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公开(公告)号：US08883790B2
公开(公告)日：2014-11-11
申请号：US12445136
申请日：2007-10-12
Applicant: Neil James Gallagher , John Francis Lyons , Neil Thomas Thompson , Stephen Murray Yule , Christopher William Murray
Inventor： Neil James Gallagher , John Francis Lyons , Neil Thomas Thompson , Stephen Murray Yule , Christopher William Murray
IPC: A61K31/497 , A61K31/535 , C07D401/14 , A61K31/403 , A61K31/438 , A61K31/439 , C07D209/08 , C07D209/44 , C07D215/08 , C07D401/04 , C07D471/04 , C07D471/10 , C07D491/08 , C07D491/10 , A61K31/496 , A61K31/5375
CPC classification number: C07D401/14 , A61K31/403 , A61K31/438 , A61K31/439 , A61K31/496 , A61K31/5375 , C07D209/08 , C07D209/44 , C07D215/08 , C07D401/04 , C07D471/04 , C07D471/10 , C07D491/08 , C07D491/10 , A61K2300/00
Abstract: The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The combinations have activity as Hsp90 and/or glycogen synthase kinase-3 and/or cyclin dependent kinase and/or aurora kinase inhibitors.
Abstract translation: 本发明提供包含（或基本上由）一种或多种辅助化合物和式（I）化合物或其盐，互变异构体，溶剂合物和N-氧化物的组合; 其中R1是羟基或氢; R2是羟基; 甲氧基或氢; 条件是R 1和R 2中的至少一个是羟基; R3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5烃氧基; R4选自氢; 其中n为0或1，R7为任选取代的无环C 1-5烃基或具有3至7个环成员的单环碳环或杂环基团 - （O）n -R 7基团; 卤素; 氰基 羟基; 氨基; 和任选取代的单或二-C 1-5烃基 - 氨基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成具有8至12个环成员的任选取代的双环杂环基，其中多达5个环成员是选自氧，氮和硫的杂原子。 这些组合具有作为Hsp90和/或糖原合酶激酶-3和/或细胞周期蛋白依赖性激酶和/或极光激酶抑制剂的活性。
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公开(公告)号：US08479718B2
公开(公告)日：2013-07-09
申请号：US13507072
申请日：2012-05-31
Applicant: Alexander Nelson Brooks , James Gallagher Daley
Inventor： Alexander Nelson Brooks , James Gallagher Daley
CPC classification number: F02B37/12 , B60W2710/0644 , B60Y2400/435 , F01N3/20 , F01N9/00 , F02B29/0412 , F02B33/40 , F02B37/013 , F02B37/18 , F02B37/20 , F02B43/10 , F02B73/00 , F02C7/26 , F02D19/024 , F02D29/06 , F02D41/0007 , F02D41/0025 , F02D41/065 , F02D41/083 , F02D41/1446 , F02M21/0206 , Y02T10/144 , Y02T10/146 , Y02T10/32
Abstract: A hydrogen fueled powerplant including an internal combustion engine that drives a motor-generator, and has a two-stage turbocharger, for an aircraft. A control system controls the operation of the motor-generator to maintain the engine at a speed selected based on controlling the engine equivalence ratio. The control system controls an afterburner, an intercooler and an aftercooler to maximize powerplant efficiency. The afterburner also adds power to the turbochargers during high-altitude restarts. The turbochargers also include motor-generators that extract excess power from the exhaust.
