公开(公告)号：US20240307382A1

公开(公告)日：2024-09-19

申请号：US18330185

申请日：2023-06-06

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Kathleen Ann Martin ,  Carmela Sidrauski ,  Jennifer M. Frost ,  Marina Pliushchev ,  Yunsong Tong ,  Lawrence A. Black ,  Xiangdong Xu ,  Lei Shi ,  Qingwei Zhang ,  SeungWon Chung ,  Ramzi Farah Sweis ,  Michael J. Dart ,  John T. Randolph ,  Kathleen J. Murauski

IPC: A61K31/4965 ,  A61K31/196 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/472 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5355 ,  A61K45/06 ,  C07C233/62 ,  C07D217/26 ,  C07D231/14 ,  C07D237/20 ,  C07D241/20 ,  C07D249/10 ,  C07D261/18 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68 ,  C07D317/46 ,  C07D333/38 ,  C07D401/04 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

CPC classification number: A61K31/4965 ,  A61K31/196 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/472 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5355 ,  A61K45/06 ,  C07C233/62 ,  C07D217/26 ,  C07D231/14 ,  C07D237/20 ,  C07D241/20 ,  C07D249/10 ,  C07D261/18 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68 ,  C07D317/46 ,  C07D333/38 ,  C07D401/04 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US20240166652A1

公开(公告)日：2024-05-23

申请号：US18324901

申请日：2023-05-26

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Kathleen Ann Martin ,  Carmela Sidrauski ,  Marina Pliushchev ,  Jennifer M. Frost ,  Yunsong Tong ,  Lawrence A. Black ,  Xiangdong Xu ,  Lei Shi ,  Qingwei Zhang ,  SeungWon Chung ,  Zhaoming Xiong ,  Ramzi Farah Sweis ,  Michael J. Dart ,  Brian S. Brown ,  Kathleen J. Murauski

IPC: C07D487/04 ,  C07C235/22 ,  C07D213/30 ,  C07D213/643 ,  C07D213/73 ,  C07D231/56 ,  C07D241/18 ,  C07D261/20 ,  C07D271/07 ,  C07D271/113

CPC classification number: C07D487/04 ,  C07C235/22 ,  C07D213/30 ,  C07D213/643 ,  C07D213/73 ,  C07D231/56 ,  C07D241/18 ,  C07D261/20 ,  C07D271/07 ,  C07D271/113

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US20210363136A1

公开(公告)日：2021-11-25

申请号：US16863737

申请日：2020-04-30

Applicant: Calico Life Sciences LLC ,  AbbVie Inc. ,  SYGNATURE DISCOVERY LIMITED

Inventor： Kathleen Ann Martin ,  Carmela Sidrauski ,  Jennifer M. Frost ,  Yunsong Tong ,  Xiangdong Xu ,  SeungWon Chung ,  Qingwei I Zhang ,  Lei Shi ,  Kathleen J. Murauski ,  Michael J. Dart ,  John T. Randolph ,  Hanae Benelkebir

IPC: C07D413/12 ,  C07D317/68 ,  C07D311/24 ,  C07D209/08 ,  C07D265/36 ,  C07D307/83 ,  C07D307/85 ,  C07D319/20 ,  C07D493/04 ,  C07D405/12 ,  C07D417/12 ,  C07D493/08 ,  C07D405/14

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：US20210113532A1

公开(公告)日：2021-04-22

申请号：US16885766

申请日：2020-05-28

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Carmela Sidrauski ,  Marina Pliushchev ,  Jennifer M. Frost ,  Lawrence A. Black ,  Xiangdong Xu ,  Ramzi Farah Sweis ,  Lei Shi ,  Qingwei I. Zhang ,  Yunsong Tong ,  Charles W. Hutchins ,  SeungWon Chung ,  Michael J. Dart

IPC: A61K31/42 ,  C07D271/10 ,  C07D471/04 ,  C07D271/06 ,  C07D401/12 ,  C07D233/64 ,  C07D413/12 ,  A61P3/08 ,  A61P25/28 ,  A61P9/00 ,  A61P35/00

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US20190144440A1

公开(公告)日：2019-05-16

申请号：US16098675

申请日：2017-05-05

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Carmela Sidrauski ,  Marina Pliushchev ,  Jennifer M. Frost ,  Lawrence A. Black ,  Xiangdong Xu ,  Ramzi Farah Sweis ,  Lei Shi ,  Qingwei I. Zhang ,  Yunsong Tong ,  Charles W. Hutchins ,  Seungwon Chung ,  Michael J. Dart

IPC: C07D471/04 ,  A61P25/28 ,  C07D213/30 ,  C07D213/64 ,  C07D213/66 ,  C07D213/73 ,  C07D231/56 ,  C07D241/18 ,  C07D261/08 ,  C07D271/113 ,  C07D261/20 ,  C07D317/64 ,  C07D401/04 ,  C07D405/08

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US20190135836A1

公开(公告)日：2019-05-09

申请号：US16230408

申请日：2018-12-21

Applicant: AbbVie Inc.

Inventor： Michael Friedman ,  Phil Cox ,  Kristine E. Frank ,  Michael Z. Hoemann ,  Augustine Osuma ,  Noel S. Wilson ,  Xiangdong Xu ,  Kevin Cusack ,  Raymond Huntley ,  J. Martin Herold

IPC: C07D519/00 ,  A61K31/437 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: This invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers, and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.