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52 条记录 (耗时 0.057 秒)

    COMPOSITIONS AND METHODS FOR SILENCING SMAD4
    31.
    发明申请
    COMPOSITIONS AND METHODS FOR SILENCING SMAD4 有权
    用于沉默SMAD4的组合物和方法

    公开(公告)号：US20130172405A1

    公开(公告)日：2013-07-04

    申请号：US13725796

    申请日：2012-12-21

    申请人： PROTIVA BIOTHERAPEUTICS INC.

    发明人： Ammen P. Dhillon ,  Amy C.H. Lee ,  Ian MacLachlan

    IPC分类号： C07H21/02 ,  A61K48/00

    CPC分类号： C07H21/02 ,  A61K31/7105 ,  A61K31/713

    摘要： The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target SMAD4 gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for treating anemia of inflammation in humans).

    摘要翻译： 本发明提供了包含靶向SMAD4基因表达的治疗性核酸例如干扰RNA（例如dsRNA例如siRNA）的组合物，包含治疗性核酸的一种或多种（例如混合物）的脂质颗粒，制备该脂质的方法 颗粒和递送和/或施用脂质颗粒的方法（例如，用于治疗人类的炎症性贫血）。

    COMPOSITIONS AND METHODS FOR SILENCING EBOLA VIRUS GENE EXPRESSION
    40.
    发明申请
    COMPOSITIONS AND METHODS FOR SILENCING EBOLA VIRUS GENE EXPRESSION 审中-公开
    用于沉默EBOLA病毒基因表达的组合物和方法

    公开(公告)号：US20150111945A1

    公开(公告)日：2015-04-23

    申请号：US14229675

    申请日：2014-03-28

    申请人： Protiva Biotherapeutics, Inc. ,  Trustees of Boston University ,  United States Army Medical Research and Materiel Command

    发明人： Thomas W. Geisbert ,  Amy C.H. Lee ,  Marjorie Robbins ,  Vandana Sood ,  Adam Judge ,  Lisa E. Hensley ,  Ian MacLachlan

    IPC分类号： C12N15/113 ,  A61K9/127 ,  A61K31/713

    CPC分类号： C12N15/1131 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/713 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2320/31 ,  C12N2330/51 ,  C12N2760/14111 ,  C12N2310/3521

    摘要： The present invention provides compositions comprising therapeutic nucleic acids (e.g., interfering RNA such as siRNA) that target Ebola virus (EBOV) gene expression and methods of using such compositions to silence EBOV gene expression. More particularly, the invention provides unmodified and chemically modified interfering RNA which silence EBOV gene expression and methods of use thereof, e.g., for preventing or treating EBOV infections caused by one or more EBOV species such as Zaire EBOV. The invention also provides serum-stable nucleic acid-lipid particles comprising one or more interfering RNA molecules, a cationic lipid, and a non-cationic lipid, which can further comprise a conjugated lipid that inhibits aggregation of particles. Methods of silencing EBOV gene expression by administering one or more interfering RNA molecules to a mammalian subject are also provided.

    摘要翻译： 本发明提供包含针对埃博拉病毒（EBOV）基因表达的治疗性核酸（例如干扰RNA（例如siRNA））和使用这种组合物沉默EBOV基因表达的方法的组合物。 更具体地说，本发明提供了沉默EBOV基因表达的未修饰和化学修饰的干扰RNA及其使用方法，例如用于预防或治疗由一种或多种EBOV物种如扎伊尔EBOV引起的EBOV感染。 本发明还提供包含一种或多种干扰RNA分子，阳离子脂质和非阳离子脂质的血清稳定核酸 - 脂质颗粒，其可以进一步包含抑制颗粒聚集的共轭脂质。 还提供了通过向哺乳动物受试者施用一种或多种干扰RNA分子使EBOV基因表达沉默的方法。