Abstract translation: 一种氢燃料动力装置，包括用于飞机的驱动电动发电机的内燃机，并具有两级涡轮增压器。 控制系统控制电动发电机的运行，以将发动机维持在基于控制发动机当量比所选择的速度。 控制系统控制加力燃烧器，中间冷却器和后冷器以最大限度地发挥动力装置效率。 在高空重启时，补燃器还增加了涡轮增压器的功率。 涡轮增压器还包括从排气中抽取多余动力的电动发电机。
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公开(公告)号：US20130074812A1
公开(公告)日：2013-03-28
申请号：US13507160
申请日：2012-06-08
Applicant: Alexander Nelson Brooks , James Gallagher Daley , Bart Dean Hibbs
Inventor： Alexander Nelson Brooks , James Gallagher Daley , Bart Dean Hibbs
CPC classification number: F02B43/00 , F01P2050/20 , F01P2060/02 , F01P2060/10 , F02B29/0412 , F02B29/0493 , F02C6/12 , F02C7/143 , F02C7/16 , F02C7/224 , F02M31/02 , F02M31/16 , F02M31/20 , F05D2260/205 , Y02T10/126 , Y02T10/146 , Y02T50/675
Abstract: A high-altitude aircraft powerplant including an engine, a two-stage turbocharger having an intercooler and an aftercooler, a cryogenic hydrogen fuel source, and a cooling system including a hydrogen heat exchanger. Aided by a ram-air cooler that cools a coolant to a near-ambient temperature, the heat exchanger is configured to heat the hydrogen using the coolant, and to cool the coolant to a temperature well below the ambient temperature during high-altitude flight. The intercooler and aftercooler use the sub-ambient temperature coolant, as does a separate sensor. The ram-air cooler includes a front portion and a rear portion. The cooling system includes three cooling loops which respectively incorporate only the front portion, only the rear portion, and both portions of the ram-air cooler.
Abstract translation: 包括发动机的高空飞机动力装置，具有中间冷却器和后冷器的两级涡轮增压器，低温氢燃料源和包括氢热交换器的冷却系统。 在冷却剂冷却至接近环境温度的冲压空气冷却器的帮助下，热交换器被配置为使用冷却剂加热氢气，并且在高空飞行期间将冷却剂冷却至远低于环境温度的温度。 中间冷却器和后冷却器与单独的传感器一样使用次环境温度的冷却液。 冲压空气冷却器包括前部和后部。 冷却系统包括三个冷却回路，其仅分别仅包括前部，后部和压缩空气冷却器的两个部分。
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公开(公告)号：US08385709B2
公开(公告)日：2013-02-26
申请号：US11779824
申请日：2007-07-18
Applicant: Mark Robert Hawley , Jeremy James Gallagher , Walter Dean Takisaki , James Patrick Jenkins
Inventor： Mark Robert Hawley , Jeremy James Gallagher , Walter Dean Takisaki , James Patrick Jenkins
Abstract: Structured cabling solutions may include techniques and systems usable to route, organize, and otherwise manager wires, optical fibers, and other cables. Structured cabling solutions may include one or more chassis coupled to and movable relative to a frame to provide access to signal connectors on the chassis. Structured cabling solutions may also include labeling schemes that identify patch connectors that correspond to outlets in a structured cabling installation.
Abstract translation: 结构化布线解决方案可以包括可用于路由，组织和以其他方式管理电线，光纤和其他电缆的技术和系统。 结构化布线解决方案可以包括耦合到框架并相对于框架可移动的一个或多个底板，以提供对底盘上的信号连接器的访问。 结构化布线解决方案还可以包括识别对应于结构化布线设备中的插座的贴片连接器的标签方案。
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公开(公告)号：US08196862B2
公开(公告)日：2012-06-12
申请号：US12586631
申请日：2009-09-23
Applicant: Alexander Nelson Brooks , James Gallagher Daley , Bart Dean Hibbs
Inventor： Alexander Nelson Brooks , James Gallagher Daley , Bart Dean Hibbs
IPC: B64D27/00
CPC classification number: F02B43/00 , F01P2050/20 , F01P2060/02 , F01P2060/10 , F02B29/0412 , F02B29/0493 , F02C6/12 , F02C7/143 , F02C7/16 , F02C7/224 , F02M31/02 , F02M31/16 , F02M31/20 , F05D2260/205 , Y02T10/126 , Y02T10/146 , Y02T50/675
Abstract: A high-altitude aircraft powerplant including an engine, a two-stage turbocharger having an intercooler and an aftercooler, a cryogenic hydrogen fuel source, and a cooling system including a hydrogen heat exchanger. Aided by a ram-air cooler that cools a coolant to a near-ambient temperature, the heat exchanger is configured to heat the hydrogen using the coolant, and to cool the coolant to a temperature well below the ambient temperature during high-altitude flight. The intercooler and aftercooler use the sub-ambient temperature coolant, as does a separate sensor. The ram-air cooler includes a front portion and a rear portion. The cooling system includes three cooling loops which respectively incorporate only the front portion, only the rear portion, and both portions of the ram-air cooler.
