公开(公告)号：US20160230230A1

公开(公告)日：2016-08-11

申请号：US15024997

申请日：2014-09-26

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  UNIVERSITÉ DE VERSAILLES SAINT-QUENTIN-EN-YVELINES ,  ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)

发明人： Eric Ogier-Denis ,  Yannick Ladeiro ,  Xavier Treton ,  Yoram Bouhnik ,  Yong-Ping Ding

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2561/113 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention relates to methods and kits for diagnosing ulcerative colitis in a subject. In particular, the present invention relates to a method for diagnosing ulcerative colitis in a subject comprising the steps consisting of determining in a sample obtained from the subject the expression level of at least one gene selected from the group consisting of ADH4, ADH6, ADHFE1, AKR1A1, AKR7A2, ALDH1A3, ALDH1L1, ALDH7A1, AOX1, BCHE, CBR3, CES1, CYP1B1, CYP2E1, CYP2W1, CYP4F11, CYP51A1, ESD, KCNAB2, COMT, GSTA4, GSTP1, INMT, MGST2, SULT2A1, TPMT, UGT1A4, UGT1A9, UGT2B7, ABCA1, ABCA2, ABCB1, ABCC1, ABCC10, ABCC5, ABCC6, ABCG2, ATP7A, SLC1A3, SLC7A5, SLC10A2, SLC15A1, SLC15A2, SLC19A2, SLC19A3, SLC22A3, SLC28A3, SLC29A2, SLC38A1, SLC38A5, SLC47A1, SLCO2B1, SLCO4C1, ARNT, FOXO1, HIF3A, NCOA2, NCOR2, NR1H3, NR3C1, PPARD, PPARGC1A, RARB, RXRB, and THRB.

摘要翻译： 本发明涉及用于诊断受试者的溃疡性结肠炎的方法和试剂盒。 特别地，本发明涉及一种用于诊断受试者的溃疡性结肠炎的方法，包括以下步骤：在从受试者获得的样品中测定至少一种选自ADH4，ADH6，ADHFE1， AKT1A1，TP1T3，AKR7A2，ALDH1A3，ALDH1L1，ALDH7A1，AOX1，BCHE，CBR3，CES1，CYP1B1，CYP2E1，CYP2W1，CYP4F11，CYP51A1，ESD，KCNAB2，COMT，GSTA4，GSTP1，INMT，MGST2，SULT2A1，TPMT，UGT1A4，UGT1A9， UGT2B7，ABCA1，ABCA2，ABCB1，ABCC1，ABCC10，ABCC5，ABCC6，ABCG2，ATP7A，SLC1A3，SLC7A5，SLC10A2，SLC15A1，SLC15A2，SLC19A2，SLC19A3，SLC22A3，SLC28A3，SLC29A2，SLC38A1，SLC38A5，SLC47A1，SLCO2B1，SLCO4C1， ARNT，FOXO1，HIF3A，NCOA2，NCOR2，NR1H3，NR3C1，PPARD，PPARGC1A，RARB，RXRB和THRB。

公开(公告)号：US20160123982A1

公开(公告)日：2016-05-05

申请号：US14765631

申请日：2014-02-04

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE (INTS) ,  UNIVERSITE DES ANTILLES ET DE LA GUYANE

发明人： Wassim EL NEMER ,  Maria DE GRANDIS

IPC分类号： G01N33/573

CPC分类号： G01N33/573 ,  G01N33/5044 ,  G01N33/574 ,  G01N33/57426 ,  G01N2333/78 ,  G01N2333/912 ,  G01N2333/91215 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2800/22 ,  G01N2800/52 ,  G01N2800/7023

摘要： The present invention relates to methods for assaying JAK2 activity in a red blood cell. The present invention also relates to methods for diagnosing myeloproliferative neoplasm.

