公开(公告)号：US07111104B2

公开(公告)日：2006-09-19

申请号：US11110906

申请日：2005-04-21

申请人： Xi Chen ,  Brian Chang

发明人： Xi Chen ,  Brian Chang

IPC分类号： H04J1/10

CPC分类号： H04L49/351 ,  G06F13/4095 ,  H04L12/46 ,  H04L49/3027

摘要： A system for connecting multiple repeaters into a single collision domain comprising a first repeater, a second repeater and a stacking bus. The first repeater has a plurality of network ports. The second repeater also has a plurality of network ports. The stacking bus connects the first repeater and the second repeater and is configured to relay status signals between the first and said second repeaters.

摘要翻译： 一种用于将多个中继器连接成单个冲突域的系统，包括第一中继器，第二中继器和堆叠总线。 第一中继器具有多个网络端口。 第二中继器还具有多个网络端口。 堆叠总线连接第一中继器和第二中继器，并且被配置为中继第一和第二中继器之间的状态信号。

公开(公告)号：US20060100225A1

公开(公告)日：2006-05-11

申请号：US11088276

申请日：2005-03-23

申请人： Xi Chen ,  Ciuxan Liu ,  Andrew Thurkauf ,  Shirley Louise-May

发明人： Xi Chen ,  Ciuxan Liu ,  Andrew Thurkauf ,  Shirley Louise-May

IPC分类号： A61K31/513 ,  A61K31/505 ,  C07D239/32

CPC分类号： C07C279/18 ,  C07D213/75 ,  C07D213/82 ,  C07D239/42 ,  C07D239/47 ,  C07D239/545 ,  C07D239/84 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

摘要： Compounds of Formula 1, and pharmaceutically acceptable forms thereof, are provided: wherein the variables X, Y, Z, A1, R2, R3, R4, R5 and R6 are defined herein. Certain compounds of Formula 1 described herein which possess potent antiviral activity. Certain compounds of Formula 1 that are potent and/or selective inhibitors of Hepatitis C virus replication. Pharmaceutical compositions containing one or more compounds of Formula 1, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents are also provided. Methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula 1 effective to reduce signs or symptoms of the disease or disorder are disclosed. These infectious diseases include viral infections, particularly HCV infections. Methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula 1 as a single active agent or administering a compound of Formula 1 in combination with on or more other therapeutic agent.

摘要翻译： 提供式1化合物及其药学上可接受的形式：其中变量X，Y，Z，A 1，R 2，R 3， R 4，R 5，R 5和R 6在本文中定义。 某些本文所述的具有强抗病毒活性的式1的化合物。 某些化合物1是丙型肝炎病毒复制的有效和/或选择性抑制剂。 还提供了含有一种或多种式1化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。 公开了通过向这些患者施用一定量的有效减少疾病或病症的体征或症状的式1化合物来治疗患有某些感染性疾病的患者的方法。 这些传染病包括病毒感染，特别是HCV感染。 治疗患有感染性疾病的人类患者的方法，还包括治疗其他动物，包括患有传染病的家畜和驯养的伴侣动物的方法。 治疗方法包括施用作为单一活性剂的式1化合物或与一种或多种其它治疗剂组合施用式1的化合物。

公开(公告)号：US06963288B1

公开(公告)日：2005-11-08

申请号：US09652477

申请日：2000-08-31

申请人： Michael Sokol ,  Xi Chen

发明人： Michael Sokol ,  Xi Chen

IPC分类号： G05B23/02 ,  G08B5/22

CPC分类号： G05B19/042 ,  G05B2219/23154

摘要： A programmable LED display system is disclosed. The system includes a programmable controller, a driver operative to generate a control signal in response to a signal provided by the programmable controller, and a display device operative to provide a visual representation of the state of the system in response to the control signal. The system also includes means for determining which state condition is displayed when more than one state condition exists.

摘要翻译： 公开了一种可编程LED显示系统。 该系统包括可编程控制器，用于响应于由可编程控制器提供的信号而产生控制信号的驱动器，以及可响应于控制信号提供系统状态的视觉表示的显示装置。 该系统还包括用于当存在多于一个状态条件时确定显示状态的装置。

