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公开(公告)号：US08993600B2
公开(公告)日：2015-03-31
申请号：US12114935
申请日：2008-05-05
Applicant: Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
Inventor： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC: A61K31/443 , C07D405/12 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D405/14
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20130245011A1
公开(公告)日：2013-09-19
申请号：US13887839
申请日：2013-05-06
Applicant: Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
Inventor： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC: A61K31/5377 , A61K45/06 , C07D405/14 , A61K31/4545 , C07D405/12 , A61K31/443
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract translation: 本发明化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTC”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US07973038B2
公开(公告)日：2011-07-05
申请号：US12768894
申请日：2010-04-28
Applicant: Sara S. Hadida Ruah , Matthew Hamilton , Mark T. Miller , Peter D. J. Grootenhuis , Brian Richard Bear , Jason McCartney , Jinglan Zhou
Inventor： Sara S. Hadida Ruah , Matthew Hamilton , Mark T. Miller , Peter D. J. Grootenhuis , Brian Richard Bear , Jason McCartney , Jinglan Zhou
IPC: A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4418 , A61K31/443
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20100210638A1
公开(公告)日：2010-08-19
申请号：US12768894
申请日：2010-04-28
Applicant: Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
Inventor： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/501 , A61K31/4418 , A61K31/4709 , A61P3/06 , A61P3/08 , A61P25/00 , A61P21/00 , A61P7/00
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US07741321B2
公开(公告)日：2010-06-22
申请号：US11594431
申请日：2006-11-08
Applicant: Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
Inventor： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC: A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4418 , A61K31/443
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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Patent Agency Ranking
公开(公告)号：US20070163545A1
公开(公告)日：2007-07-19
申请号：US11333052
申请日：2006-01-17
Applicant: John Beardmore , Matthew Hamilton
Inventor： John Beardmore , Matthew Hamilton
CPC classification number: F02M55/04 , F02M55/025 , F02M61/14 , F02M2200/306 , F02M2200/9015
Abstract: An isolated fuel delivery system for an internal combustion engine includes a fuel rail with a clamping method operable to retain an isolating member with respect to the fuel rail. The isolating member operates to isolate the vibratory motion of the fuel delivery system form the attachment point or points. The attachment point is typically a cylinder head of the internal combustion engine. Additionally, an isolating ring assembly is provided having a first and second stiffening member with an isolating ring member disposed therebetween. The isolating ring assembly is disposed between a fuel injector of the isolated fuel delivery system and the cylinder head. The isolating ring member operates to isolate the vibratory motion of the fuel injector from the internal combustion engine.
Abstract translation: 用于内燃机的隔离燃料输送系统包括具有可操作以相对于燃料轨道保持隔离构件的夹紧方法的燃料轨道。 隔离构件用于隔离燃料输送系统的振动运动形成附接点或点。 附接点通常是内燃机的气缸盖。 另外，提供了隔离环组件，其具有第一和第二加强构件，其间设置有隔离环构件。 隔离环组件设置在隔离燃料输送系统的燃料喷射器和气缸盖之间。 隔离环构件用于隔离燃料喷射器与内燃机的振动运动。
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公开(公告)号：US20200092535A1
公开(公告)日：2020-03-19
申请号：US16686677
申请日：2019-11-18
Applicant: Wally Haas , Jennifer Campbell-Correa , Matthew Hamilton , Stephen Hill , Jordan Peckham , Chuck Rumbolt
Inventor： Wally Haas , Jennifer Campbell-Correa , Matthew Hamilton , Stephen Hill , Jordan Peckham , Chuck Rumbolt
IPC: H04N13/351 , H01L27/32 , G02B27/22 , G02B26/08 , H04N13/398 , H04N13/363 , H04N13/32 , H01L51/52
Abstract: The present disclosure relates to a directional pixel for a high-angular resolution, wide field of view, multiple view display. The design teaches a directional pixel comprising a substrate, one or more pixel driving circuits, one or more nano- or micro-scale subpixels, and one or more directional optical guiding surfaces, wherein each of said one or more subpixels is comprised of a light emitting device emitting a light beam and an optical microcavity housing said light emitting device. The optical microcavity is comprised of a plurality of reflective surfaces to specifically manipulate and tune said light beam, wherein one or more of said reflective surfaces is a light propagating reflective surface which propagates said light beam out of said microcavity, and said light propagating reflective surface is connected to said one or more directional optical guiding surfaces to direct said light beam at a specific angle. A high-angular resolution, multiple-view light-field display is created by deploying a plurality of directional pixels into a directional pixel array system.
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公开(公告)号：US08759335B2
公开(公告)日：2014-06-24
申请号：US11047366
申请日：2005-01-31
Applicant: Sara Hadida Ruah , Peter Grootenhuis , Mark Miller , Matthew Hamilton
Inventor： Sara Hadida Ruah , Peter Grootenhuis , Mark Miller , Matthew Hamilton
IPC: C07D417/06 , C07D409/12 , C07D277/40 , C07D277/46 , C07D271/10 , C07D405/12 , C07D413/12 , C07D285/135 , C07D409/14 , C07D277/54 , C07D407/12 , C07D233/46 , C07D417/04 , C07D231/40 , C07D277/82 , C07D233/88 , C07D493/10 , C07D263/48 , C07D417/14 , C07D417/12 , C07D271/113
CPC classification number: C07D231/40 , C07D233/46 , C07D233/88 , C07D263/48 , C07D271/10 , C07D271/113 , C07D277/40 , C07D277/46 , C07D277/54 , C07D277/82 , C07D285/135 , C07D317/60 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D493/10
Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：US20130245010A1
公开(公告)日：2013-09-19
申请号：US13871349
申请日：2013-04-26
Applicant: Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
Inventor： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC: C07D405/12 , C07D405/14 , A61K31/4545 , A61K31/5377 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/497 , A61K31/443 , A61K31/444
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract translation: 本发明化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTC”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20130237568A1
公开(公告)日：2013-09-12
申请号：US13871356
申请日：2013-04-26
Applicant: Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
Inventor： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC: A61K31/443 , A61K45/06 , C07D405/12
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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