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    Pre-organized tricyclic integrase inhibitor compounds
    3.
    发明申请
    Pre-organized tricyclic integrase inhibitor compounds 审中-公开
    预先组织的三环整合酶抑制剂化合物

    公开(公告)号：US20060217410A1

    公开(公告)日：2006-09-28

    申请号：US10529269

    申请日：2003-10-16

    Applicant: James Chen ,  Xiaowu Chen ,  Maria Fardis ,  Haolun Jin ,  Choung Kim ,  Laura Schacherer

    Inventor： James Chen ,  Xiaowu Chen ,  Maria Fardis ,  Haolun Jin ,  Choung Kim ,  Laura Schacherer

    IPC: C07D471/14 ,  A61K31/4745

    CPC classification number: C07D471/04 ,  C07D471/14

    Abstract: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. Formula (I). A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.

    Abstract translation: 公开了根据以下结构的三环化合物，其受保护的中间体和用于抑制HIV整合酶的方法。 式（I）。 A 1和A 2是形成五，六或七元环的部分。 L是连接Ar与N的环原子的键或连接体.X是O，S或取代的氮。 Ar是芳基或杂芳基。 Q是N， + NR，或CR 4。 芳基碳可以独立地被除氢以外的取代基取代。 化合物可以包括共价连接在任何位点的前药部分。

    Anti-proliferative compounds, compositions, and methods of use thereof
    4.
    发明申请
    Anti-proliferative compounds, compositions, and methods of use thereof 审中-公开

    公开(公告)号：US20060030545A1

    公开(公告)日：2006-02-09

    申请号：US11170247

    申请日：2005-06-29

    Applicant: Xiaoqin Cheng ,  Gary Cook ,  Manoj Desai ,  Edward Doerffler ,  Gong-Xin He ,  Choung Kim ,  William Lee ,  John Rohloff ,  Jianying Wang ,  Zheng-Yu Yang

    Inventor： Xiaoqin Cheng ,  Gary Cook ,  Manoj Desai ,  Edward Doerffler ,  Gong-Xin He ,  Choung Kim ,  William Lee ,  John Rohloff ,  Jianying Wang ,  Zheng-Yu Yang

    IPC: A61K31/675 ,  C07F9/6512

    CPC classification number: C07F9/65616 ,  Y02P20/55

    Abstract: Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 is RX; RX2 is alkenyl of 2 to 18 carbon atoms or alkynyl of 2 to 18 carbon atoms; Y1 is ═O, —O(RX), ═S, —N(RX), —N(O)(RX), —N(ORX), —N(O)(ORX), or —N(N(RX)(RX)); RX is independently R1, R2, R4, W3, or a protecting group; R1 is independently —H or alkyl of 1 to 18 carbon atoms; R2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is —H, —F, —Cl, —Br, —I, —CF3, —CN, N3, —NO2, or —OR4; R3b is ═O, —O(R4), ═S, —N(R4), —N(O)(R4), —N(OR4), —N(O)(OR4), or —N(N(R4)(R4)); R3c is —R4, —N(R4)(R4), —SR4, —S(O)R4, —S(O)2R4, —S(O)(OR4), —S(O)2(OR4), —OC(R3b)R4, —OC(R3b)OR4, —OC(R3b)(N(R4)(R4)), —SC(R3b)R4, —SC(R3b)OR4, —SC(R3b)(N(R4)(R4)), —N(R4)C(R3b)R4, —N(R4)C(R3b)OR4, —N(R4)C(R3b)(N(R4)(R4)), W3 or —R5W3; R3d is —C(R3b)R4, —C(R3b)OR4, —C(R3b)W3, —C(R3b)OW3 or —C(R3b)(N(R4)(R4)); R4 is —H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W3 is W4 or W5; W4 is R6, —C(R3b)R6, —C(R3b)W5, —SOM2R6, or —SOM2W5, wherein R6 is R4 wherein each R4 is substituted with 0 to 3 R3 groups; W5 is carbocycle or heterocycle wherein W5 is independently substituted with 0 to 3 R2 groups; and M2 is 0, 1 or 2; or pharmaceutically acceptable salts thereof.

    SYSTEM FOR AND METHOD OF MANAGING WORKLOADS IN A DATABASE SYSTEM
    6.
    发明申请
    SYSTEM FOR AND METHOD OF MANAGING WORKLOADS IN A DATABASE SYSTEM 审中-公开
    在数据库系统中管理工作负载的系统和方法

    公开(公告)号：US20080133608A1

    公开(公告)日：2008-06-05

    申请号：US11566734

    申请日：2006-12-05

    Applicant: Douglas Brown ,  Choung Kim ,  Anita Richards

    Inventor： Douglas Brown ,  Choung Kim ,  Anita Richards

    IPC: G06F17/30

    CPC classification number: G06F9/5083 ,  G06F2209/5022

    Abstract: A system for and method of managing database workloads. The workload managing system comprises a historical data collector arranged to collect historical data indicative of historical database performance trends, and a current data collector arranged to collect substantially current data indicative of substantially current database performance. The system is arranged to compare the collected historical data with the collected substantially current data and to modify operation of the database based on the comparison.

    Abstract translation: 用于管理数据库工作负载的系统和方法。 工作负载管理系统包括历史数据收集器，其被布置成收集指示历史数据库性能趋势的历史数据，以及当前数据收集器，其被布置为收集指示基本上当前数据库性能的基本上当前的数据。 该系统被安排为将收集的历史数据与收集的基本上当前的数据进行比较，并且基于该比较来修改数据库的操作。

    Antiviral compounds
    9.
    发明申请
    Antiviral compounds 审中-公开
    抗病毒化合物

    公开(公告)号：US20070072809A1

    公开(公告)日：2007-03-29

    申请号：US11487542

    申请日：2006-07-14

    Applicant: Aesop Cho ,  Choung Kim ,  Xiaoning Sheng

    Inventor： Aesop Cho ,  Choung Kim ,  Xiaoning Sheng

    IPC: C07K5/06 ,  A61K38/05

    CPC classification number: C07D417/14 ,  A61K38/21 ,  C07F9/572 ,  C07K5/0812 ,  A61K2300/00

    Abstract: The invention is related to HCV inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

    Abstract translation: 本发明涉及HCV抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

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