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    PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS
    33.
    发明申请
    PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS 审中-公开
    哌啶和哌嗪衍生物作为SMO拮抗剂

    公开(公告)号：US20130053396A1

    公开(公告)日：2013-02-28

    申请号：US13496958

    申请日：2010-09-21

    Applicant: Philip Jones ,  Jesus Maria Ontoria Ontoria

    Inventor： Philip Jones ,  Jesus Maria Ontoria Ontoria

    IPC: C07D417/14 ,  A61P35/02 ,  A61P35/00 ,  C07D413/14 ,  A61K31/496

    CPC classification number: C07D413/04 ,  C07D417/04

    Abstract: The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.

    Abstract translation: 本发明涉及作为Sonic Hedgehog途径的抑制剂，特别是Smo拮抗剂的式（I）化合物及其药学上可接受的盐或互变异构体。 因此，本发明的化合物可用于治疗与异常hedgehog途径活化相关的疾病，包括癌症，例如基底细胞癌，成神经管细胞瘤，前列腺，胰腺癌，乳腺癌，结肠癌，骨细胞和小细胞肺癌，以及癌症 上胃肠道

    Radio receiver in a wireless communications system
    36.
    发明授权
    Radio receiver in a wireless communications system 有权
    无线电接收机在无线通信系统中

    公开(公告)号：US08189653B2

    公开(公告)日：2012-05-29

    申请号：US12016640

    申请日：2008-01-18

    Applicant: Carlo Luschi ,  Simon Huckett ,  Simon Walker ,  Steve Allpress ,  Philip Jones

    Inventor： Carlo Luschi ,  Simon Huckett ,  Simon Walker ,  Steve Allpress ,  Philip Jones

    IPC: H03H7/30

    CPC classification number: H04L25/03114 ,  H04B2201/7071 ,  H04L25/0212 ,  H04L2025/03566 ,  H04L2025/03726

    Abstract: Techniques are described for optimizing processing facilities of a receiver in a wireless communication environment, taking into consideration processing performance set against the computing resources and/or power consumption required to obtain the processing performance. An embodiment of a radio receiver is described that includes a channel equalization means arranged to receive digital samples of an incoming signal and to generate an equalized output, said channel equalization means including means for processing said digital samples in accordance with an equalizer algorithm utilizing a set of equalizer parameters. The receiver can include means for estimating at least one parameter of a channel over which the signal has been received, and means for selecting at least one of said equalizer parameters based on at least one of said estimated channel parameters. Related methods, algorithms, and computer program products are also described.

    Abstract translation: 描述了在无线通信环境中优化接收机的处理设施的技术，考虑到针对获得处理性能所需的计算资源和/或功耗设置的处理性能。 描述了一种无线电接收机的实施例，其包括信道均衡装置，其被配置为接收输入信号的数字样本并产生均衡的输出，所述信道均衡装置包括用于根据利用集合的均衡器算法处理所述数字样本的装置 均衡器参数。 接收机可以包括用于估计已经在其上接收信号的信道的至少一个参数的装置，以及用于基于所述估计的信道参数中的至少一个来选择所述均衡器参数中的至少一个的装置。 还描述了相关方法，算法和计算机程序产品。

    ELECTROKINETIC BELT PRESS APPARATUS AND A BELT THEREFOR
    37.
    发明申请
    ELECTROKINETIC BELT PRESS APPARATUS AND A BELT THEREFOR 审中-公开
    电动皮带压装置及其皮带

    公开(公告)号：US20120097599A1

    公开(公告)日：2012-04-26

    申请号：US13379514

    申请日：2010-06-21

    Applicant: Colin John Francis Philip Jones ,  John Lamont-Black

    Inventor： Colin John Francis Philip Jones ,  John Lamont-Black

    IPC: B01D33/04

    CPC classification number: B01D33/042 ,  B01D35/06 ,  B03C9/00 ,  B03C11/00 ,  B03C2201/02 ,  C02F1/4698 ,  C02F11/123