Abstract translation: 包括发动机的高空飞机动力装置，具有中间冷却器和后冷器的两级涡轮增压器，低温氢燃料源和包括氢热交换器的冷却系统。 在冷却剂冷却至接近环境温度的冲压空气冷却器的帮助下，热交换器被配置为使用冷却剂加热氢气，并且在高空飞行期间将冷却剂冷却至远低于环境温度的温度。 中间冷却器和后冷却器与单独的传感器一样使用次环境温度的冷却液。 冲压空气冷却器包括前部和后部。 冷却系统包括三个冷却回路，其仅分别仅包括前部，后部和压缩空气冷却器的两个部分。
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Patent Agency Ranking
公开(公告)号：US20110159111A1
公开(公告)日：2011-06-30
申请号：US12306383
申请日：2007-06-29
Applicant: Jayne Elizabeth Curry , Neil James Gallagher , John Francis Lyons , Neil Thomas Thompson
IPC: A61K33/24 , A61P35/00 , A61K31/5377 , A61K31/7072
CPC classification number: A61K31/445 , A61K31/4155 , A61K31/416 , A61K31/4415 , A61K31/5377 , A61K2300/00
Abstract: The invention provides combinations of an ancillary compound of the formula (0): and a compound of the formula (I′): Also provided are crystalline forms of the constituent compounds, methods for making them and their uses in treating cancers.
Abstract translation: 本发明提供式（O）的辅助化合物与式（I'）的化合物的组合：还提供了组成化合物的结晶形式，其制备方法及其在治疗癌症中的用途。
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公开(公告)号：US20110002879A1
公开(公告)日：2011-01-06
申请号：US12752772
申请日：2010-04-01
Applicant: Jayne Elizabeth CURRY , John Francis LYONS , Matthew Simon SQUIRES , Neil Thomas THOMPSON , Kyla Merriom THOMPSON , Paul Graham WYATT , Neil James GALLAGHER
Inventor： Jayne Elizabeth CURRY , John Francis LYONS , Matthew Simon SQUIRES , Neil Thomas THOMPSON , Kyla Merriom THOMPSON , Paul Graham WYATT , Neil James GALLAGHER
IPC: A61K38/19 , A61K31/415 , A61K31/4439 , A61K31/4196 , A61K31/454 , A61K31/496 , A61K31/4178 , A61K31/5377 , A61K31/497 , A61K31/4155 , A61K31/4709 , A61K31/422 , A61K31/506 , A61K31/541 , A61K31/4545 , A61K31/437 , A61K31/444 , A61K31/4375 , A61K39/395 , A61K38/22 , A61K31/69 , A61K31/665 , A61K31/573 , A61K31/7076 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K31/675 , A61K31/7048 , A61K38/14 , A61K38/18 , A61K31/663 , A61K31/522 , A61P35/00
CPC classification number: A61K45/06 , A61K31/415 , A61K31/4439 , A61K31/497 , A61K33/24 , A61K2300/00
Abstract: The invention provides a combination comprising a cytotoxic compound, a signalling inhibitor, an ancillary agent, or two or more further anti-cancer agents, and a compound having the formula (Ib): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4—; A is a bond, C═O, NRg(C═O) or O(C═O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from fluorine, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).
