公开(公告)号：US20240337665A1

公开(公告)日：2024-10-10

申请号：US18335819

申请日：2023-06-15

Applicant: Regeneron Pharmaceuticals, Inc. ,  California Institute of Technology

Inventor： Heather Agnew ,  Bert Tsunyin Lai ,  Suresh Mark Pitram ,  Blake Farrow ,  James R. Heath ,  David Bunck ,  Jingxin Liang ,  Arundhati Nag ,  Samir Das

IPC: G01N33/68 ,  C07K7/06 ,  C07K14/54

CPC classification number: G01N33/6869 ,  C07K7/06 ,  C07K14/54

Abstract: The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.

公开(公告)号：US20240239869A1

公开(公告)日：2024-07-18

申请号：US18289674

申请日：2022-05-06

Applicant: Institute for Systems Biology ,  California Institute of Technology

Inventor： William Chour ,  James R. Heath ,  Jingyi Xie

IPC: C07K14/74 ,  A61K39/00 ,  C40B40/10

CPC classification number: C07K14/70539 ,  A61K39/4611 ,  A61K39/4632 ,  C40B40/10 ,  C07K2319/01

Abstract: Peptide-major histocompatibility (MHC) Class I nucleic acids and proteins are provided. Methods of their use, for example in methods of identifying antigen-specific T cells and adoptive cell therapy, are also provided.

公开(公告)号：US11723944B2

公开(公告)日：2023-08-15

申请号：US17322493

申请日：2021-05-17

Applicant: California Institute of Technology ,  Indi Molecular, Inc.

Inventor： Blake Farrow ,  James R. Heath ,  Heather Dawn Agnew

IPC: A61K38/00 ,  C07B59/00 ,  A61K38/12 ,  A61K38/06 ,  C07K7/52 ,  C07K5/083 ,  A61K38/08 ,  C07K7/06 ,  G01N33/531 ,  A61K47/60 ,  C07K7/08 ,  G16B5/00

CPC classification number: A61K38/005 ,  A61K38/06 ,  A61K38/08 ,  A61K38/12 ,  A61K47/60 ,  C07B59/008 ,  C07K5/0808 ,  C07K7/06 ,  C07K7/08 ,  C07K7/52 ,  G01N33/531 ,  A61K38/00 ,  C07B2200/05 ,  C07K2319/01 ,  C07K2319/70 ,  G01N2333/33 ,  G16B5/00 ,  Y02A50/30

Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US11384327B2

公开(公告)日：2022-07-12

申请号：US16347559

申请日：2017-11-01

Applicant: California Institute of Technology ,  Gwangju Institute of Science and Technology (GIST)

Inventor： Songming Peng ,  James R. Heath ,  William Chour ,  Alphonsus Hon-Chung Ng ,  Sung Yang ,  Jongchan Choi ,  Ji-Chul Hyun

IPC: C12M3/06 ,  B01L3/00 ,  G01N33/569 ,  B01F25/433 ,  B01F33/30

Abstract: Disclosed herein are methods and devices for antigen-specific T cell identification or neoantigen identification. Also disclosed herein are devices for separating and isolating antigen-specific T cells or other particles of a certain size from a population of particles of different sizes. Also describe herein are methods and devices for the separation and isolation of barcoded T cells from other nanoparticles containing barcodes for subsequent analysis and further processing of a viable T cell.

公开(公告)号：US20210369807A1

公开(公告)日：2021-12-02

申请号：US17322493

申请日：2021-05-17

Applicant: California Institute of Technology ,  Indi Molecular, Inc.

Inventor： Blake Farrow ,  James R. Heath ,  Heather Dawn Agnew

IPC: A61K38/00 ,  C07B59/00 ,  A61K38/12 ,  A61K38/06 ,  C07K7/52 ,  C07K5/083 ,  A61K38/08 ,  C07K7/06 ,  G01N33/531 ,  A61K47/60 ,  C07K7/08

Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US11007245B2

公开(公告)日：2021-05-18

申请号：US15420596

申请日：2017-01-31

Applicant: California Institute of Technology ,  Indi Molecular, Inc.

Inventor： Blake Farrow ,  James R. Heath ,  Heather Dawn Agnew

IPC: C07B59/00 ,  A61K38/00 ,  A61K38/12 ,  A61K38/06 ,  C07K7/52 ,  C07K5/083 ,  A61K38/08 ,  C07K7/06 ,  G01N33/531 ,  A61K47/60 ,  C07K7/08 ,  G16B5/00

Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US10975123B2

公开(公告)日：2021-04-13

申请号：US15680171

申请日：2017-08-17

Applicant: California Institute of Technology

Inventor： Kaycie Deyle ,  Blake Farrow ,  James R. Heath

IPC: A61K38/00 ,  C07K7/06 ,  G01N33/573 ,  C07K7/00 ,  C12N9/12 ,  G01N33/574 ,  C07K14/00

Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US20200040293A1

公开(公告)日：2020-02-06

申请号：US16347559

申请日：2017-11-01

Applicant: California Institute of Technology ,  Gwangju Institute of Science and Technology (GIST)

Inventor： Songming Peng ,  James R. Heath ,  William Chour ,  Alphonsus H.c. Ng ,  Sung Yang ,  Jongchan Choi ,  Ji-Chul Hyun

IPC: C12M3/06 ,  B01F13/00 ,  B01F5/06 ,  B01L3/00 ,  G01N33/569

Abstract: Disclosed herein are methods and devices for antigen-specific T cell identification or neoantigen identification. Also disclosed herein are devices for separating and isolating antigen- specific T cells or other particles of a certain size from a population of particles of different sizes. Also describe herein are methods and devices for the separation and isolation of barcoded T cells from other nanoparticles containing barcodes for subsequent analysis and further processing of a viable T cell.

公开(公告)号：US20150219657A1

公开(公告)日：2015-08-06

申请号：US14485243

申请日：2014-09-12

Applicant: California Institute of Technology

Inventor： James R. Heath ,  Arundhati Nag ,  Samir Das ,  Joseph O. Varghese ,  Ryan K. Henning

IPC: G01N33/574 ,  G01N33/58 ,  C07K7/06

Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.

Abstract translation: 本申请提供了稳定的基于肽的Akt捕获剂以及用作检测和诊断试剂以及用于治疗疾病和病症的方法。 该应用进一步提供了使用迭代的珠粒原位点击化学制造Akt捕获剂的方法。

公开(公告)号：US20230076204A1

公开(公告)日：2023-03-09

申请号：US17800311

申请日：2021-02-18

Applicant: Institute for Systems Biology ,  California Institute of Technology

Inventor： James R. Heath ,  William Chour ,  Rongyu Zhang

IPC: C07K14/74 ,  C12N15/79 ,  C40B40/08 ,  C40B40/10 ,  G01N33/569

Abstract: Peptide-major histocompatibility (MHC) Class II nucleic acids and proteins are provided. Methods of their use, for example in methods of identifying antigen-specific T cells and adoptive cell therapy, are also provided.