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公开(公告)号:US20090258933A1
公开(公告)日:2009-10-15
申请号:US12486703
申请日:2009-06-17
申请人: Shunichiro KUBOTA , Masaaki Terada , Takahiro Ochiya , Hiroshi Itoh , Masayasu Furuse , Akihiko Sano , Shunji Nagahara
发明人: Shunichiro KUBOTA , Masaaki Terada , Takahiro Ochiya , Hiroshi Itoh , Masayasu Furuse , Akihiko Sano , Shunji Nagahara
IPC分类号: A61K31/7088
CPC分类号: A61K9/0024 , A61K9/0019 , A61K9/127 , A61K9/19 , A61K9/2063 , A61K9/7007 , A61K31/7105 , A61K31/711 , A61K47/42 , A61K48/00 , A61K48/0008
摘要: Preparations for transferring efficiently oligonucleotides necessary in antisense therapy or the like into animal cells so as to be useful in treatment for various diseases, which comprises a collagen as an essential component are provided.
摘要翻译: 提供将反义治疗等中必需的寡核苷酸有效转移到动物细胞中以便可用于治疗包括胶原蛋白作为必需成分的各种疾病的制剂。
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公开(公告)号:US20080067216A1
公开(公告)日:2008-03-20
申请号:US11900747
申请日:2007-09-13
申请人: Akihiko Sano , Yoshitaka Miura
发明人: Akihiko Sano , Yoshitaka Miura
IPC分类号: B23K20/12
CPC分类号: B23K20/126 , B23K20/1225 , B23K33/00 , F16H41/24 , F16H41/28 , F16H2041/243
摘要: A bonding structure for a container member is disclosed. The container member has an opening and a covering member for covering the opening. The container member and covering member are abutted with each other and bonded by a friction stir welding operation. The bonding structure for the container and covering members comprises a bonding portion and a backing member. The bonding portion of the container member and the covering member is formed by inserting a friction stir welding tool into an abutting portion of the container member and the covering member. The backing member is provided for obstructing a plastic flow of materials for the container member and the covering member when the friction stir welding operation is performed. The backing member is disposed adjacent to the bonding portion, at a side of the abutting portion that is opposite to an inserting side of the friction stir welding tool.
摘要翻译: 公开了一种用于容器构件的接合结构。 容器构件具有用于覆盖开口的开口和覆盖构件。 容器构件和覆盖构件彼此抵接并通过摩擦搅拌焊接操作结合。 用于容器和覆盖构件的接合结构包括接合部分和背衬构件。 容器构件和覆盖构件的接合部分通过将摩擦搅拌焊接工具插入到容器构件和覆盖构件的邻接部分中而形成。 背衬构件被设置用于当执行摩擦搅拌焊接操作时阻挡用于容器构件和覆盖构件的材料的塑性流动。 背衬构件邻近结合部设置在与摩擦搅拌焊接工具的插入侧相对的抵接部的一侧。
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公开(公告)号:US20060140766A1
公开(公告)日:2006-06-29
申请号:US11022797
申请日:2004-12-28
申请人: Akihiko Sano , Yoshitaka Miura , Tsutomu Kamitani
发明人: Akihiko Sano , Yoshitaka Miura , Tsutomu Kamitani
IPC分类号: B63H1/16
CPC分类号: F16H41/26
摘要: A vane wheel for torque converter with a plurality of blades formed integrally with a shell in a casting process is disclosed. The blade tilts relative to an axial direction of the vane wheel and has an inner surface located on a positive pressure side thereof and an outer surface located on a negative pressure side thereof. A root thickness in a middle section between an outer periphery side and an inner periphery side of the shell is thicker than a root thickness on the inner periphery side relative to a blade cross section along a circumferential direction from an axis center of the vane wheel.
摘要翻译: 公开了一种用于变矩器的叶轮,其具有在铸造过程中与壳体一体形成的多个叶片。 叶片相对于叶轮的轴向倾斜,并且具有位于其正压侧的内表面和位于其负压侧的外表面。 壳体的外周侧和内周侧之间的中间部分的根部厚度比沿叶轮的轴心的圆周方向相对于叶片截面的内周侧的根部厚度厚。
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公开(公告)号:US07052875B1
公开(公告)日:2006-05-30
申请号:US09701013
申请日:1999-05-19
IPC分类号: C12P19/34 , A61K38/17 , C07H21/02 , C07C59/255 , C07C59/265
CPC分类号: A61K48/0025 , A61K48/0008 , A61K48/0091
摘要: The invention is directed to the retention of the stability of formulations useful for a gene therapy during the preparation and preservation. In the invention, at least one saccharide and/or at least one non-hydrophobic amino acid and/or at least one organic acid having two or more carboxyl groups except amino acids, or a collagen or a gelatin and at least one amino acid are added to a gene formulation.
