公开(公告)号：US20170115651A1

公开(公告)日：2017-04-27

申请号：US14920026

申请日：2015-10-22

Applicant: Macau University of Science and Technology

Inventor： Naiqi Wu ,  Fajun Yang ,  Yan Qiao ,  Mengchu Zhou

IPC: G05B19/042 ,  G05B15/02

CPC classification number: G05B19/0426 ,  G05B19/41865 ,  G05B2219/32291 ,  G05B2219/45031 ,  Y02P90/20 ,  Y10S901/09

Abstract: A method determines an optimized production schedule of a production line including a hybrid multi-cluster tool formed by a plurality of single-arm tools and dual-arm tools interconnected with each other. The method includes determining time for individual operations of a robotic arm and a processing module in the plurality of single-arm tools and dual-arm tools; determining robot waiting time of the single-arm tools and dual-arm tools based on the time for individual operations and different connection relationships of the plurality of single-arm tools and dual-arm tools; determining whether the optimized production schedule exists using the determined waiting time, wherein the optimized production schedule only exists if the hybrid multi-cluster tool is process-dominant where the robot activity time of the plurality of single-arm tools and dual-arm tools is substantially shorter than processing time at the processing module; and determining the optimized production schedule if the optimized production schedule exists.

公开(公告)号：US09624237B2

公开(公告)日：2017-04-18

申请号：US14744040

申请日：2015-06-19

Applicant: Macau University of Science and Technology

Inventor： Jiang Pi ,  Jiye Cai ,  Hua Jin

IPC: C07D493/08

CPC classification number: C07D493/08

Abstract: The present invention relates to an oridonin functionalized selenium nanoparticle, method of preparing and use thereof for anti-cancer and anti-inflammatory treatments. The present invention provides oridonin functionalized selenium nanoparticle that is stable, water soluble and storable.

公开(公告)号：US09597299B2

公开(公告)日：2017-03-21

申请号：US14624574

申请日：2015-02-17

Applicant: Macau University of Science and Technology

Inventor： Lai-Han Leung ,  Xing-Xing Fan ,  Liang Liu ,  Zebo Jiang

IPC: A61K31/661 ,  A61K31/09

CPC classification number: A61K31/09

Abstract: The present invention relates to a method for treating gefitinib-resistant non-small-cell lung cancer (NSCLC) comprising administering an effective amount of a resveratrol analog, (Z)3,4,5,4′-tetramethoxystilbene (TMS), to a subject in need thereof. The present invention also relates to a method for inducing apoptosis in gefitinib-resistant NSCLC cells comprising contacting the resveratrol analog to the cells at an effective amount. The present methods are mediated by different signaling pathways connected to cell proliferation and differentiation such as mTOR, JNK, and certain EGFR phosphorylated tyrosine kinase.

公开(公告)号：US09561221B2

公开(公告)日：2017-02-07

申请号：US14985417

申请日：2015-12-31

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Liang Liu ,  Jingrong Wang

IPC: A61K31/4725 ,  A61K31/4745 ,  A61K31/4748

CPC classification number: A61K31/4745 ,  A61K31/4725 ,  A61K31/4748

Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.

公开(公告)号：US20170026964A1

公开(公告)日：2017-01-26

申请号：US15219293

申请日：2016-07-26

Applicant: Macau University of Science and Technology

Inventor： Qinglin ZHAO ,  Caihong KAI ,  Hanxu ZHENG

IPC: H04W72/04 ,  H04W4/00 ,  H04W52/02 ,  H04W72/00 ,  H04W72/12 ,  H04J3/16

CPC classification number: H04W52/0219 ,  H04B17/3912 ,  H04W4/70 ,  Y02D70/00 ,  Y02D70/22

Abstract: The throughput of a wireless network can be boosted by network coding (NC). The present invention combines NC-aware routing and TDMA-based MAC protocol for energy-efficient design in the wireless network, and provides a method thereof. An optimization model, which is a minimum energy consumption model (MECM), is formulated for minimizing the energy consumption for accomplishing a set of flow transmissions. In particular, based on a set of user traffic-flow demands, a NC-aware traffic-flow assignment that minimizes a total energy consumption of packets delivering to meet the user traffic-flow demands is determined. Thereafter, given the optimal flow assignment, a minimum timeslots model (MTM) which leads to a TDMA-based scheduling strategy at the MAC layer is developed. The MTM is to minimize the total number of timeslots required for transmission under a condition that the NC-aware traffic-flow assignment as already determined is accomplishable.

Abstract translation: 无线网络的吞吐量可以通过网络编码（NC）来提升。 本发明将无线网络中的基于NC感知路由和基于TDMA的MAC协议结合在节能设计中，并提供了其方法。 制定了最小化能量消耗模型（MECM）的优化模型，用于最小化能量消耗以实现一组流量传输。 特别地，基于一组用户业务流量需求，确定最小化分组传送以满足用户业务流量需求的总能量消耗的NC感知业务流分配。 此后，给定最佳流分配，开发了在MAC层导致基于TDMA的调度策略的最小时隙模型（MTM）。 在已经确定的NC感知业务流分配是可实现的条件下，MTM将使传输所需的时隙的总数最小化。

公开(公告)号：US20170026913A1

公开(公告)日：2017-01-26

申请号：US15219291

申请日：2016-07-26

Applicant: Macau University of Science and Technology

Inventor： Qinglin ZHAO ,  Yuan Wu ,  Yanfei He ,  Jiachao Chen ,  Liping Qian

IPC: H04W52/24 ,  H04W52/52 ,  H04W52/26

CPC classification number: H04W52/243 ,  H04W52/267 ,  H04W52/52

Abstract: The present invention provides a method of power control for a plurality of secondary users (SUs), or unlicensed users, in a cognitive radio network having a plurality of primary users (PUs), or licensed users. The method comprises determining an optimal power level for each of the SUs such that a total throughput of all the SUs is maximized while satisfying an individual throughput requirement of each SU and an interference limit constraint of the PUs. In particular, a case having two SUs is considered.