公开(公告)号：US20050120410A1

公开(公告)日：2005-06-02

申请号：US10505744

申请日：2003-03-05

申请人： Tesfaye Mengiste ,  Xi Chen ,  John Salmeron ,  Robert Dietrich

发明人： Tesfaye Mengiste ,  Xi Chen ,  John Salmeron ,  Robert Dietrich

IPC分类号： C07K14/415 ,  C12N15/29 ,  C12N15/82 ,  A01H1/00 ,  C07H21/04 ,  C12N9/24

CPC分类号： C12N15/8271 ,  C07K14/415 ,  C12N15/8216 ,  C12N15/8279 ,  C12N15/8282

摘要： The present invention pertains to nucleic acid molecules isolated from Arabidopisis thaliana comprising nucleotide sequences that encode proteins for biotic and abiotic stress tolerance. The invention particularly relates to methods of using nucleic acid molecules and/or proteins from Arabidopisis in transgenic plants to confer enhanced biotic and/or abiotic stress tolerance, and to use such nucleic acids to assist germplasm enhancement by breeding. In particular, the invention pertains to nucleic acid molecules isolated from Arabidopisis thaliana of the BOS1 cDNA and genomic gene and encoding the BOS1 polypeptide. The present invention also pertains to nucleic acid molecules isolated from Arabidopisis thaliana that encode a promoter from the BOS1 gene, and methods of using the promoter. Also, the invention relates to host cells, plants or progeny thereof comprising the nucleic acid molecules or recombinant molecules described herein.

摘要翻译： 本发明涉及从拟南芥中分离的核酸分子，其包含编码用于生物和非生物胁迫耐受性的蛋白质的核苷酸序列。 本发明特别涉及在转基因植物中使用来自Arabidopisis的核酸分子和/或蛋白质赋予增强的生物和/或非生物胁迫耐受性的方法，并且使用这样的核酸通过育种来辅助种质增殖。 特别地，本发明涉及从BOS1 cDNA和基因组基因的拟南芥中分离的编码BOS1多肽的核酸分子。 本发明还涉及从编码来自BOS1基因的启动子的拟南芥中分离的核酸分子以及使用该启动子的方法。 此外，本发明涉及包含本文所述的核酸分子或重组分子的宿主细胞，植物或其后代。

公开(公告)号：US20050031584A1

公开(公告)日：2005-02-10

申请号：US10410980

申请日：2003-04-09

申请人： Shawn DeFrees ,  David Zopf ,  Robert Bayer ,  Caryn Bowe ,  David Hakes ,  Xi Chen

发明人： Shawn DeFrees ,  David Zopf ,  Robert Bayer ,  Caryn Bowe ,  David Hakes ,  Xi Chen

IPC分类号： A61K38/00 ,  C07K1/00 ,  C07K1/107 ,  C07K1/13 ,  C07K9/00 ,  C07K14/505 ,  A61K38/20 ,  C07K14/54

CPC分类号： C07K1/006 ,  A61K38/00 ,  C07K1/1077 ,  C07K1/13 ,  C07K9/00 ,  C07K14/505

摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.

摘要翻译： 本发明包括用于重组肽分子的方法和组合物，包括向肽添加或缺失一个或多个糖基，和/或向肽中加入修饰基团。

公开(公告)号：US20050024225A1

公开(公告)日：2005-02-03

申请号：US10929784

申请日：2004-08-31

申请人： Michael Sokol ,  Xi Chen

发明人： Michael Sokol ,  Xi Chen

IPC分类号： G05B23/02 ,  G06F15/173

CPC分类号： G05B19/042 ,  G05B2219/23154

摘要： A programmable LED display system is disclosed. The system includes a programmable controller; a driver operative to generate a control signal in response to a signal provided by the programmable controller; and a display device operative to provide a visual representation of the state of the system in response to the control signal. The system also includes means for determining which state condition is displayed when more than one state condition exists.

摘要翻译： 公开了一种可编程LED显示系统。 该系统包括一个可编程控制器; 驱动器，用于响应于由可编程控制器提供的信号而产生控制信号; 以及显示装置，其可操作以响应于所述控制信号提供所述系统的状态的视觉表示。 该系统还包括用于当存在多于一个状态条件时确定显示状态的装置。

公开(公告)号：US6008352A

公开(公告)日：1999-12-28

申请号：US34189

申请日：1998-03-03

申请人： Xi Chen

发明人： Xi Chen

IPC分类号： C07D217/22 ,  C07D405/12 ,  C07D401/04 ,  C07D405/14

CPC分类号： C07D405/12 ,  C07D217/22

摘要： Disclosed are compounds useful in treating psychotic disorders such as schizophrenia and other central nervous system diseases, where the compounds have general Formula I: ##STR1## wherein: Ar represents an aryl or heteroaryl group;R.sub.1 and R.sub.2 independently represent hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, hydroxy, amino, mono- or di(C.sub.1 -C.sub.6)alkyl amino, cyano or trifluoromethyl; andR.sub.5 represents hydrogen or C.sub.1 -C.sub.6 alkyl.