摘要翻译: 本发明涉及在制备和保存期间保留用于基因治疗的制剂的稳定性。 在本发明中,至少一种糖和/或至少一种非疏水性氨基酸和/或至少一种除氨基酸以外具有两个或多个羧基的有机酸,或胶原或明胶和至少一种氨基酸 添加到基因制剂中。
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公开(公告)号:US4998451A
公开(公告)日:1991-03-12
申请号:US376287
申请日:1989-07-06
申请人: Akihiko Sano
发明人: Akihiko Sano
CPC分类号: F16H61/0437 , F16H61/0021 , F16H61/08 , F16H2061/0087 , F16H2061/0096 , F16H2061/0255 , Y10T477/6937 , Y10T477/69387 , Y10T477/69395 , Y10T477/693973
摘要: A line pressure control system features the use of a self-adjusting arrangement wherein the total shift time is determined and compared with a target time for the instant shift. The line pressure control duty cycle is modified until the line pressure level is adjusted in a manner which reduces the difference between the actual total shift time and the target value, to zero.
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公开(公告)号:US20110217366A1
公开(公告)日:2011-09-08
申请号:US13109949
申请日:2011-05-17
申请人: Keiji FUJIOKA , Akihiko Sano , Shunji Nagahara , Malcolm Roy Brandon , Andrew Donald Nash , Shari Lofthouse
发明人: Keiji FUJIOKA , Akihiko Sano , Shunji Nagahara , Malcolm Roy Brandon , Andrew Donald Nash , Shari Lofthouse
IPC分类号: A61K39/12 , A61K39/00 , A61K39/02 , A61K39/002 , A61K9/00 , A61K9/127 , C07K16/00 , A61P31/12 , A61P31/04 , A61P31/00 , A61P33/00 , A61P37/04
CPC分类号: A61K39/39 , A61K9/0024 , A61K9/0092 , A61K9/70 , A61K47/42
摘要: The present invention provides an immunopotentiating composition which comprises an antigen or antigen-inducing substance, and a carrier comprising a biocompatible material for effectively increasing an immune response derived from an antigen. The present invention further provides a method of producing an antibody by administering said immunopotentiating composition to a mammal or bird, thereby modulating the immune response in said mammal or bird and recovering the antibody produced.
摘要翻译: 本发明提供一种免疫增强组合物,其包含抗原或抗原诱导物质,和包含生物相容性物质的载体,用于有效增加源自抗原的免疫应答。 本发明进一步提供了通过向哺乳动物或鸟施用所述免疫增强组合物从而调节所述哺乳动物或鸟类中的免疫应答并回收产生的抗体来产生抗体的方法。
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公开(公告)号:US07601363B2
公开(公告)日:2009-10-13
申请号:US11688082
申请日:2007-03-19
申请人: Akihiko Sano , Masako Kajihara , Hiroo Maeda
发明人: Akihiko Sano , Masako Kajihara , Hiroo Maeda
CPC分类号: A61K9/0024 , A61K47/02
摘要: The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of combinations (a), (b) and (c), as well as a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed into the carrier: (a) particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which is reacted with the carbonate in an aqueous solution to generate carbon dioxide (substance such as an acid); (b) particles comprising an active ingredient and a carbonate, and particles comprising a substance such as an acid; and (c) particles comprising a carbonate, and particles comprising an active ingredient and a substance such as an acid.