    Abstract: A belt (10) for an electrokinetic belt press (100) comprises a woven material, and having an electrical transfer zone (18) extending longitudinally along the belt (10) between a filtration zone (12) and an edge (22) of the belt (10), the electrical transfer zone (18) comprising a plurality of electrically-conducting warp elements arranged as a plurality of substantially parallel stripes (26), wherein adjacent stripes (26) are separated from each other in the transverse direction by at least one electrically-insulating warp element (28). The stripes (26) may be discontinuous in order to electrically isolate discrete conducting zones (14) of the filtration zone (14), the discontinuities being displaced longitudinally from each other. Also, an electrokinetic belt press apparatus (100) is described, comprising a pair of filtration belts (110, 111), at least one of which comprises a plurality of discrete conducting areas (14). A plurality of independent power supplies (P1-P6) are connected between contact elements (120, 121) for contacting the filtration belts (110, 111). The apparatus (100) further includes means (240, 250, 251) for applying a reverse polarity to one of the belts to de-cake the belt, and means (260, 270, 280, 290) for recirculating filtrate from the distal end (190) of a dewatering section (170) of the apparatus to the proximal end (180).

    Abstract translation: 用于电动带式压榨机（100）的带（10）包括织造材料，并且具有沿着带（10）在过滤区域（12）和边缘（22）之间纵向延伸的电转移区域（18） 带（10），所述电传递区（18）包括布置成多个基本上平行的条（26）的多个导电经向元件，其中相邻的条（26）在横向方向上彼此分开， 至少一个电绝缘翘曲元件（28）。 条纹（26）可以是不连续的，以便电隔离过滤区域（14）的离散导电区域（14），该不连续部分彼此纵向移位。 此外，描述了一种电动皮带加压装置（100），其包括一对过滤带（110,111），其中至少一个包括多个离散导电区域（14）。 多个独立电源（P1-P6）连接在用于接触过滤带（110,111）的接触元件（120,121）之间。 装置（100）还包括用于向其中一个皮带施加相反极性以去除皮带的装置（240,250,251），以及用于将滤液从远端再循环的装置（260,270,280,290） （190）的装置的脱水部分（170）到近端（180）。

    Dewatering treatment system and method
    38.
    发明授权
    Dewatering treatment system and method 有权
    脱水处理系统及方法

    公开(公告)号：US07943031B2

    公开(公告)日：2011-05-17

    申请号：US10574303

    申请日：2004-10-01

    Applicant: Colin John Francis Philip Jones ,  John Lamont-Black ,  Stephanie Glendinning

    Inventor： Colin John Francis Philip Jones ,  John Lamont-Black ,  Stephanie Glendinning

    IPC: B01D57/02

    CPC classification number: C02F11/123 ,  B01D35/06 ,  C02F1/469 ,  C02F1/4698 ,  C02F2001/46138 ,  C02F2001/46152 ,  C02F2103/10

    Abstract: An apparatus and method for reducing the liquid content of a particulate/liquid dispersion, such as a sewage sludge or mine tailings, are described. The apparatus comprises containment means to contain the material, and means to apply pressure to the contained material therein, the containment means being partly defined by a first filtration membrane permeable to the liquid but impermeable to at least some and more preferably substantially all of the solids contained within the material, in particular configured as a continuous belt press. The filtration membrane comprises a textile or other synthetic material in intimate association with a conducting element so as to constitute where so associated a first electrode. A second sheet material, preferably also a filtration membrane, is similarly associated with a conducting element so as to constitute a second electrode to allow application of a potential difference across the material and drive the dewatering process electrokinetically. Preferably, the apparatus is a belt filter press, and includes means to apply a variable and intermittent voltage to, and insulate from each other, two electrodes configured a continuously moving belts.

    Abstract translation: 描述了用于降低颗粒/液体分散体如污泥或矿尾矿液体含量的装置和方法。 所述装置包括容纳所述材料的容纳装置以及向其中所容纳的材料施加压力的装置，所述容纳装置部分地由可渗透液体的第一过滤膜限定，但至少部分且更优选基本上全部的固体不可渗透 容纳在材料内，特别是构造成连续带式压榨机。 过滤膜包括与导电元件紧密结合的织物或其它合成材料，以便构成第一电极的位置。 第二片材料，优选也是过滤膜，类似地与导电元件相关联，以便构成第二电极，以允许跨材料施加电位差并电动驱动脱水过程。 优选地，该设备是带式压滤机，并且包括将可变间歇电压施加并且彼此绝缘的装置，所述两个电极构造成连续移动的带。

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