公开(公告)号：US6069938A

公开(公告)日：2000-05-30

申请号：US67844

申请日：1998-04-27

Applicant: Victor Ivan Chornenky ,  Dale Loren Schreiner ,  Graham Steven Kerslick ,  Michael Roy Satteson ,  Ali Jaafar

Inventor： Victor Ivan Chornenky ,  Dale Loren Schreiner ,  Graham Steven Kerslick ,  Michael Roy Satteson ,  Ali Jaafar

IPC: A61N5/10 ,  H01J35/22 ,  H05G1/20 ,  H05G1/32 ,  H05G1/34 ,  H01J35/32

CPC classification number: A61N5/1001 ,  H05G1/20 ,  H01J2201/304 ,  H01J2235/164

Abstract: An apparatus and method for exposing a treatment site in a patient to x-ray radiation is described that uses a pulse voltage source, where the x-ray emitter employs a cold cathode. The invention may further include a current sensor for measuring a current through the x-ray emitter, and, optionally, a current integrator connected to the current sensor. Each voltage pulse may be discontinued when a predetermined amount of charge has passed through the emitter. The step of moving an x-ray emitter past a treatment area at a rate determined by the amount of charge that has passed through the emitter is also described. The present invention also includes an x-ray emitter device with rectangular voltage pulses added to a base direct current voltage. Another step of the invention may be applying a voltage pulse cycle to the x-ray emitter where a duration of the pulse is 2-5 times lower than a thermal relaxation time of an emitter.

Abstract translation: 描述了一种用于将患者中的治疗部位暴露于X射线辐射的装置和方法，其使用脉冲电压源，其中x射线发射器采用冷阴极。 本发明还可以包括用于测量通过x射线发射器的电流的电流传感器，以及可选地连接到电流传感器的电流积分器。 当预定量的电荷通过发射器时，每个电压脉冲可能被中止。 还描述了以通过发射器的电荷量确定的速率将x射线发射器移动经过处理区域的步骤。 本发明还包括一个x射线发射器件，其具有添加到基极直流电压的矩形电压脉冲。 本发明的另一个步骤可以是向x射线发射器施加电压脉冲周期，其中脉冲持续时间比发射极的热松弛时间低2-5倍。

公开(公告)号：US08634929B2

公开(公告)日：2014-01-21

申请号：US12820955

申请日：2010-06-22

Applicant: Victor I. Chornenky ,  Ali Jaafar

Inventor： Victor I. Chornenky ,  Ali Jaafar

IPC: A61B18/18

CPC classification number: A61B18/1492 ,  A61B18/12 ,  A61B18/1206 ,  A61B2018/00029 ,  A61B2018/00285 ,  A61B2018/00434 ,  A61B2018/00517 ,  A61B2018/00547 ,  A61B2018/00613 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/124 ,  A61N1/325

Abstract: An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45 degrees C. to 55 degrees C., while keeping the urinary tract at a temperature 15 degrees C. to 20 degrees C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.

Abstract translation: 公开了一种用于治疗良性前列腺增生的装置和方法。 该装置包括一个施加器部件，其承载一组电极，其形状和位置以在增生体积中产生实质电场，以及脉冲发生器，适于将电脉冲传送到肿瘤细胞的上部电穿孔极限以上。 电脉冲的幅度，持续时间和数量通常被选择为引起良性前列腺增生体积的显着部分的坏死。 该装置可以包括用于加热前列腺组织的高频系统和用于冷却尿道的冷却系统。 加热和冷却的联合作用可将前列腺细胞的温度升高至45摄氏度至55摄氏度，同时将尿道保持在15摄氏度至20摄氏度的温度。该温度分布可提高选择性 通过增加肿瘤细胞对电穿孔治疗的敏感性并将其降低为正常的尿道组织来治疗。

公开(公告)号：USRE43009E1

公开(公告)日：2011-12-06

申请号：US12572005

申请日：2009-10-01

Applicant: Victor I. Chornenky ,  Ali Jaafar

Inventor： Victor I. Chornenky ,  Ali Jaafar

IPC: A61N1/18

CPC classification number: A61N1/327 ,  A61N1/0502 ,  A61N1/328

Abstract: An apparatus and method for minimally invasive treatment of deep subcutaneous fat deposits in lieu of cosmetic surgery is disclosed. The apparatus comprises a high voltage pulse generator connected to two or more needle electrodes at least one of which is configured for placement deeply under the skin in a treatment site of the patient's body. High voltage pulses, delivered to the electrodes, create an electric field that kills subcutaneous fat cells.

