06773567B1

    公开(公告)日：2004-08-10

    申请号：US09662409

    申请日：2000-09-14

    Applicant: Jeffrey A. Wolk

    Inventor： Jeffrey A. Wolk

    IPC: G01N2726

    CPC classification number: B01L3/502707 ,  B01F13/0076 ,  B01F13/0077 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/12 ,  B01L2300/0838 ,  B01L2300/16 ,  B01L2400/0415 ,  G01N27/44704 ,  Y10S366/02 ,  Y10T29/49117 ,  Y10T29/49787 ,  Y10T29/49798

    Abstract: A method for fabricating a capillary element for electrokinetic transport of materials. The method comprises providing a first capillary element which has a first capillary channel disposed through its length. The capillary channel comprises first and second ends and an outer surface. A continuous layer of an electrically conductive material is applied along a length of the outer surface such that the continuous layer of electrically conductive material extends along the outer surface to a point proximal to, but not up to at least one of the first and second ends. The capillary element is then segmented into at least first and second separate capillary element portions at an intermediate point of the capillary element and the continuous layer.

    Abstract translation: 一种用于制造用于电动运输材料的毛细管元件的方法。 该方法包括提供第一毛细管元件，其具有穿过其长度设置的第一毛细通道。 毛细通道包括第一和第二端和外表面。 沿着外表面的​​长度施加连续的导电材料层，使得连续的导电材料层沿着外表面延伸到靠近第一和第二端的至少一个点 。 毛细管元件然后在毛细管元件和连续层的中间点处分成至少第一和第二分离的毛细管元件部分。

    Alignment of multicomponent microfabricated structures
    3.
    发明授权
    Alignment of multicomponent microfabricated structures 有权
    多组分微制造结构的对齐

    公开(公告)号：US06322683B1

    公开(公告)日：2001-11-27

    申请号：US09291808

    申请日：1999-04-14

    Applicant: Jeffrey A. Wolk ,  Richard J. McReynolds ,  J. Wallace Parce

    Inventor： Jeffrey A. Wolk ,  Richard J. McReynolds ,  J. Wallace Parce

    IPC: G01N2726

    CPC classification number: B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0487

    Abstract: Microfluidic devices are fabricated by fabricating structures that are used to align elements that are to be attached to the devices or tools that are to be used in further fabrication steps on those devices. Elements to be attached include additional substrate layers, external sampling elements, e.g. capillaries, and the like. Preferred alignment structures include wells over which reservoirs are positioned, notches for use with alignment keys to align substrate layers or for receiving additional structural elements, and targets or guide holes for receiving tooling in further fabrication steps.

    Abstract translation: 微流体装置通过制造用于对准要附接到在这些装置上的进一步制造步骤中使用的装置或工具的元件的结构来制造。 待连接的元件包括附加的基底层，外部取样元件， 毛细血管等。 优选的对准结构包括在其上定位储存器的孔，用于对齐键以对准衬底层或用于接收附加结构元件的凹口，以及用于在进一步制造步骤中接收工具的靶或引导孔。

    Method of making a capillary for electrokinetic transport of materials
    4.
    发明授权
    Method of making a capillary for electrokinetic transport of materials 失效
    制造用于电动运输材料的毛细管的方法

    公开(公告)号：US06148508A

    公开(公告)日：2000-11-21

    申请号：US267428

    申请日：1999-03-12

    Applicant: Jeffrey A. Wolk

    Inventor： Jeffrey A. Wolk

    IPC: B01F13/00 ,  B01L3/00 ,  G01N27/447 ,  H01R43/00

    CPC classification number: B01L3/502707 ,  B01F13/0076 ,  B01F13/0077 ,  G01N27/44704 ,  B01L2200/027 ,  B01L2200/12 ,  B01L2300/0838 ,  B01L2300/16 ,  B01L2400/0415 ,  B01L3/50273 ,  Y10S366/02 ,  Y10T29/49117 ,  Y10T29/49787 ,  Y10T29/49798

    Abstract: A method for fabricating a capillary element for electrokinetic transport of materials. The method comprises providing a first capillary element which has a first capillary channel disposed through its length. The capillary channel comprises first and second ends and an outer surface. A continuous layer of an electrically conductive material is applied along a length of the outer surface such that the continuous layer of electrically conductive material extends along the outer surface to a point proximal to, but not up to at least one of the first and second ends. The capillary element is then segmented into at least first and second separate capillary element portions at an intermediate point of the capillary element and the continuous layer.

