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公开(公告)号：US20170196862A2
公开(公告)日：2017-07-13
申请号：US14876525
申请日：2015-10-06
Applicant: Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Ciemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
Inventor： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Ciemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC: A61K31/506 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D213/82
CPC classification number: A61K31/506 , A61J1/035 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , C07D209/18 , C07D209/42 , C07D209/49 , C07D213/64 , C07D213/73 , C07D213/82 , C07D213/84 , C07D231/12 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D407/12 , C07D413/14 , C07D417/12
Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：US08829204B2
公开(公告)日：2014-09-09
申请号：US11841646
申请日：2007-08-20
Applicant: Sara Hadida-Ruah , Anna Hazlewood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
Inventor： Sara Hadida-Ruah , Anna Hazlewood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC: C07D209/04 , C07D217/06 , C07D215/56 , C07D413/12 , C07D215/233 , C07D417/12 , C07D409/12 , C07D215/38 , C07D223/16 , C07D405/12 , C07D311/58 , C07D215/227 , C07D209/18 , C07D213/73 , C07D209/42 , C07D213/20 , C07D209/14 , C07D209/08 , C07D279/16 , C07D265/36 , C07D209/94 , C07D471/10 , C07D401/12 , C07C215/76 , C07D401/14
CPC classification number: C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：US08586615B2
公开(公告)日：2013-11-19
申请号：US13178677
申请日：2011-07-08
Applicant: Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
Inventor： Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
IPC: A61K31/425 , C07D277/00
CPC classification number: C07D417/14 , A61K31/427
Abstract: The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
Abstract translation: 本发明涉及囊性纤维化跨膜电导调节剂（“CFTR”）的调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗CFTR介导的疾病的方法。
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公开(公告)号：US08575209B2
公开(公告)日：2013-11-05
申请号：US12948162
申请日：2010-11-17
Applicant: Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick F. Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Numa , Xiaoqing Yang
Inventor： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick F. Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Numa , Xiaoqing Yang
IPC: A61K31/36 , C07D405/12
CPC classification number: A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20130237569A1
公开(公告)日：2013-09-12
申请号：US13871364
申请日：2013-04-26
Applicant: Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
Inventor： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC: A61K31/443 , A61K45/06
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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Patent Agency Ranking
公开(公告)号：US20130035327A1
公开(公告)日：2013-02-07
申请号：US13647034
申请日：2012-10-08
Applicant: Sara Hadida-Ruah , Anna Hazlewood , Peter Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
Inventor： Sara Hadida-Ruah , Anna Hazlewood , Peter Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC: A61K31/47 , C07D401/12 , A61K31/475 , A61K31/4709 , C07D413/12 , A61K31/5377 , A61K31/55 , C07D417/12 , A61K31/538 , C07D471/04 , C07D471/10 , A61K31/4747 , A61K31/5415 , A61K31/496 , C07C215/76 , C07D209/04 , A61P11/08 , A61P31/00 , A61P29/00 , A61P37/00 , A61P7/04 , A61P3/10 , A61P35/00 , A61P5/00 , A61P25/28 , A61P11/00 , A61P27/04 , C12N5/071 , C12Q1/02 , C07D215/56
CPC classification number: C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Abstract translation: 本发明涉及ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20120322798A1
公开(公告)日：2012-12-20
申请号：US13595225
申请日：2012-08-27
Applicant: Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
Inventor： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC: A61K31/4439 , A61K31/4545 , A61K31/5377 , A61K31/444 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/497 , A61K31/4709 , A61P3/06 , A61P3/10 , A61P17/00 , A61P5/00 , A61P25/00 , A61P25/28 , A61P25/16 , A61K31/443
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（CFTC）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08324207B2
公开(公告)日：2012-12-04
申请号：US13069889
申请日：2011-03-23
Applicant: Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Fredrick van Goor
Inventor： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Fredrick van Goor
IPC: A61K31/5355 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/4412 , A61K31/4418 , A61K31/443
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（CFTR）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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9.发明申请HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS 有权作为离子通道调节剂的杂环氯仿 - 哌啶胺公开(公告)号：US20110306607A1
公开(公告)日：2011-12-15
申请号：US13102335
申请日：2011-05-06
Applicant: Sara Sabina Hadida-Ruah , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Vijayalaksmi Arumugam , Nicole Hilgraf , Jason McCartney , Peter Diederik Jan Grootenhuis , Corey Anderson , Mehdi Numa , Bryan A. Frieman , Brian Richard Bear , James Philip Johnson, JR.
Inventor： Sara Sabina Hadida-Ruah , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Vijayalaksmi Arumugam , Nicole Hilgraf , Jason McCartney , Peter Diederik Jan Grootenhuis , Corey Anderson , Mehdi Numa , Bryan A. Frieman , Brian Richard Bear , James Philip Johnson, JR.
IPC: A61K31/5386 , C07D491/22 , A61K31/438 , A61P25/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/24 , A61P21/00 , A61P9/06 , A61P25/14 , A61P1/00 , A61P13/00 , A61P3/10 , A61P9/10 , A61P9/12 , A61P29/00 , A61P7/06 , A61P1/18 , A61P13/10 , A61P13/08 , C07D498/22
CPC classification number: C07D491/20 , C07D491/22 , C07D498/20 , C07D498/22 , C07D513/20
Abstract: The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环色烯 - 螺环哌啶酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20100087435A1
公开(公告)日：2010-04-08
申请号：US12630874
申请日：2009-12-04
Applicant: Sara Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Fredrick van Goor
Inventor： Sara Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Fredrick van Goor
IPC: A61K31/4439 , A61K31/4418 , A61K31/496 , A61K31/443 , A61K31/5377 , A61K31/506 , A61K31/497 , A61P43/00 , A61P11/00
CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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