Abstract translation: 公开了用于代替整容手术的深层皮下脂肪沉积物的微创治疗的装置和方法。 该装置包括连接到两个或更多个针电极的高电压脉冲发生器，其中至少一个针电极被配置为深深地放置在患者身体的治疗部位的皮肤下方。 输送到电极的高电压脉冲产生杀死皮下脂肪细胞的电场。

公开(公告)号：US08005191B2

公开(公告)日：2011-08-23

申请号：US12356182

申请日：2009-01-20

Applicant: Ali Jaafar ,  Victor I. Chornenky

Inventor： Ali Jaafar ,  Victor I. Chornenky

IPC: H01J35/00

CPC classification number: H01J35/065 ,  H01J35/32

Abstract: There is disclosed herein a field emission x-ray apparatus comprising: a housing including proximal and distal housing ends; a probe including proximal and distal probe ends, wherein the proximal probe end is attach to the distal housing end and the distal probe end is sealingly closed by a cathode, and wherein the apparatus further includes an anode having proximal and distal anode ends with the distal anode end being separated from the cathode by a gap and the proximal anode end being attached to a heat sink; wherein said the further includes an outer probe surface and wherein the outer probe surface comprises a conductive probe surface coating.

Abstract translation: 这里公开了场致发射X射线设备，包括：壳体，其包括近端和远端壳体端部; 探针，其包括近端和远端探针末端，其中所述近侧探针末端附接到所述远侧壳体端部，并且所述远端探针末端由阴极密封地闭合，并且其中所述装置还包括具有近端和远端阳极端部的阳极， 阳极端通过间隙与阴极分离，并且近端阳极端附接到散热器; 其中所述另外包括外探针表面，并且其中所述外探针表面包括导电探针表面涂层。

公开(公告)号：USRE42277E1

公开(公告)日：2011-04-05

申请号：US12571927

申请日：2009-10-01

Applicant: Ali Jaafar ,  Victor I. Chornenky

Inventor： Ali Jaafar ,  Victor I. Chornenky

IPC: A61N1/18

CPC classification number: A61N1/325 ,  A61N1/0424 ,  A61N1/327 ,  A61N1/328 ,  A61N1/36014

Abstract: An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

Abstract translation: 提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。 该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。 施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。 输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。 沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。 电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

公开(公告)号：USRE42016E1

公开(公告)日：2010-12-28

申请号：US12572047

申请日：2009-10-01

Applicant: Victor I. Chornenky ,  Ali Jaafar

Inventor： Victor I. Chornenky ,  Ali Jaafar

IPC: A61F2/00 ,  A61B18/18

CPC classification number: A61N1/325 ,  A61B18/1477 ,  A61B18/1485 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61B2018/1425

Abstract: An apparatus and method for treatment of benign prostatic hyperplasia is disclosed wherein the apparatus includes an applicator having a probe having proximal and distal probe sections wherein the proximal and distal probe sections each define an axis and wherein the axes are not collinear.

Abstract translation: 公开了用于治疗良性前列腺增生的装置和方法，其中所述装置包括具有探针的施用器，所述探针具有近端和远端探针部分，其中所述近端和远端探针部分各自限定轴线，并且其中所述轴线不共线。

公开(公告)号：US20100002841A1

公开(公告)日：2010-01-07

申请号：US12356182

申请日：2009-01-20

Applicant: Ali Jaafar ,  Victor I. Chornenky

Inventor： Ali Jaafar ,  Victor I. Chornenky

IPC: H01J35/00

CPC classification number: H01J35/065 ,  H01J35/32

Abstract: There is disclosed herein a field emission x-ray apparatus comprising: a housing including proximal and distal housing ends; a probe including proximal and distal probe ends, wherein the proximal probe end is attach to the distal housing end and the distal probe end is sealingly closed by a cathode, and wherein the apparatus further includes an anode having proximal and distal anode ends with the distal anode end being separated from the cathode by a gap and the proximal anode end being attached to a heat sink; wherein said the further includes an outer probe surface and wherein the outer probe surface comprises a conductive probe surface coating.