    Abstract translation: 一种用于制造用于电动运输材料的毛细管元件的方法。 该方法包括提供第一毛细管元件，其具有穿过其长度设置的第一毛细通道。 毛细通道包括第一和第二端和外表面。 沿着外表面的​​长度施加连续的导电材料层，使得连续的导电材料层沿着外表面延伸到靠近第一和第二端的至少一个点 。 毛细管元件然后在毛细管元件和连续层的中间点处分成至少第一和第二分离的毛细管元件部分。

    High throughput microfluidic systems and methods
    6.
    发明授权
    High throughput microfluidic systems and methods 有权
    高通量微流体系统和方法

    公开(公告)号：US6132685A

    公开(公告)日：2000-10-17

    申请号：US132096

    申请日：1998-08-10

    Applicant: Joseph E. Kercso ,  Steven A. Sundberg ,  Jeffrey A. Wolk ,  Andrew W. Toth ,  Calvin Y. H. Chow ,  J. Wallace Parce

    Inventor： Joseph E. Kercso ,  Steven A. Sundberg ,  Jeffrey A. Wolk ,  Andrew W. Toth ,  Calvin Y. H. Chow ,  J. Wallace Parce

    IPC: G01N35/00 ,  G01N35/02

    CPC classification number: G01N35/028 ,  G01N2035/00148 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/119163 ,  Y10T436/25625 ,  Y10T436/2575

    Abstract: The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multiwell microtiter plates or other array structures. The multiwell plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multiwell plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.

    Abstract translation: 本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统，装置和方法。 多孔板沿传送系统行进到具有微流体装置的测试台。 在试验台，每个板从输送机上取出，多孔板的孔依次与微流体装置的输入端对准。 在每个样品的至少一部分已经被输入到微流体通道系统中之后，板返回到输送系统。 可以沿输送机系统布置前后测试站，并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络 芯片。 具有铰接盖的蛤壳结构可以可释放地支撑芯片，同时提供和/或容纳微流体装置和周围系统之间的电，光学，结构和其它界面连接。

    High throughput microfluidic systems and methods
    7.
    发明授权
    High throughput microfluidic systems and methods 有权
    高通量微流体系统和方法

    公开(公告)号：US06495369B1

    公开(公告)日：2002-12-17

    申请号：US09545241

    申请日：2000-04-07

    Applicant: Joseph E. Kercso ,  Steven A. Sundberg ,  Jeffrey A. Wolk ,  Andrew W. Toth ,  Calvin Y. H. Chow ,  J. Wallace Parce

    Inventor： Joseph E. Kercso ,  Steven A. Sundberg ,  Jeffrey A. Wolk ,  Andrew W. Toth ,  Calvin Y. H. Chow ,  J. Wallace Parce

    IPC: G01N3502

    CPC classification number: G01N35/028 ,  G01N2035/00148 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/119163 ,  Y10T436/25625 ,  Y10T436/2575

    Abstract: The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multi-well microtiter plates or other array structures. The multi-well plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multi-well plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.

    Abstract translation: 本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统，装置和方法。 多孔板沿着输送系统行进到具有微流体装置的测试台。 在测试台处，每个板从输送机中取出，多孔板的孔依次与微流体装置的输入端对准。 在每个样品的至少一部分已经被输入到微流体通道系统中之后，板返回到输送系统。 可以沿输送机系统布置前后测试站，并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络 芯片。 具有铰接盖的蛤壳结构可以可释放地支撑芯片，同时提供和/或容纳微流体装置和周围系统之间的电，光学，结构和其它界面连接。

    Compact optical detection system for a microfluidic device
    10.
    发明授权
    Compact optical detection system for a microfluidic device 有权
    用于微流体装置的紧凑型光学检测系统

    公开(公告)号：US07518726B2

    公开(公告)日：2009-04-14

    申请号：US11404043

    申请日：2006-04-12

    Applicant: Aaron Rulison ,  Jeffrey A. Wolk ,  Ernest C.W. Lee ,  Michael Slater ,  Morten J. Jensen

    Inventor： Aaron Rulison ,  Jeffrey A. Wolk ,  Ernest C.W. Lee ,  Michael Slater ,  Morten J. Jensen

    IPC: G01B11/00

    CPC classification number: G01B11/002 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2300/0816 ,  G01N21/645 ,  G01N2021/0162 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6478 ,  G01N2201/0627 ,  G02B21/16

    Abstract: An optical detection system for a microfluidic device and a dry-focus microfluidic device compatible with the compact optical detection system are described. The system includes an LED; means for collimating light emitted by the LED; an aspherical, fused-silica objective lens; means for directing the collimated light through the objective onto a microfluidic device; and means for detecting a fluorescent signal emitted from the microfluidic device. The working distance between the objective and the device allows light from an external LED or laser to be brought in along a diagonal path to illuminate the microfluidic device. The dry-focus microfluidic device includes multiple channels and multiple closed optical alignment marks having curved walls. At least one of the channels is positioned between at least two of the marks. The marks are illuminated for alignment and focusing purposes by light brought in on a diagonal path from an external white LED.

    Abstract translation: 描述了用于微流体装置的光学检测系统和与紧凑型光学检测系统兼容的干焦微流体装置。 该系统包括一个LED; 用于准直LED发出的光的装置; 非球面，熔融二氧化硅物镜; 用于将准直光通过物镜引导到微流体装置上的装置; 以及用于检测从微流体装置发射的荧光信号的装置。 物镜与设备之间的工作距离允许来自外部LED或激光器的光沿着对角线路进入以照亮微流体装置。 干焦微流体装置包括具有弯曲壁的多个通道和多个封闭的光学对准标记。 至少一个通道位于至少两个标记之间。 通过从外部白色LED的对角线路上引入的光照亮标记以进行对准和聚焦。

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