Abstract translation: 本发明提供了包含细胞毒性化合物，信号传导抑制剂，辅助剂或两种或更多种其它抗癌剂和具有式（Ib）的化合物或其盐或互变异构体或N-氧化物或溶剂合物的组合： 其中X是基团R 1 -A-NR 4 - ; A是键，C = O，NR g（C = O）或O（C = O），其中R g是氢或任选被羟基或C 1-4烷氧基取代的C 1-4烃基; Y是长度为1,2或3个碳原子的键或亚烷基链; R1是具有3-12个环成员的碳环或杂环基; 或任选被一个或多个选自氟，羟基，C 1-4烃氧基，氨基，一或二-C 1-4烃基氨基的取代基取代的C 1-8烃基，以及具有3-12个环成员的碳环或杂环基， 并且其中所述烃基的1或2个碳原子可以任选地被选自O，S，NH，SO，SO 2的原子或基团取代; R2是氢; 卤素; C 1-4烷氧基（如甲氧基）; 或任选被卤素（例如氟），羟基或C 1-4烷氧基（例如甲氧基）取代的C 1-4烃基; R3选自具有3至12个环成员的碳环和杂环基; 和R 4是氢或任选被卤素（例如氟），羟基或C 1-4烷氧基（例如甲氧基）取代的C 1-4烃基。
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公开(公告)号：US20080296060A1
公开(公告)日：2008-12-04
申请号：US11779826
申请日：2007-07-18
Applicant: Mark Robert Hawley , Jeremy James Gallagher , Walt Dean Takisaki , James Patrick Jenkins
IPC: H05K7/14
Abstract: Structured cabling solutions may include techniques and systems usable to route, organize, and otherwise manager wires, optical fibers, and other cables. Structured cabling solutions may include one or more chassis coupled to and movable relative to a frame to provide access to signal connectors on the chassis. Structured cabling solutions may also include labeling schemes that identify patch connectors that correspond to outlets in a structured cabling installation.
Abstract translation: 结构化布线解决方案可以包括可用于路由，组织和以其他方式管理电线，光纤和其他电缆的技术和系统。 结构化布线解决方案可以包括耦合到框架并相对于框架可移动的一个或多个底板，以提供对底盘上的信号连接器的访问。 结构化布线解决方案还可以包括识别对应于结构化布线设备中的插座的贴片连接器的标签方案。
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公开(公告)号：US07276873B2
公开(公告)日：2007-10-02
申请号：US10698574
申请日：2003-10-31
Applicant: Thomas James Gallagher , Hong Jiang , Sergei Kolomeitsev , John R. Suriano , Joseph P. Whinnery
Inventor： Thomas James Gallagher , Hong Jiang , Sergei Kolomeitsev , John R. Suriano , Joseph P. Whinnery
CPC classification number: B62D5/0487 , B62D5/0484 , H02P29/02
Abstract: A fault-handling system for a 2-phase motor. When an electric motor is used for power assist in a steering system in a vehicle, malfunctions can cause loss of assist, and detectable vibration. The invention utilizes a 2-phase motor in such an application, and implements alternate modes of operation when certain malfunctions occur, thereby maintaining the assist function in situations wherein the function would otherwise be lost or reduced.
Abstract translation: 2相电机故障处理系统。 当电动机用于车辆转向系统的动力辅助时，故障可能导致辅助失效和可检测的振动。 本发明在这种应用中使用了一个2相电动机，并且在发生某些故障时实现了另一种操作模式，从而在功能否则将丢失或减少的情况下保持辅助功能。
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公开(公告)号：US06699163B2
公开(公告)日：2004-03-02
申请号：US09978069
申请日：2001-10-17
Applicant: James Gallagher
Inventor： James Gallagher
IPC: A63B2600
CPC classification number: A63B21/00047 , A63B2023/006 , Y10S482/907
Abstract: A stretching apparatus for use on a golf course provides a wall with a top ridge, a reclined plane and a curb platform, each capable of supporting all or part of a human body. The top ridge may have at its opposite ends, multiple horizontal levels of differing heights. The wall has an obverse surface against which the reclined plane is disposed, and a reverse surface against which the curb platform is disposed. The stretching center may have stilts that elevate the reclined plane above the ground. The preferred embodiment of the stretching center includes a balancing handhold at a centered portion of the wall midway between it opposite ends, extending higher than the multiple levels of the top ridge, for providing balancing support to persons performing stretching exercises on the wall or the curb platform.
Abstract translation: 在高尔夫球场上使用的拉伸装置提供具有顶部脊，倾斜平面和路缘平台的墙壁，每个能够支撑人体的全部或一部分。 顶部脊可能在其相对端具有不同高度的多个水平水平。 所述壁具有倾斜平面所设置的正面，以及设置所述路缘平台的反面。 伸展中心可能有一个将斜倚的平面提升到地面以上的高跷。 拉伸中心的优选实施例包括在其相对端之间的中间部分的中心部分处的平衡手柄，其延伸高于顶部脊的多个水平面，以向在墙壁或路边上进行伸展运动的人提供平衡支撑 平台。
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