摘要翻译: 本发明涉及具有实现活性成分控制释放的新颖结构的植入制剂。 制剂包含组合(a),(b)和(c)中的一种,以及包含疏水性聚合物的载体,其中所述颗粒组合分散在载体中:(a)包含活性成分的颗粒, 碳酸盐和包含与碳酸盐在水溶液中反应产生二氧化碳(物质如酸)的物质的颗粒; (b)包含活性成分和碳酸酯的颗粒,以及包含物质如酸的颗粒; 和(c)包含碳酸盐的颗粒和包含活性成分和物质如酸的颗粒。
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公开(公告)号:US20060045427A1
公开(公告)日:2006-03-02
申请号:US11214650
申请日:2005-08-30
申请人: Akihiko Sano , Shuichi Misumi , Eiichi Omura
发明人: Akihiko Sano , Shuichi Misumi , Eiichi Omura
IPC分类号: G02B6/30
CPC分类号: G02B6/138 , G02B6/2804 , G02B6/30 , G02B6/3636 , G02B6/3652 , G02B6/3692 , G02B6/3696
摘要: Optical fiber guides are provided outside a waveguide mounting region of a supporting substrate. Optical fibers are provided so as to be fitted in the optical fibers, respectively. In addition, end faces of the optical fibers and end faces to which a core of an optical waveguide is exposed are opposed and almost parallel to each other. Furthermore, the end face to which the core of the optical waveguide is exposed is provided so as to form an acute angle with a surface of the supporting substrate. Thus, tip ends of the optical fibers are not likely to be shifted from the core in a thickness direction of an optical waveguide device.
摘要翻译: 光纤引导件设置在支撑基板的波导安装区域的外侧。 光纤分别设置在光纤中。 此外,光纤的端面和光波导的芯部露出的端面相对并且几乎彼此平行。 此外,光波导的芯的露出端面设置成与支撑基板的表面形成锐角。 因此,光纤的末端在光波导装置的厚度方向上不易从芯部移位。
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公开(公告)号:US5922356A
公开(公告)日:1999-07-13
申请号:US947463
申请日:1997-10-09
申请人: Norimasa Koseki , Akihiko Sano
发明人: Norimasa Koseki , Akihiko Sano
CPC分类号: A61K9/205 , A61K9/2063
摘要: The present invention relates to a sustained release formulation used for treatment or prevention of the diseases, which contains a therapeutically effective substance as an active ingredient, collagen as a drug carrier, and glycosaminoglycan as an additive. The formulation allows controlled release of the therapeutically effective substance.
摘要翻译: 本发明涉及用于治疗或预防疾病的缓释制剂,其包含作为活性成分的治疗有效物质,作为药物载体的胶原蛋白和作为添加剂的糖胺聚糖。 制剂允许控制释放治疗有效物质。
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公开(公告)号:US5396421A
公开(公告)日:1995-03-07
申请号:US794220
申请日:1991-11-19
申请人: Yasuhiro Niikura , Tokiyoshi Yanai , Akihiko Sano
发明人: Yasuhiro Niikura , Tokiyoshi Yanai , Akihiko Sano
IPC分类号: B60K17/16 , B60K17/34 , B60K23/04 , F16D31/00 , F16D48/02 , F16D48/12 , F16H48/12 , F16H48/18 , F16H48/19 , F16H48/26 , F16H48/27 , F16H48/36 , F16H48/38 , B60K41/16
CPC分类号: B60K23/04
摘要: A torque distribution control device includes two rotational speed differential responsive type control couplings each having various transfer torque characteristics which differ in the ratio of a transfer torque to a rotational speed differential. The control device selects one of the torque transfer characteristics in response to a signal supplied thereto. When turning the outer wheel side control coupling is supplied with a signal for selecting the transfer torque characteristic that produces a maximum transfer torque for a given rotational speed differential, and the inner wheel side control coupling is supplied with a signal for attaining a non-slip rotational speed differential and for selecting the transfer torque characteristic that produces a transfer torque equal to that produced by the outer wheel side control coupling when the non-slip rotational speed differential is obtained. When the vehicle is running straight ahead, both control couplings are supplied with signals for selecting the transfer torque characteristics that produce maximum transfer torque for a given rotational speed differential.
摘要翻译: 扭矩分配控制装置包括两个转速差动响应型控制联接器,每个转速差动响应型控制联接器具有传递扭矩与转速差的比值不同的各种转矩转矩特性。 控制装置响应于提供给其的信号选择扭矩传递特性之一。 当转动外轮侧控制联轴器时,提供用于选择产生用于给定转速差速器的最大传递转矩的传递转矩特性的信号,并且为内轮侧控制联轴器提供用于获得防滑的信号 并且用于当获得防滑转速差时,用于选择产生与由外轮侧控制联轴器产生的传递扭矩相等的传递扭矩的传递扭矩特性。 当车辆直行前进时,两个控制联轴器都被提供有用于选择产生给定转速差速器的最大传递扭矩的传递扭矩特性的信号。
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