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51 条记录 (耗时 0.044 秒)

    Antisense modulation of integrin beta 4 binding protein expression
    35.
    发明申请
    Antisense modulation of integrin beta 4 binding protein expression 审中-公开
    整合素β4结合蛋白表达的反义调节

    公开(公告)号：US20060172957A1

    公开(公告)日：2006-08-03

    申请号：US10415324

    申请日：2001-11-13

    申请人： C. Bennett ,  Susan Freler

    发明人： C. Bennett ,  Susan Freler

    IPC分类号： A61K48/00 ,  C07H21/04 ,  C07F9/6512

    CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

    摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Integrin beta 4 binding protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Integrin beta 4 binding protein. Methods of using these compounds for modulation of Integrin beta 4 binding protein expression and for treatment of diseases associated with expression of Integrin beta 4 binding protein are provided.

    摘要翻译： 提供反义化合物，组合物和方法用于调节整联蛋白β4结合蛋白的表达。 组合物包含靶向编码整合素β4结合蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节整合素β4结合蛋白表达和治疗与整合素β4结合蛋白表达相关的疾病的方法。

    Microrna as ligands and target molecules
    38.
    发明申请
    Microrna as ligands and target molecules 审中-公开
    Microrna作为配体和靶分子

    公开(公告)号：US20050142581A1

    公开(公告)日：2005-06-30

    申请号：US10934798

    申请日：2004-09-03

    申请人： Richard Griffey ,  C. Bennett ,  David Ecker ,  Donna Ward ,  Susan Freier

    发明人： Richard Griffey ,  C. Bennett ,  David Ecker ,  Donna Ward ,  Susan Freier

    IPC分类号： C12N20060101 ,  C12N15/11 ,  C12N15/113 ,  C12Q1/68

    CPC分类号： C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/11 ,  C12N2330/10 ,  C12N2310/3525

    摘要： The present invention provides methods for the identification of target molecules that bind to ligands, particularly microRNA ligands and mimics thereof and/or microRNA target molecules and mimics thereof, with as little as millimolar (mM) affinity using mass spectrometry. The methods may be used to determine the mode of binding interaction between two or more of these target molecules to the ligand as well as their relative affinities. Also provided are methods for designing compounds having greater affinity to a ligand by identifying two or more target molecules using mass spectrometry methods of the invention and linking the target molecules together to form a novel compound.

    摘要翻译： 本发明提供用于使用质谱法以少至毫摩尔（mM）亲和力鉴定结合配体，特别是微小RNA配体及其模拟物和/或微小RNA靶分子及其模拟物的靶分子的方法。 该方法可用于确定这些靶分子中两个或更多个与配体之间的结合相互作用的模式以及它们的相对亲和力。 还提供了通过使用本发明的质谱方法鉴定两个或更多个靶分子并将靶分子连接在一起以形成新化合物来设计对配体具有更大亲和力的化合物的方法。