摘要翻译： 本发明涉及测定红细胞中JAK2活性的方法。 本发明还涉及骨髓增生性肿瘤的诊断方法。

公开(公告)号：US11508261B2

公开(公告)日：2022-11-22

申请号：US15761486

申请日：2016-09-23

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  SORBONNE UNIVERSITÉ ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Thomas Deffieux ,  Mickaël Tanter ,  Jean-Luc Gennisson ,  Zsolt Lenkei ,  Mathieu Pernot

IPC分类号： G09B23/28 ,  A61B8/08 ,  A61B8/00 ,  G16H50/50 ,  A61B8/06 ,  G06T7/00

摘要： The invention relates to a method for obtaining a numerical model, the numerical model associating at least one objective measurement to a subjective sensation, the method comprising the steps of: a) imaging the at least one area of the brain by using unfocused waves produced by a transcranial ultrasound probe (20), to obtain at least one acquired image of the activity of the area, b) evaluating a physical quantity representative of the activity of the at least one area based on the acquired images, to obtain at least one objective measurement, c) obtaining from the subject at least one numerical value representative of a subjective sensation, and d) determining the numerical model by using the obtained objective measurement and the obtained numerical value.

公开(公告)号：US11234677B2

公开(公告)日：2022-02-01

申请号：US15580026

申请日：2016-06-09

申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Centre national de la recherche scientifique ,  Université Pierre et Marie Curie (Paris 6) ,  Université Paris Diderot—Paris 7 ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Jean-Luc Gennisson ,  Mickaël Tanter ,  Thomas Deffieux ,  Mathieu Pernot

IPC分类号： A61B8/00 ,  A61B8/06 ,  A61B5/11 ,  A61B8/08 ,  A61B5/24 ,  A61B5/291

摘要： The invention concerns a detecting apparatus (12) comprising:—at least two sensors (24, 26, 28), with at least one sensor (24) being an ultrasound transducer adapted to produce ultrasound waves, and—a positioning device (16) defining several compartments (22), each compartment (22) being adapted to hold a sensor (24, 26, 28) and each compartment (22) being located at predetermined location, the positioning device (16) comprising a holder adapted to be fixed on the skull of a subject, the positioning device (16) being adapted to be maintained on the head of the subject using the holder.

公开(公告)号：US10974080B2

公开(公告)日：2021-04-13

申请号：US15899076

申请日：2018-02-19

申请人： CARDIAWAVE ,  Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS- ,  Université Paris Diderot—Paris 7

发明人： Mickaël Tanter ,  Mathieu Pernot ,  Justine Robin

IPC分类号： A61N7/02 ,  A61N7/00 ,  A61B8/00 ,  A61B17/22 ,  A61B8/08 ,  A61B17/00

摘要： A method and system for secure ultrasound treatment of living tissues using an ultrasound probe comprising a reflective cavity in acoustic communication with living tissues, a transducer to emit an ultrasound wave in the reflective cavity and a transducer to acquire a backscattered signal in the reflective cavity. The method comprises the steps of a) emitting a first ultrasound wave in the reflective cavity that generates a backscattered ultrasound wave in the reflective cavity, b) acquiring a backscattered signal in the reflective cavity, c) determining whether an insonification can be safely performed by computing a similarity value between the backscattered signal and a predefined reference signal, and d) if an insonification can be safely performed, treating the living tissues with a second ultrasound wave emitted in the reflective cavity. The second ultrasound wave is focused a target point of the living tissues and generates a pressure point resulting in cavitation at this target point.

公开(公告)号：US10952701B2

公开(公告)日：2021-03-23

申请号：US15735759

申请日：2016-06-16

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITÉ PARIS DIDEROT—PARIS 7 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Thomas Deffieux ,  Jean-Luc Gennisson ,  Mickaël Tanter ,  Ivan Cohen ,  Mathieu Pernot

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61B8/14 ,  A61B5/00 ,  A61B5/0478

摘要： The invention concerns a detecting apparatus (12) for imaging at least two areas of a brain of a subject (10), the detecting apparatus (12) comprising: —a holder comprising: —a frame (14) devoted to be cemented on the skull of the subject (10), the frame (14) delimitating an inner portion (18) which is transparent to ultrasound waves, —a removable imaging device comprising: —a platform (16) delimitating an inner space (28), the inner space (28) facing the inner portion (18), —a fixing element (30) adapted to temporary fix and lock the platform (16) to the holder, —an ultrasound probe (32), and —a moving stage (34) holding the ultrasound probe (32) and being adapted to move the ultrasound probe (32) within the inner space (28).

