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公开(公告)号：US08428679B2
公开(公告)日：2013-04-23
申请号：US12748144
申请日：2010-03-26
IPC分类号： A61B5/05
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14542 , A61B5/14865 , A61B2560/0223 , G06F19/00
摘要： Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.
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公开(公告)号：US08290562B2
公开(公告)日：2012-10-16
申请号：US12772842
申请日：2010-05-03
IPC分类号： A61B5/05
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14542 , A61B5/14865 , A61B2560/0223 , G06F19/00
摘要： Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.
摘要翻译： 用于处理传感器分析数据的系统和方法，包括启动校准，更新校准，评估参考和传感器分析数据的临床可接受性，以及评估传感器校准的质量。 在初始校准期间，在一段时间内评估分析物传感器数据，以确定传感器的稳定性。 可以使用一个或多个匹配的传感器和参考分析物数据对的校准集来校准传感器。 基于新收到的参考分析物数据的纳入标准，可以在评估用于最佳校准的校准集之后更新校准。 基于参考和分析物数据的临床可接受性和传感器校准的质量提供故障安全机制。 算法提供了来自分析物传感器的估计血液分析物数据的优化前瞻性和回顾性分析。
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公开(公告)号：US08282549B2
公开(公告)日：2012-10-09
申请号：US11007920
申请日：2004-12-08
申请人： James H. Brauker , Victoria Carr-Brendel , Paul V. Goode , Apurv U. Kamath , James P. Thrower , Ben Xavier
发明人： James H. Brauker , Victoria Carr-Brendel , Paul V. Goode , Apurv U. Kamath , James P. Thrower , Ben Xavier
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/145 , A61B5/14503 , A61B5/1451 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B5/7275 , A61B5/742 , A61B5/7455 , A61B5/746 , A61B5/7475 , A61M5/1723 , G06F19/00 , Y02A90/22 , Y02A90/26
摘要： A second numerical value 246 is shown, which is representative of a variation of the measured analyte value 242. The second numerical value is preferably determined from a variation analysis based on statistical, clinical, or physiological parameters, such as described in more detail elsewhere herein. In one embodiment, the second numerical value 246 is determined based on clinical risk (for example, weighted for the greatest possible clinical risk to a patient). In another embodiment, the second numerical representation 246 is an estimated analyte value extrapolated to compensate for a time lag, such as described in more detail elsewhere herein. In some alternative embodiments, the receiver displays a range of numerical analyte values that best represents the host's estimated analyte value (for example, +/−10%). In some embodiments, the range is weighted based on clinical risk to the patient. In some embodiments, the range is representative of a confidence in the estimated analyte value and/or a variation of those values. In some embodiments, the range is adjustable.
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公开(公告)号：US08251906B2
公开(公告)日：2012-08-28
申请号：US12424403
申请日：2009-04-15
申请人： James H. Brauker , Victoria Carr-Brendel , Paul V. Goode , Apurv U. Kamath , James P. Thrower , Ben Xavier
发明人： James H. Brauker , Victoria Carr-Brendel , Paul V. Goode , Apurv U. Kamath , James P. Thrower , Ben Xavier
CPC分类号： A61B5/14532 , A61B5/145 , A61B5/14503 , A61B5/1451 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B5/7275 , A61B5/742 , A61B5/7455 , A61B5/746 , A61B5/7475 , A61M5/1723 , G06F19/00 , Y02A90/22 , Y02A90/26
摘要： Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.
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公开(公告)号：US08128562B2
公开(公告)日：2012-03-06
申请号：US12579392
申请日：2009-10-14
申请人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
发明人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
IPC分类号： A61B5/05
CPC分类号： A61B5/7203 , A61B5/0004 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/7225 , A61B5/7257 , A61B5/726 , A61B5/7278 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2562/0247 , A61B2562/0271 , A61B2562/08
摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
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公开(公告)号：US20110275919A1
公开(公告)日：2011-11-10
申请号：US13187277
申请日：2011-07-20
IPC分类号： A61B5/1468
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译： 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。
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公开(公告)号：US20110263958A1
公开(公告)日：2011-10-27
申请号：US13175392
申请日：2011-07-01
申请人： James H. Brauker , Victoria Carr-Brendel , Paul V. Goode , Apurv U. Kamath , James P. Thrower , Ben Xavier
发明人： James H. Brauker , Victoria Carr-Brendel , Paul V. Goode , Apurv U. Kamath , James P. Thrower , Ben Xavier
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/145 , A61B5/14503 , A61B5/1451 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B5/7275 , A61B5/742 , A61B5/7455 , A61B5/746 , A61B5/7475 , A61M5/1723 , G06F19/00 , Y02A90/22 , Y02A90/26
摘要： Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.
摘要翻译： 用于动态和智能地估计来自连续分析物传感器的分析物数据的系统和方法，包括接收数据流，选择多种算法中的一种，以及采用所选择的算法来估计分析物值。 附加数据处理包括评估所选择的估计算法，基于统计学，临床或生理参数分析估计分析物值的变化，将估计的分析物值与相应的测量分析物值进行比较，以及向用户提供输出。 估计可用于补偿时间滞后，匹配传感器数据与相应的参考数据，警告即将到来的临床风险，替换错误的传感器数据信号，并提供更及时的分析物信息，鼓励主动行为和抢占临床风险。
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公开(公告)号：US07998071B2
公开(公告)日：2011-08-16
申请号：US12579339
申请日：2009-10-14
申请人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
发明人： Paul V. Goode, Jr. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
CPC分类号： A61B5/7203 , A61B5/0004 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/7225 , A61B5/7257 , A61B5/726 , A61B5/7278 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2562/0247 , A61B2562/0271 , A61B2562/08
摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
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公开(公告)号：US07979104B2
公开(公告)日：2011-07-12
申请号：US12788125
申请日：2010-05-26
IPC分类号： A61B5/05
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14542 , A61B5/14865 , A61B2560/0223 , G06F19/00
摘要： Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.
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公开(公告)号：US20110137601A1
公开(公告)日：2011-06-09
申请号：US13023835
申请日：2011-02-09
申请人： Paul V. Goode, JR. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
发明人： Paul V. Goode, JR. , James H. Brauker , Apurv U. Kamath , James Patrick Thrower , Victoria Carr-Brendel
CPC分类号： A61B5/7203 , A61B5/0004 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/7225 , A61B5/7257 , A61B5/726 , A61B5/7278 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2562/0247 , A61B2562/0271 , A61B2562/08
摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
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