公开(公告)号：US20080086180A1

公开(公告)日：2008-04-10

申请号：US11732157

申请日：2007-04-02

申请人： Omry Ben-Ezra ,  Tamir Ben-David ,  Ehud Cohen

发明人： Omry Ben-Ezra ,  Tamir Ben-David ,  Ehud Cohen

IPC分类号： A61N1/00

CPC分类号： A61N1/36007

摘要： Apparatus for treating a patient is provided, including an electrode device, which is configured to be placed in a vicinity of at least one gall bladder site of the patient selected from the group consisting of: a gall bladder, a neck of the gall bladder, a cystic duct, a hepatic duct, a common hepatic duct, a bile duct, a common bile duct, sensory fibers of the gall bladder, and a hepatic port. The apparatus further includes a control unit, which is configured to drive the electrode device to apply a current to the site, and to configure the current to induce weight loss of the patient. Other embodiments are also described.

摘要翻译： 提供了一种用于治疗患者的装置，包括电极装置，其被配置为放置在患者的至少一个胆囊部位附近，所述胆囊部位选自：胆囊，胆囊颈部， 囊性管，肝管，普通肝管，胆管，胆总管，胆囊感觉纤维和肝端口。 该装置还包括控制单元，其被配置为驱动电极装置将电流施加到现场，并且配置电流以引起患者的体重减轻。 还描述了其它实施例。

公开(公告)号：US20080065158A1

公开(公告)日：2008-03-13

申请号：US11517888

申请日：2006-09-07

申请人： Omry Ben-Ezra ,  Tamir Ben-David ,  Ehud Cohen

发明人： Omry Ben-Ezra ,  Tamir Ben-David ,  Ehud Cohen

IPC分类号： A61N1/00

CPC分类号： A61N1/36071 ,  A61N1/36114

摘要： Apparatus is provided including an electrode device and a control unit. The electrode device is configured to be coupled to a site of a subject selected from the group consisting of: a vagus nerve, an epicardial fat pad, a pulmonary vein, a carotid artery, a carotid sinus, a coronary sinus, a vena cava vein, a right ventricle, a right atrium, and a jugular vein. The control unit is configured to drive the electrode device to apply to the site a current in at least first and second bursts, the first burst including a plurality of pulses, and the second burst including at least one pulse, and set (a) a pulse repetition interval (PRI) of the first burst to be on average at least 20 ms, (b) an interburst interval between initiation of the first burst and initiation of the second burst to be less than 10 seconds, (c) an interburst gap between a conclusion of the first burst and the initiation of the second burst to have a duration greater than the average PRI, and (d) a burst duration of the first burst to be less than a percentage of the interburst interval between, the percentage being less than 67%. Other embodiments are also described.

摘要翻译： 提供了包括电极装置和控制单元的装置。 电极装置被配置为耦合到选自以下的对象的部位：迷走神经，心外膜脂肪垫，肺静脉，颈动脉，颈动脉窦，冠状窦，腔静脉 ，右心室，右心房和颈静脉。 所述控制单元被配置为驱动所述电极装置以至少第一和第二脉冲串向所述现场应用电流，所述第一脉冲串包括多个脉冲，所述第二脉冲串包括至少一个脉冲，并且设置（a） 脉冲重复间隔（PRI）平均至少为20ms，（b）第一脉冲串的起始与第二脉冲串的起始之间的间歇间隔小于10秒，（c）突发间隙 在第一突发的结论和第二突发的开始之间具有大于平均PRI的持续时间，以及（d）第一突发的突发持续时间小于突发间间隔的百分比，百分比为 小于67％。 还描述了其它实施例。

公开(公告)号：US07321793B2

公开(公告)日：2008-01-22

申请号：US10461696

申请日：2003-06-13

申请人： Omry Ben Ezra ,  Ehud Cohen ,  Tamir Ben David

发明人： Omry Ben Ezra ,  Ehud Cohen ,  Tamir Ben David

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： Apparatus for treating a subject suffering from spontaneous atrial fibrillation includes an electrode device, adapted to be coupled to a vagus nerve of the subject, and a control unit, adapted to drive the electrode device to apply an electrical current to the vagus nerve, and to configure the current to maintain the spontaneous AF for at least about 24 hours, so as to modify blood flow within the atria and reduce risk of thromboembolic events.