Abstract translation: 这里公开了场致发射X射线设备，包括：壳体，其包括近端和远端壳体端部; 探针，其包括近端和远端探针末端，其中所述近侧探针末端附接到所述远侧壳体端部，并且所述远端探针末端由阴极密封地闭合，并且其中所述装置还包括具有近端和远端阳极端部的阳极， 阳极端通过间隙与阴极分离，并且近端阳极端附接到散热器; 其中所述另外包括外探针表面，并且其中所述外探针表面包括导电探针表面涂层。

公开(公告)号：US20060074303A1

公开(公告)日：2006-04-06

申请号：US11236065

申请日：2005-09-27

Applicant: Victor Chornenky ,  Ali Jaafar

Inventor： Victor Chornenky ,  Ali Jaafar

IPC: A61B5/05 ,  A61N5/00

CPC classification number: A61N5/1027 ,  A61B8/12

Abstract: A system and method providing conformal x-ray brachytherapy for treatment of tumors by irradiation of a target volume of tissue in a patient is disclosed wherein an x-ray probe including an x-ray emitter, an imaging probe configured to image the target volume, a translation stage mounting the x-ray probe for translational motion, a rotation stage mounting the x-ray probe for rotational motion, a support base mounting the x-ray and imaging probes in known relation to each other, and a computer operatively connected to the x-ray and imaging probes and the rotation and translation stages are provided to image and control the operation of the x-ray probe to irradiate the target volume according to predetermined treatment protocols.

Abstract translation: 公开了一种提供适形X射线近距离放射疗法用于通过照射患者中的组织的靶体积来治疗肿瘤的系统和方法，其中包括x射线发射器的X射线探针，被配置成对目标体积进行成像的成像探针， 安装用于平移运动的x射线探针的平移台，安装用于旋转运动的x射线探针的旋转台，将X射线和成像探针以已知关系彼此安装的支撑基座，以及可操作地连接到 提供x射线和成像探针以及旋转和平移阶段以根据预定的治疗方案对X射线探针的操作进行成像和控制以照射目标体积。

公开(公告)号：US20050182462A1

公开(公告)日：2005-08-18

申请号：US11106835

申请日：2005-04-15

Applicant: Victor Chornenky ,  Ali Jaafar

Inventor： Victor Chornenky ,  Ali Jaafar

IPC: A61N1/32 ,  A61N1/34 ,  A61F7/00 ,  A61F2/00 ,  A61F7/12

CPC classification number: A61N1/325 ,  A61N1/0424 ,  A61N1/327 ,  A61N1/328 ,  A61N1/36014

Abstract: An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

公开(公告)号：US20050038488A1

公开(公告)日：2005-02-17

申请号：US10938971

申请日：2004-09-10

Applicant: Ali Jaafar ,  Victor Chornenky

Inventor： Ali Jaafar ,  Victor Chornenky

IPC: A61N5/10 ,  H01J35/06 ,  H01J35/32 ,  A61F2/00

CPC classification number: A61N5/1001 ,  A61B1/32 ,  A61N5/1014 ,  H01J35/065 ,  H01J35/32 ,  H01J2235/064 ,  H01J2235/164

Abstract: The present invention provides apparatus and method for providing a stabilized x-ray output from a field emission x-ray apparatus by monitoring the operating current and adjusting the gap between the anode and cathode to stabilize the output.

Abstract translation: 本发明提供了一种用于通过监测工作电流并调节阳极和阴极之间的间隙来提供来自场发射x射线装置的稳定的x射线输出以稳定输出的装置和方法。