公开(公告)号：US07405229B2

公开(公告)日：2008-07-29

申请号：US10560672

申请日：2004-06-28

申请人： Christopher Bayly ,  Cameron Black ,  Sheldon Crane ,  Daniel J. McKay ,  Renata Oballa ,  Joel Robichaud

发明人： Christopher Bayly ,  Cameron Black ,  Sheldon Crane ,  Daniel J. McKay ,  Renata Oballa ,  Joel Robichaud

IPC分类号： A61K31/44 ,  A61K31/445 ,  A61K31/417 ,  A61K31/4184 ,  C07D211/80 ,  C07D233/54 ,  C07D235/04

CPC分类号： C07D213/83 ,  C07C255/29 ,  C07C311/06 ,  C07C323/25 ,  C07C323/49 ,  C07C323/60 ,  C07C323/61 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/14 ,  C07D211/20 ,  C07D213/32 ,  C07D231/12 ,  C07D233/64 ,  C07D235/06 ,  C07D257/04

摘要： This invention relates to a class of compounds having the general formula (I) which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

摘要翻译： 本发明涉及一类具有通式（I）的化合物，它是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中抑制骨的疾病 表示吸收，如骨质疏松症。

公开(公告)号：US07371747B2

公开(公告)日：2008-05-13

申请号：US10495387

申请日：2002-11-13

申请人： Cameron Black ,  Sheldon N. Crane ,  Dana Davis ,  Eduardo L. Setti

发明人： Cameron Black ,  Sheldon N. Crane ,  Dana Davis ,  Eduardo L. Setti

IPC分类号： A61K31/535

CPC分类号： C07D213/40 ,  C07C317/44 ,  C07C323/60 ,  C07C323/65 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/02 ,  C07C2602/16 ,  C07C2602/20 ,  C07C2602/42 ,  C07C2602/50 ,  C07D211/58 ,  C07D213/32 ,  C07D213/70 ,  C07D213/74 ,  C07D213/81 ,  C07D213/82 ,  C07D233/84 ,  C07D239/38 ,  C07D263/58 ,  C07D277/16 ,  C07D277/42 ,  C07D277/74 ,  C07D307/38 ,  C07D333/20

摘要： The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by unregulated cysteine protease activity, in particular cathepsin K utilizing these compounds and methods of preparing these compounds are also disclosed.

摘要翻译： 本发明涉及新的氰基烷基氨基衍生物，其是半胱氨酸蛋白酶如组织蛋白酶K，S，B和L的抑制剂，特别是组织蛋白酶K包含这些化合物的药物组合物，治疗由不受调节的半胱氨酸蛋白酶活性介导的疾病的方法，特别是组织蛋白酶 还公开了利用这些化合物的K和制备这些化合物的方法。

公开(公告)号：US20060287402A1

公开(公告)日：2006-12-21

申请号：US10569351

申请日：2004-08-23

申请人： Christopher Bayly ,  Cameron Black ,  Daniel McKay

发明人： Christopher Bayly ,  Cameron Black ,  Daniel McKay

IPC分类号： A61K31/13 ,  C07C211/01

CPC分类号： C07D295/108 ,  C07C255/24 ,  C07C255/29 ,  C07C255/46 ,  C07C323/41 ,  C07C2601/02 ,  C07D223/08 ,  C07D295/135 ,  C07D307/33 ,  C07D333/20 ,  C07D333/24 ,  C07D401/12 ,  C07K5/06191

摘要： This invention relates to a novel class of compounds, represented by the formula (I) below, wherein the meanings of R1, R2, R3 and R4 are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, osteoarthritis and rheumatoid arthritis.

摘要翻译： 本发明涉及由下式（I）表示的新一类化合物，其中R 1，R 2，R 3，R 3， SUB>和R 4，其中是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中抑制 骨吸收表现为骨质疏松症，骨关节炎和类风湿性关节炎。

公开(公告)号：US20050203864A1

公开(公告)日：2005-09-15

申请号：US10941065

申请日：2004-09-13

申请人： Ross Schmidt ,  Robert Craig ,  Cameron Black ,  Sean Brockway ,  Todd Partington

发明人： Ross Schmidt ,  Robert Craig ,  Cameron Black ,  Sean Brockway ,  Todd Partington

IPC分类号： G06F17/30

CPC分类号： G06F16/116

摘要： An automated data management system and method for logging, processing, and reporting a large volume of data having different file types, using different versions, stored on different media, and/or run by different operating systems, includes a first processor for restoring a plurality of received data files, the data files being capable of being different file types; a file organizing/categorizing processor for organizing the received data files into data slices, each data slice including an identification number and a descriptor that describes characteristics of the received data file; a file logging processor for logging the received data files into a first database based on the data slices; a data uploading processor for uploading the first database to a second database; a de-duplicate processor for calculating a SHA value of the received data files to determine whether the received data files have duplicates and flagging duplicated data files in the second database; an image conversion processor for converting at least a portion of the received data files into image files; and a second processor for exporting the image files.