摘要翻译： 公开了可用于治疗精神病如精神分裂症和其他中枢神经系统疾病的化合物，其中化合物具有通式I：其中：Ar表示芳基或杂芳基; R 1和R 2独立地表示氢，卤素，C 1 -C 6烷基，C 1 -C 4烷氧基，C 1 -C 4烷硫基，羟基，氨基，单或二（C 1 -C 6）烷基氨基，氰基或三氟甲基; 并且R 5表示氢或C 1 -C 6烷基。

公开(公告)号：US5883257A

公开(公告)日：1999-03-16

申请号：US994588

申请日：1997-12-19

申请人： Jun Yuan ,  Xi Chen

发明人： Jun Yuan ,  Xi Chen

IPC分类号： C07D295/12 ,  A61K31/44 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P25/00 ,  A61P25/18 ,  A61P25/20 ,  A61P25/28 ,  A61P25/30 ,  C07D211/14 ,  C07D211/28 ,  C07D211/70 ,  C07D217/02 ,  C07D295/13 ,  C07D401/12

CPC分类号： C07D295/13 ,  C07D211/14 ,  C07D211/70 ,  C07C2103/24

摘要： Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C.sub.1 -C.sub.6 alkoxy, --O.sub.2 CR', --NHCOR', --COR', --SO.sub.m R', where R' is C.sub.1 -C.sub.6 alkyl and wherein m is 0, 1 or 2; orR.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.10 is hydrogen or C.sub.1 -C.sub.6 alkyl; andR represents an aminoalkyl group;which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.

摘要翻译： 公开了下式的化合物或其药学上可接受的酸加成盐，其中：R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9相同或不同，表示氢，C 1 -C 6 烷基，卤素，羟基，氨基，氰基，硝基，三氟甲基，三氟甲氧基，C 1 -C 6烷氧基，-O 2 CR'，-NHCOR'，-COR'，-SO m R'，其中R'是C 1 -C 6烷基， ，1或2; 或R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9独立地表示-CONR'R“或-NR'R”，其中R'和R“独立地表示氢或C1-C6烷基; R 10是氢或C 1 -C 6烷基; R表示氨基烷基; 哪些化合物可用于治疗情感障碍如精神分裂症，抑郁症，阿尔茨海默氏病，运动障碍如帕金森综合征和肌张力障碍，以及其他对多巴胺能阻滞作用的药物滥用和强迫症。 此外，本发明的化合物可用于治疗与使用常规精神抑制剂相关的锥体束外副作用。

公开(公告)号：US5703235A

公开(公告)日：1997-12-30

申请号：US619351

申请日：1996-03-21

申请人： Jun Yuan ,  Xi Chen

发明人： Jun Yuan ,  Xi Chen

IPC分类号： C07D295/12 ,  A61K31/44 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P25/00 ,  A61P25/18 ,  A61P25/20 ,  A61P25/28 ,  A61P25/30 ,  C07D211/14 ,  C07D211/28 ,  C07D211/70 ,  C07D217/02 ,  C07D295/13 ,  C07D401/10 ,  C07D295/15

CPC分类号： C07D295/13 ,  C07D211/14 ,  C07D211/70 ,  C07C2103/24

摘要： Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C.sub.1 -C.sub.6 alkoxy, --O.sub.2 CR', --NHCOR', --COR', --SO.sub.m R', where R' is C.sub.1 -C.sub.6 alkyl and wherein m is 0, 1 or 2; or R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.10 is hydrogen or C.sub.1 -C.sub.6 alkyl; and R represents an aminoalkyl group; which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.

摘要翻译： 公开了下式的化合物或其药学上可接受的酸加成盐，其中：R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9相同或不同，表示氢，C 1 -C 6 烷基，卤素，羟基，氨基，氰基，硝基，三氟甲基，三氟甲氧基，C 1 -C 6烷氧基，-O 2 CR'，-NHCOR'，-COR'，-SO m R'，其中R'是C 1 -C 6烷基， ，1或2; 或R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9独立地表示-CONR'R“或-NR'R”，其中R'和R“独立地表示氢或C1-C6烷基; R 10是氢或C 1 -C 6烷基; R表示氨基烷基; 哪些化合物可用于治疗情感障碍如精神分裂症，抑郁症，阿尔茨海默氏病，运动障碍如帕金森综合征和肌张力障碍，以及其他对多巴胺能阻滞作用的药物滥用和强迫症。 此外，本发明的化合物可用于治疗与使用常规精神抑制剂相关的锥体束外副作用。

公开(公告)号：US09980569B1

公开(公告)日：2018-05-29

申请号：US15406447

申请日：2017-01-13

申请人： Xi Chen

发明人： Xi Chen

IPC分类号： A47C1/12 ,  A47C7/00 ,  A47C5/00

CPC分类号： A47C7/002 ,  A47C3/12

摘要： An axial and compressive load support assembly for supporting an axial load and longitudinal compression provides axial load and compressive support for a seat and a load. The assembly provides support through a vertical polyhedron member with radially extending L-shaped legs that from an obtuse angle. The polyhedron member bears an axial load, such as the seat and a load. A plurality of struts extend between the legs and the polyhedron member at an angle. The struts resist longitudinal compression by providing outwards-facing support in a lengthwise direction. A crossbar extends between the strut and the legs. The crossbar is defined by apertures configured to align with the fastening holes in the polyhedron member and enable passage of at least one fastener for detachably fastening the connected legs, struts, and crossbars to the polyhedron member. A wooden extension can be integrated into the second rod of the legs.