摘要翻译： 用于治疗患有自发性心房颤动的受试者的装置包括适于耦合到受试者的迷走神经的电极装置和适于驱动电极装置向迷走神经施加电流的控制单元，以及 配置电流以维持自发性AF至少约24小时，以便改变心房内的血流量并降低血栓栓塞事件的风险。

公开(公告)号：US09125567B2

公开(公告)日：2015-09-08

申请号：US12602787

申请日：2009-09-29

申请人： Yossi Gross ,  Itzik Avneri ,  Omry Ben Ezra ,  Ori Weisberg ,  Raanan Gefen

发明人： Yossi Gross ,  Itzik Avneri ,  Omry Ben Ezra ,  Ori Weisberg ,  Raanan Gefen

IPC分类号： A61B17/00 ,  A61B5/021 ,  A61B5/00 ,  A61B5/022

CPC分类号： A61B5/021 ,  A61B5/022 ,  A61B5/6862 ,  A61B5/6876

摘要： Apparatus is provided for reducing hypertension of a subject. A selective circumferential pressure applicator (60) includes at least two surfaces (61) that increase baroreceptor activity of the subject, by applying pressure to an artery (20) of the subject at two or more respective non-contiguous regions around the circumference of the artery, at a longitudinal site of the artery, such that between the non-contiguous regions, at the longitudinal site (a) there is at least one region (22) of the artery that is more relaxed than in the absence of the device, and (b) there is at least one region (21) of the artery that is more tense than in the absence of the device. A joint (63) couples the surfaces to each other. For at least a portion of the subject's cardiac cycle, the joint does not to contact the subject's artery. Other applications are also provided.

摘要翻译： 提供用于减少受试者的高血压的装置。 选择性周向压力施加器（60）包括至少两个增加受试者压力感受器活性的表面（61），所述至少两个表面（61）通过在受试者的动脉（20）周围的两个或更多个相邻的非连续区域周围施加压力 动脉，在动脉的纵向位置处，使得在不连续区域之间，在纵向位置（a）处，与没有装置相比，动脉的至少一个区域（22）比较松弛， 和（b）动脉的至少一个区域（21）比不存在装置时更紧张。 接头（63）将表面彼此连接。 对于受试者心脏周期的至少一部分，关节不接触受试者的动脉。 还提供其他应用。

公开(公告)号：US20140336723A1

公开(公告)日：2014-11-13

申请号：US14359137

申请日：2012-10-15

申请人： Omry Ben-Ezra ,  Viljem Fuchs ,  Andrej Tomeljak ,  Ami Dror ,  Todd Mattingly

发明人： Omry Ben-Ezra ,  Viljem Fuchs ,  Andrej Tomeljak ,  Ami Dror ,  Todd Mattingly

IPC分类号： A61N1/36 ,  A61N1/04

CPC分类号： A61N1/36046 ,  A61H5/00 ,  A61H2201/165 ,  A61H2201/5005 ,  A61N1/0484 ,  A61N1/36025

摘要： Active glasses for stimulating optic nerves of a user.

摘要翻译： 用于刺激用户的视神经的活动眼镜。

公开(公告)号：US08036745B2

公开(公告)日：2011-10-11

申请号：US11359266

申请日：2006-02-21

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/18

CPC分类号： A61N1/0556 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： A treatment method is provided, including identifying a subject as one who is selected to undergo an interventional medical procedure, and, in response to the identifying, reducing a likelihood of a potential adverse effect of the procedure by applying an electrical current to a parasympathetic site of the subject selected from the group consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a jugular vein of the subject, a right ventricle of the subject, a parasympathetic ganglion of the subject, and a parasympathetic nerve of the subject.

摘要翻译： 提供了一种治疗方法，包括将受试者识别为被选择进行介入医疗程序的受试者，并且响应于鉴定，通过将电流施加到副交感神经部位来减少手术的潜在不利影响的可能性 所述对象选自：受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，受试者的颈动脉，受试者的颈动脉窦，冠状窦 受试者，受试者的静脉静脉，受试者的颈静脉，受试者的右心室，受试者的副交感神经节和受试者的副交感神经。

公开(公告)号：US07904176B2

公开(公告)日：2011-03-08

申请号：US11517888

申请日：2006-09-07

申请人： Omry Ben-Ezra ,  Tamir Ben-David ,  Ehud Cohen

发明人： Omry Ben-Ezra ,  Tamir Ben-David ,  Ehud Cohen

IPC分类号： A61N1/32

CPC分类号： A61N1/36071 ,  A61N1/36114

摘要： Apparatus is provided including an electrode device and a control unit. The electrode device is configured to be coupled to a site of a subject selected from the group consisting of: a vagus nerve, an epicardial fat pad, a pulmonary vein, a carotid artery, a carotid sinus, a coronary sinus, a vena cava vein, a right ventricle, a right atrium, and a jugular vein. The control unit is configured to drive the electrode device to apply to the site a current in at least first and second bursts, the first burst including a plurality of pulses, and the second burst including at least one pulse, and set (a) a pulse repetition interval (PRI) of the first burst to be on average at least 20 ms, (b) an interburst interval between initiation of the first burst and initiation of the second burst to be less than 10 seconds, (c) an interburst gap between a conclusion of the first burst and the initiation of the second burst to have a duration greater than the average PRI, and (d) a burst duration of the first burst to be less than a percentage of the interburst interval between, the percentage being less than 67%. Other embodiments are also described.