摘要翻译： 一种自动数据管理系统和方法，用于记录，处理和报告具有不同文件类型的大量数据，使用不同版本，存储在不同介质上和/或由不同操作系统运行，包括用于恢复多个 的数据文件，数据文件能够是不同的文件类型; 文件组织/分类处理器，用于将接收到的数据文件组织成数据片，每个数据片包括标识号和描述符，描述接收的数据文件的特征; 文件记录处理器，用于基于所述数据切片将所接收的数据文件记录到第一数据库中; 用于将第一数据库上载到第二数据库的数据上传处理器; 用于计算接收的数据文件的SHA值以确定所接收的数据文件是否具有在第二数据库中的重复和标记复制的数据文件的去重复处理器; 图像转换处理器，用于将所接收的数据文件的至少一部分转换为图像文件; 以及用于导出图像文件的第二处理器。

公开(公告)号：US5922742A

公开(公告)日：1999-07-13

申请号：US832407

申请日：1997-04-02

申请人： Cameron Black ,  Zhaoyin Wang ,  Greg Hughes

发明人： Cameron Black ,  Zhaoyin Wang ,  Greg Hughes

IPC分类号： C07D213/50 ,  C07D213/61 ,  C07D213/64 ,  A61K31/44 ,  C07D211/72

CPC分类号： C07D213/64 ,  C07D213/50 ,  C07D213/61

摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.

摘要翻译： 本发明包括式I的新化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用本发明还包括 用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。

公开(公告)号：US5733909A

公开(公告)日：1998-03-31

申请号：US784663

申请日：1997-01-21

申请人： Cameron Black ,  Mario Girard ,  Daniel Guay ,  Zhaoyin Wang

发明人： Cameron Black ,  Mario Girard ,  Daniel Guay ,  Zhaoyin Wang

IPC分类号： C07C317/44 ,  A01N41/10 ,  A61K31/535 ,  C07C311/29

CPC分类号： C07C317/44

摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。 本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。

公开(公告)号：US07928091B2

公开(公告)日：2011-04-19

申请号：US11988346

申请日：2006-07-05

申请人： Cameron Black ,  Sheldon Crane ,  Renata Oballa ,  Joel Robichaud

发明人： Cameron Black ,  Sheldon Crane ,  Renata Oballa ,  Joel Robichaud

IPC分类号： A61K31/663 ,  C07D231/12

CPC分类号： C07D231/12

摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

公开(公告)号：US20080255072A1

公开(公告)日：2008-10-16

申请号：US11885421

申请日：2006-02-24

申请人： Anastasia Daifotis ,  Selwyn Aubrey Stoch ,  Basil Avery Ince ,  Cameron Black

发明人： Anastasia Daifotis ,  Selwyn Aubrey Stoch ,  Basil Avery Ince ,  Cameron Black

IPC分类号： A61K31/59 ,  A61K31/165 ,  A61P1/00 ,  A61K31/44

CPC分类号： A61K31/277 ,  A61K9/20 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/275 ,  A61K31/415 ,  A61K31/427 ,  A61K31/44 ,  A61K31/59 ,  A61K31/592 ,  A61K45/06 ,  C07C317/32 ,  A61K2300/00

摘要： The present invention relates to the a method of inhibiting bone resorption in a mammal in need thereof with an oral pharmaceutical composition comprising a cathepsin K inhibitor, or a pharmaceutically acceptable salt thereof, or a mixture thereof, according to a continuous schedule having a dosage interval of once weekly, biweekly, twice monthly or once monthly.

摘要翻译： 本发明涉及根据具有剂量间隔的连续方案，通过含有组织蛋白酶K抑制剂或其药学上可接受的盐或其混合物的口服药物组合物来抑制有需要的哺乳动物的骨吸收的方法 每周一次，每两周一次，每月两次或每月一次。

公开(公告)号：US20070167635A1

公开(公告)日：2007-07-19

申请号：US10560672

申请日：2004-06-28

申请人： Christopher Bayly ,  Cameron Black ,  Sheldon Crane ,  Daniel McKay ,  Renata Oballa ,  Joel Robichaud

发明人： Christopher Bayly ,  Cameron Black ,  Sheldon Crane ,  Daniel McKay ,  Renata Oballa ,  Joel Robichaud

IPC分类号： G01N33/48 ,  C07D233/14 ,  C07D233/22

CPC分类号： C07D213/83 ,  C07C255/29 ,  C07C311/06 ,  C07C323/25 ,  C07C323/49 ,  C07C323/60 ,  C07C323/61 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/14 ,  C07D211/20 ,  C07D213/32 ,  C07D231/12 ,  C07D233/64 ,  C07D235/06 ,  C07D257/04

摘要： This invention relates to a class of compounds having the general formula (I) which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

摘要翻译： 本发明涉及一类具有通式（I）的化合物，它是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中抑制骨的疾病 表示吸收，如骨质疏松症。

公开(公告)号：US07103602B2

公开(公告)日：2006-09-05

申请号：US09944712

申请日：2001-08-31

申请人： Cameron Black ,  Ross A. Schmidt ,  Sean M. Brockway ,  Robert M. Craig ,  Todd Partington

发明人： Cameron Black ,  Ross A. Schmidt ,  Sean M. Brockway ,  Robert M. Craig ,  Todd Partington

IPC分类号： G06F17/00

CPC分类号： G06F17/30067 ,  Y10S707/915 ,  Y10S707/922 ,  Y10S707/99942

摘要： An automated data management system and method for logging, processing, and reporting a large volume of data having different file types, stored on different media, and/or run by different operating systems, includes a first server processor for restoring a plurality of received data files, the data files being capable of being different file types; a file organizing/categorizing processor for organizing the received data files, based on a predetermined user list, into a source directory structure and a destination directory structure; a file logging processor for logging the received data files into a database formed by the source and destination directory structures and identifying a file type of the received data files; a de-duplicate processor for calculating a SHA value of the received data files to determine whether the received data files have duplicates and flagging duplicated data files in the database; an image conversion processor for converting the remaining data files into image files, respectively; and a second server processor for exporting the image files.