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公开(公告)号：US07405229B2
公开(公告)日：2008-07-29
申请号：US10560672
申请日：2004-06-28
申请人： Christopher Bayly , Cameron Black , Sheldon Crane , Daniel J. McKay , Renata Oballa , Joel Robichaud
发明人： Christopher Bayly , Cameron Black , Sheldon Crane , Daniel J. McKay , Renata Oballa , Joel Robichaud
IPC分类号： A61K31/44 , A61K31/445 , A61K31/417 , A61K31/4184 , C07D211/80 , C07D233/54 , C07D235/04
CPC分类号： C07D213/83 , C07C255/29 , C07C311/06 , C07C323/25 , C07C323/49 , C07C323/60 , C07C323/61 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07D211/20 , C07D213/32 , C07D231/12 , C07D233/64 , C07D235/06 , C07D257/04
摘要： This invention relates to a class of compounds having the general formula (I) which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类具有通式（I）的化合物，它是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中抑制骨的疾病 表示吸收，如骨质疏松症。
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公开(公告)号：US20070167635A1
公开(公告)日：2007-07-19
申请号：US10560672
申请日：2004-06-28
申请人： Christopher Bayly , Cameron Black , Sheldon Crane , Daniel McKay , Renata Oballa , Joel Robichaud
发明人： Christopher Bayly , Cameron Black , Sheldon Crane , Daniel McKay , Renata Oballa , Joel Robichaud
IPC分类号： G01N33/48 , C07D233/14 , C07D233/22
CPC分类号： C07D213/83 , C07C255/29 , C07C311/06 , C07C323/25 , C07C323/49 , C07C323/60 , C07C323/61 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07D211/20 , C07D213/32 , C07D231/12 , C07D233/64 , C07D235/06 , C07D257/04
摘要： This invention relates to a class of compounds having the general formula (I) which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类具有通式（I）的化合物，它是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中抑制骨的疾病 表示吸收，如骨质疏松症。
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公开(公告)号：US20090093444A1
公开(公告)日：2009-04-09
申请号：US11988346
申请日：2006-07-05
申请人： Cameron Black , Sheldon Crane , Renata Oballa , Joel Robichaud
发明人： Cameron Black , Sheldon Crane , Renata Oballa , Joel Robichaud
IPC分类号： A61K31/663 , C07D231/12 , A61K31/59 , A61P19/00 , A61P35/00 , A61P11/00 , A61P3/00 , A61P19/10 , A61K31/415
CPC分类号： C07D231/12
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如 骨质疏松症
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公开(公告)号：US07928091B2
公开(公告)日：2011-04-19
申请号：US11988346
申请日：2006-07-05
申请人： Cameron Black , Sheldon Crane , Renata Oballa , Joel Robichaud
发明人： Cameron Black , Sheldon Crane , Renata Oballa , Joel Robichaud
IPC分类号： A61K31/663 , C07D231/12
CPC分类号： C07D231/12
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
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公开(公告)号：US20100063013A1
公开(公告)日：2010-03-11
申请号：US12532652
申请日：2008-03-25
IPC分类号： A61K31/395 , C07D285/00 , A61K31/496 , A61P3/00 , A61P29/00 , A61K31/59 , A61K31/663
CPC分类号： C07D273/02 , C07D245/02 , C07D285/00
摘要： The present invention relates to novel compounds of the formula (I), wherein R′-R7, X, Y, D and n are as defined in the specification. These compounds are cysteine protease inhibitors which include but are not limited to inhibitors of cathepsms K, L, S and B and are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及式（I）的新化合物，其中R'-R7，X，Y，D和n如说明书中所定义。 这些化合物是半胱氨酸蛋白酶抑制剂，其包括但不限于组织蛋白酶K，L，S和B的抑制剂，并且可用于治疗其中指示骨吸收抑制的疾病，例如骨质疏松症。
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6.发明申请Azetidine Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase 审中-公开氮杂环丁烷衍生物作为硬脂酰辅酶Delta-9去饱和酶的抑制剂公开(公告)号：US20090170828A1
公开(公告)日：2009-07-02
申请号：US12227544
申请日：2007-06-08
申请人： Elise Isabel , Renata Oballa , David Powell , Joel Robichaud
发明人： Elise Isabel , Renata Oballa , David Powell , Joel Robichaud
IPC分类号： A61K31/397 , C07D277/20 , C07D403/02 , C07D401/02 , A61P3/04 , A61P3/10 , A61P9/10
CPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D413/14 , C07D417/04
摘要： Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis. (I)
摘要翻译： 结构式I的氮杂环丁烷衍生物是相对于其它已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶A delta-9去饱和酶（SCD1）的选择性抑制剂。 本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病; 动脉粥样硬化 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 肝脂肪变性 和非酒精性脂肪性肝炎。 （一世）
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7.发明申请Papain Family Cysteine Protease Inhibitors for the Treatment of Parasitic Diseases 审中-公开木瓜蛋白酶家族半胱氨酸蛋白酶抑制剂治疗寄生虫病公开(公告)号：US20090264479A1
公开(公告)日：2009-10-22
申请号：US11989437
申请日：2006-07-24
IPC分类号： A61K31/4402 , A61K31/165 , A61P33/00
CPC分类号： A61K31/275 , A61K45/06 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , A61K2300/00
摘要： Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition of these proteases can be useful in the treatment of these parasitic diseases, including toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis or schistosomiasis.
摘要翻译： 负责哺乳动物疾病的几种寄生虫依赖于各种生命周期功能的半胱氨酸蛋白酶。 抑制这些蛋白酶可用于治疗这些寄生虫病，包括弓形体病，疟疾，非洲锥虫病，恰加斯病，利什曼病或血吸虫病。
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公开(公告)号：US20090291988A1
公开(公告)日：2009-11-26
申请号：US11922120
申请日：2006-06-14
申请人： Renata Oballa
发明人： Renata Oballa
IPC分类号： A61K31/165 , C07C255/46 , C07C235/34 , C07C237/24 , C07D213/56 , C07C211/27 , A61K31/275 , A61K31/4418 , A61K31/137 , A61P25/00
CPC分类号： C07C255/46 , C07C235/34 , C07C235/40 , C07C237/24 , C07C2601/02 , C07D213/56
摘要： The instant invention relates to compounds of formula I, diagrammed below, wherein R3, E, D and Y are defined in the application, which are useful as reversible inhibitors of monoamine oxidase-B and/or monoamine oxidase-A, and therefore useful to treat or prevent neurological diseases or conditions in mammals, preferably humans.
摘要翻译： 本发明涉及下文所示的式I化合物，其中R3，E，D和Y在本申请中有定义，其可用作单胺氧化酶-B和/或单胺氧化酶-A的可逆抑制剂，因此可用于 治疗或预防哺乳动物，优选人类的神经疾病或病症。
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