公开(公告)号：US10881380B2

公开(公告)日：2021-01-05

申请号：US15325103

申请日：2015-07-17

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITÉ PARIS DIDEROT—PARIS 7 ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Mickael Tanter ,  Mathieu Pernot

IPC分类号： A61B8/08 ,  G01S7/52 ,  A61B8/00

摘要： The present invention concerns a method for obtaining a functional parameter of a muscle having a part, the method comprising the steps of: a) applying ultrasound waves to the muscle, b) collecting the ultrasound waves retrodiffused by the muscle at a plurality of times, to obtain collected ultrasound waves, c) determining a first plurality of values representative of stiffness values of one part at a first plurality of times by using the collected ultrasound waves, d) determining a second plurality of values representative of deformation values of said part at a second plurality of times by using the collected ultrasound waves, and e) deducing at least one functional parameter based on the first plurality of values and the second plurality of values. The invention also concerns a corresponding device.

公开(公告)号：US20200048342A1

公开(公告)日：2020-02-13

申请号：US16519683

申请日：2019-07-23

申请人： INSERM ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7

发明人： Anne Joutel ,  Søren Christensen ,  Thorleif Jan Pedersen

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K39/00

摘要： The present invention relates to an anti-Notch 3 antibody therapy useful for treatment of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. In particular, the invention relates to an anti-Notch3 antibody or a fragment thereof having a 2 fold, 4 fold or 10 fold higher affinity to Notch 3 than to Notch 1 or Notch 2 for use in therapy.

公开(公告)号：US20190275195A1

公开(公告)日：2019-09-12

申请号：US16371235

申请日：2019-04-01

申请人： INSERM (Institut de la Santé et de la Recherche Médicale) ,  Université Paris Diderot - Paris 7 ,  Centre National de la Recherche Scientifique (CNRS) ,  Université Paris XIII Paris-Nord ,  École Supérieur de Physique et de Chimie Industrielles de Paris

发明人： Ludwik LEIBLER ,  Anne MEDDAHI-PELLÉ ,  Didier LETOURNEUR ,  Alba MARCELLAN-PARISOT

IPC分类号： A61L24/00 ,  A61L26/00 ,  A61L24/02 ,  A61L24/08

摘要： The present invention relates to methods for adhering tissue surfaces and materials and biomedical uses thereof. In particular the present invention relates to a method for adhering a first tissue surface to a second tissue surface in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on at least one of the tissue surfaces, and approximating the surfaces for a time sufficient for allowing the surfaces to adhere to each other. The present invention also relates to a method for adhering a material to a biological tissue in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on the surface of the material and/or the biological tissue and approximating the material and the biological tissue for a time sufficient for allowing the material and the biological tissue to adhere to each other.

公开(公告)号：US20190219655A1

公开(公告)日：2019-07-18

申请号：US16332321

申请日：2017-09-13

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ASSISTANCE PUBLIQUE ? HÔPITAUX DE PARIS

发明人： Benjamin LEPORQ ,  Jean - Luc DAIRE ,  Bernard VAN BEERS

IPC分类号： G01R33/565 ,  G01R33/56 ,  A61B5/055 ,  A61B5/00 ,  G06T7/70 ,  G06T7/00

CPC分类号： G01R33/56509 ,  A61B5/055 ,  A61B5/7207 ,  G01R33/5601 ,  G01R33/5608 ,  G06T7/0014 ,  G06T7/70 ,  G06T2207/10088 ,  G06T2207/30056 ,  G06T2207/30061

摘要： Disclosed is the use of magnetic resonance imaging in the medical field. One issue addressed is the compensating of respiratory movements in the obtained images with magnetic resonance imaging. For this, the method proposes to choose a reference image in the initial set, the determined position for the reference image being a reference position and to compensate the difference between the determined position and the reference position to obtain a corrected set of images for each image of the initial set. Such method can be implemented in a computer and may be used to provide additional functionalities to magnetic resonance imager and renders the taking of images by a magnetic resonance imager easier.