摘要翻译： 提供了包括电极装置和控制单元的装置。 电极装置被配置为耦合到选自以下的对象的部位：迷走神经，心外膜脂肪垫，肺静脉，颈动脉，颈动脉窦，冠状窦，腔静脉 ，右心室，右心房和颈静脉。 所述控制单元被配置为驱动所述电极装置以至少第一和第二脉冲串向所述现场应用电流，所述第一脉冲串包括多个脉冲，所述第二脉冲串包括至少一个脉冲，并且设置（a） 脉冲重复间隔（PRI）平均至少为20ms，（b）第一脉冲串的起始与第二脉冲串的起始之间的间歇间隔小于10秒，（c）突发间隙 在第一突发的结论和第二突发的开始之间具有大于平均PRI的持续时间，以及（d）第一突发的突发持续时间小于突发间间隔的百分比，百分比为 小于67％。 还描述了其它实施例。

公开(公告)号：US07668602B2

公开(公告)日：2010-02-23

申请号：US11975169

申请日：2007-10-17

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/05

CPC分类号： A61N1/36114 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： A method is provided for treating a subject, including applying a current to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a vena cava vein of the subject, and an internal jugular vein of the subject. The method also includes configuring the current so as to treat a condition of the subject selected from the list consisting of: an autoimmune disease, an autoimmune inflammatory disease, multiple sclerosis, encephalitis, myelitis, immune-mediated neuropathy, myositis, dermatomyositis, polymyositis, inclusion body myositis, inflammatory demyelinating polyradiculoneuropathy, Guillain Barre syndrome, myasthenia gravis, inflammation of the nervous system, inflammatory bowel disease, Crohn's disease, ulcerative colitis, SLE (systemic lupus erythematosus), rheumatoid arthritis, vasculitis, polyarteritis nodosa, Sjogren syndrome, mixed connective tissue disease, glomerulonephritis, thyroid autoimmune disease, sepsis, meningitis, a bacterial infection, a viral infection, a fungal infection, sarcoidosis, hepatitis, and portal vein hypertension.

摘要翻译： 提供了一种用于治疗受试者的方法，包括将电流施加到从包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的动脉，受试者的颈动脉窦，受试者的腔静脉和受试者的颈内静脉。 该方法还包括配置电流以便治疗从以下列表中选择的受试者的状况：自身免疫疾病，自身免疫性炎性疾病，多发性硬化症，脑炎，脊髓炎，免疫介导的神经病，肌炎，皮肌炎，多发性肌炎， 包涵体肌炎，炎性脱髓鞘多发性神经病，吉兰巴利综合征，重症肌无力，神经系统炎症，炎性肠病，克罗恩病，溃疡性结肠炎，SLE（系统性红斑狼疮），类风湿性关节炎，血管炎，结节性多动脉炎，干燥综合征，混合 结缔组织病，肾小球性肾炎，甲状腺自身免疫性疾病，败血症，脑膜炎，细菌感染，病毒感染，真菌感染，结节病，肝炎和门静脉高血压。

公开(公告)号：US20080177338A1

公开(公告)日：2008-07-24

申请号：US11974951

申请日：2007-10-16

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/04

CPC分类号： A61N1/0556 ,  A61N1/36114

摘要： A method is provided, including identifying that a subject is at risk of suffering from atrial fibrillation (AF). Responsively to the identifying, a risk of an occurrence of an episode of the AF is reduced by applying an electrical current to a site of the subject selected from the group consisting of: a vagus nerve, a sinoatrial (SA) node fat pad, a pulmonary vein, a carotid artery, a carotid sinus, a coronary sinus, a vena cava vein, a jugular vein, an azygos vein, an innominate vein, and a subclavian vein, and configuring the current to stimulate autonomic nervous tissue in the site. Other embodiments are also described.

摘要翻译： 提供了一种方法，包括识别受试者处于心房颤动（AF）的风险。 响应于识别，通过向选自以下的组中的受试者的位点施加电流来减少AF的发作的风险：迷走神经，窦房（SA）节点脂肪垫， 肺静脉，颈动脉，颈动脉窦，冠状窦，腔静脉，颈静脉，纯合静脉，无名静脉和锁骨下静脉，并配置电流以刺激部位的自主神经组织。 还描述了其它实施例。

公开(公告)号：US20080125827A1

公开(公告)日：2008-05-29

申请号：US11978440

申请日：2007-10-29

申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/365

CPC分类号： A61B5/412 ,  A61B5/024 ,  A61B5/4029 ,  A61B5/4041 ,  A61B5/7217 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627

摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.

摘要翻译： 提供了包括适于联接到受试者的迷走神经的电极装置和控制单元的装置，所述控制单元适于驱动所述电极装置向所述迷走神经施加降低所述受试者心率变异性的电流。 还提供了一种方法，包括向受试者的迷走神经施加减少受试者心率变异性的电流。