Abstract translation: 本发明提供了一种在具有多个主用户（PU）或许可用户的认知无线电网络中的多个次要用户（SU）或非许可用户的功率控制的方法。 该方法包括确定每个SU的最佳功率电平，使得所有SU的总吞吐量最大化，同时满足每个SU的单个吞吐量要求和PU的干扰限制约束。 特别地，考虑具有两个SU的情况。

公开(公告)号：US20170024529A1

公开(公告)日：2017-01-26

申请号：US15219484

申请日：2016-07-26

Applicant: Macau University of Science and Technology

Inventor： Yong LIANG ,  Hua CHAI ,  Xiao-Ying LIU

IPC: G06F19/00 ,  G06N99/00 ,  G06F17/18 ,  G06N7/00

CPC classification number: G16H50/20 ,  G06N20/00 ,  G16B10/00 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00 ,  Y02A90/26

Abstract: The present invention provides a novel semi-supervised learning method based on the combination of the Cox model and the accelerated failure time (AFT) model, each of which is regularized with L1/2 regularization for high-dimensional and low sample size biological data. In this semi-supervised learning framework, the Cox model can classify the “low-risk” or a “high-risk” subgroup though samples as many as possible to improve its predictive accuracy. Meanwhile, the AFT model can estimate the censored data in the subgroup, in which the samples have the same molecular genotype. Combined with L1/2 regularization, some genes can be selected by the Cox model and the AFT model and they are significantly relevant with the cancer.

Abstract translation: 本发明提供了一种基于Cox模型和加速故障时间（AFT）模型的组合的新型半监督学习方法，其中每个模型对于高维和低样本量的生物数据进行L1 / 2正则化。 在这个半监督学习框架下，Cox模型可以尽可能多地分类“低风险”或“高风险”亚组，以提高其预测精度。 同时，AFT模型可以估计亚组中的检测数据，其中样本具有相同的分子基因型。 结合L1 / 2正则化，可以通过Cox模型和AFT模型选择一些基因，并且它们与癌症显着相关。

公开(公告)号：US20160257694A1

公开(公告)日：2016-09-08

申请号：US14744040

申请日：2015-06-19

Applicant: Macau University of Science and Technology

Inventor： Jiang PI ,  Jiye CAI ,  Hua JIN

IPC: C07D493/08

CPC classification number: C07D493/08

Abstract: The present invention relates to an oridonin functionalized selenium nanoparticle, method of preparing and use thereof for anti-cancer and anti-inflammatory treatments. The present invention provides oridonin functionalized selenium nanoparticle that is stable, water soluble and storable.

Abstract translation: 本发明涉及一种oridonin官能化硒纳米粒子，其制备方法及其用于抗癌和抗炎治疗。 本发明提供稳定，水溶性且可储存的卵磷脂官能化硒纳米粒子。

公开(公告)号：US09364469B1

公开(公告)日：2016-06-14

申请号：US14925996

申请日：2015-10-29

Applicant: Macau University of Science and Technology

Inventor： Lai-Han Leung ,  Xiao-Jun Yao ,  Kam Wai Wong ,  Liang Liu ,  Xi Chen

IPC: A61K31/4439

CPC classification number: A61K31/4439

Abstract: The present invention discloses a method of treating gefitinib-resistant non-small-cell lung cancer, comprising administering an effective amount of D561-0775. A pharmaceutical composition comprising D561-0775 admixed with a pharmaceutical carrier for treating Gefitinib-resistant non-small-cell lung cancer is also disclosed therein.

Abstract translation: 本发明公开了一种治疗耐吉非替尼的非小细胞肺癌的方法，包括给予有效量的D561-0775。 还公开了包含D561-0775的药物组合物，其与药物载体混合以治疗吉非替尼耐药性非小细胞肺癌。

公开(公告)号：US20160158163A1

公开(公告)日：2016-06-09

申请号：US14624574

申请日：2015-02-17

Applicant: Macau University of Science and Technology

Inventor： Lai-Han LEUNG ,  Xing-Xing FAN ,  Liang LIU ,  Zebo JIANG

IPC: A61K31/09

CPC classification number: A61K31/09

Abstract: The present invention relates to a method for treating gefitinib-resistant non-small-cell lung cancer (NSCLC) comprising administering an effective amount of a resveratrol analogue, (Z)3,4,5,4′-tetramethoxystilbene (TMS), to a subject in need thereof. The present invention also relates to a method for inducing apoptosis in gefitinib-resistant NSCLC cells comprising contacting the resveratrol analogue to the cells at an effective amount. The present methods are mediated by different signaling pathways connected to cell proliferation and differentiation such as mTOR, JNK, and certain EGFR phosphorylated tyrosine kinase.

Abstract translation: 本发明涉及一种治疗吉非替尼耐药性非小细胞肺癌（NSCLC）的方法，包括将有效量的白藜芦醇类似物（Z）3,4,5,4'-四甲氧基二苯乙烯（TMS）给予 有需要的科目。 本发明还涉及一种诱导吉非替尼耐药NSCLC细胞凋亡的方法，包括以有效量将白藜芦醇类似物与细胞接触。 本发明的方法是通过与细胞增殖和分化相关的不同信号通路介导的，例如mTOR，JNK和某些EGFR磷酸化酪氨酸激酶。