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公开(公告)号：US20070027113A1
公开(公告)日：2007-02-01
申请号：US10832816
申请日：2004-04-26
申请人： James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Thorsten Kirschberg , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins
发明人： James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Thorsten Kirschberg , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins
IPC分类号： A61K31/675 , A61K31/519
CPC分类号： A61K31/519 , A61K31/662 , A61K31/675 , A61K47/54 , A61K47/548
摘要： The invention is related to phosphorus substituted purine nucleoside phosphorylase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的嘌呤核苷磷酸化酶抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20050261237A1
公开(公告)日：2005-11-24
申请号：US10832810
申请日：2004-04-26
申请人： Constantine Boojamra , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Alan Huang , Choung Kim , Thorsten Kirschberg , Christopher Lee , David Oare , Vidya Prasad , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins
发明人： Constantine Boojamra , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Alan Huang , Choung Kim , Thorsten Kirschberg , Christopher Lee , David Oare , Vidya Prasad , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins
IPC分类号： A61K31/675 , A61K31/7072 , A61K31/7076
CPC分类号： C07F9/65616 , C07F9/65586 , C07F9/6561 , C07H7/04 , C07H19/056 , C07H19/06 , C07H19/14 , C07H19/173
摘要： The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的核苷化合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US07253180B2
公开(公告)日：2007-08-07
申请号：US10687373
申请日：2003-10-16
申请人： James M. Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung U. Kim , Laura N. Schacherer
发明人： James M. Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung U. Kim , Laura N. Schacherer
IPC分类号： A01N43/42 , A61K31/44 , C07D471/00 , C07D491/00 , C07D498/00
CPC分类号： C07D207/404 , C07D471/04 , C07D487/04
摘要： Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
摘要翻译： 公开了根据以下结构的三环化合物，其受保护的中间体和用于抑制HIV整合酶的方法。 A 1和A 2是形成五，六或七元环的部分。 L是连接Ar与N的环原子的键或连接体.X是O，S或取代的氮。 Ar是芳基或杂芳基。 Q是N， + NR，或CR 4。 芳基碳可以独立地被除氢以外的取代基取代。 化合物可以包括共价连接在任何位点的前药部分。
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公开(公告)号：US20090029939A1
公开(公告)日：2009-01-29
申请号：US11807303
申请日：2007-05-25
申请人： James M. Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung U. Kim , Laura N. Schacherer
发明人： James M. Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung U. Kim , Laura N. Schacherer
IPC分类号： A61K31/7072 , C07D471/04 , A61K31/437 , A61K31/5377 , A61K31/496 , A61P31/18 , A61K31/675 , C07F9/58 , C12N5/06 , C07D487/04
CPC分类号： C07D207/404 , C07D471/04 , C07D487/04
摘要： Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl, Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
摘要翻译： 公开了根据以下结构的三环化合物，其受保护的中间体和用于抑制HIV整合酶的方法。 A1和A2是形成五，六或七元环的部分。 L是连接Ar与N的环原子的键或连接体.X是O，S或取代的氮。 Ar是芳基或杂芳基，Q是N，+ NR或CR 4。 芳基碳可以独立地被除氢以外的取代基取代。 化合物可以包括共价连接在任何位点的前药部分。
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公开(公告)号：US20090227491A1
公开(公告)日：2009-09-10
申请号：US12303219
申请日：2007-07-06
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyung-Jung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyung-Jung Pyun , Xiaoning C. Sheng , Jianying Wang
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20110082112A1
公开(公告)日：2011-04-07
申请号：US12913704
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： A61K31/675 , A61P31/14
CPC分类号： C07F9/65583
摘要： The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound.
摘要翻译： 本发明涉及通过向个体施用包含治疗有效量的抗病毒次膦酸盐化合物的药物组合物来治疗与丙型肝炎相关的疾病的方法。
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公开(公告)号：US07893264B2
公开(公告)日：2011-02-22
申请号：US11825606
申请日：2007-07-06
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： C07D221/18 , C07F9/02 , A61K38/12
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20110081314A1
公开(公告)日：2011-04-07
申请号：US12913692
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： A61K38/21 , C07D245/04 , A61K31/675 , A61K31/70 , A61K31/7056 , A61K31/7068 , A61P31/14
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US08674088B2
公开(公告)日：2014-03-18
申请号：US12913692
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： C07D487/00
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US08586744B2
公开(公告)日：2013-11-19
申请号：US12913704
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： C07D221/18 , C07F9/02 , A61K38/12
CPC分类号： C07F9/65583
摘要： The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound.
摘要翻译： 本发明涉及通过向个体施用包含治疗有效量的抗病毒次膦酸盐化合物的药物组合物来治疗与丙型肝炎相关的疾病的方法。
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