公开(公告)号：US20050215513A1

公开(公告)日：2005-09-29

申请号：US10832815

申请日：2004-04-26

Applicant: Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Haolun Jin ,  Ralph Hirschmann ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Christopher Lee ,  William Lee ,  Richard MacKman ,  David Markevitch ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Rosemarie Sherlock ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang

Inventor： Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Haolun Jin ,  Ralph Hirschmann ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Christopher Lee ,  William Lee ,  Richard MacKman ,  David Markevitch ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Rosemarie Sherlock ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang

IPC: A61K31/662 ,  A61K31/675 ,  A61K31/7072 ,  A61K31/7076 ,  C07D205/04 ,  C07D211/58 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07F9/40 ,  C07F9/572 ,  C07F9/58 ,  C07F9/60 ,  C07F9/6503 ,  C07F9/6509 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/655 ,  C07F9/6553 ,  C07F9/6561

CPC classification number: C07F9/65616 ,  A61K31/662 ,  A61K31/7072 ,  A61K31/7076 ,  A61K47/548 ,  C07D205/04 ,  C07D211/58 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07F9/4075 ,  C07F9/5728 ,  C07F9/58 ,  C07F9/60 ,  C07F9/65031 ,  C07F9/650905 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655354 ,  C07F9/6561 ,  C07H15/00 ,  C07H17/00 ,  C07H19/056 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  Y02A50/393 ,  Y02A50/465

Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20080039427A1

公开(公告)日：2008-02-14

申请号：US11803822

申请日：2007-05-16

Applicant: Adrian Ray ,  Daniel Tumas ,  Hans Reiser ,  William Watkins ,  William Lee ,  Lee Chong

Inventor： Adrian Ray ,  Daniel Tumas ,  Hans Reiser ,  William Watkins ,  William Lee ,  Lee Chong

IPC: A61K31/675 ,  A61P35/00 ,  A61P35/02 ,  C07F9/46

CPC classification number: C07F9/65616

Abstract: A compound of formula 1 and/or its salts, tautomers or solvates is used to treat hematological malignancies. In an embodiment, an organic acid salt of compound 1 is provided for general use in treatment of neoplasms, and in a further embodiment the salt is stabilized with carbohydrate.

Abstract translation: 式1化合物和/或其盐，互变异构体或溶剂合物用于治疗血液恶性肿瘤。 在一个实施方案中，提供化合物1的有机酸盐，用于一般用于治疗赘生物，并且在另一个实施方案中，所述盐用碳水化合物稳定。

公开(公告)号：US20060264404A1

公开(公告)日：2006-11-23

申请号：US11258621

申请日：2005-10-25

Applicant: Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Manoj Desai ,  Maria Fardis ,  Craig Gibbs ,  Ralph Hirschmann ,  Alan Huang ,  Haolun Jin ,  Choung Kim ,  Thorsten Kirschberg ,  Steven Krawczyk ,  Christopher Lee ,  William Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Peter Nelson ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Rosemarie Sherlock ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang ,  Lijun Zhang

Inventor： Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Manoj Desai ,  Maria Fardis ,  Craig Gibbs ,  Ralph Hirschmann ,  Alan Huang ,  Haolun Jin ,  Choung Kim ,  Thorsten Kirschberg ,  Steven Krawczyk ,  Christopher Lee ,  William Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Peter Nelson ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Rosemarie Sherlock ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang ,  Lijun Zhang

IPC: A61K31/675 ,  C07F9/6512

CPC classification number: C07F9/65616 ,  C07F9/4006 ,  C07F9/4465 ,  C07F9/5304 ,  C07F9/650952 ,  C07F9/653 ,  C07F9/65507 ,  C07F9/65515 ,  C07F9/65517 ,  C07F9/65583 ,  C07F9/65586 ,  C07F9/6561

Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.

Abstract translation: 本发明涉及磷取代的治疗剂，含有这种磷取代剂的组合物，以及包括施用这种磷取代剂的治疗方法，以及可用于制备这种药剂的方法和中间体。

公开(公告)号：US20060199788A1

公开(公告)日：2006-09-07

申请号：US10833294

申请日：2004-04-26

Applicant: Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Craig Gibbs ,  Ralph Hirschmann ,  Thorsten Kirschberg ,  Christopher Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  Peter Nelson ,  David Oare ,  Hyung-Jung Pyun ,  Adrian Ray ,  Rosemarie Sherlock ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang

Inventor： Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Craig Gibbs ,  Ralph Hirschmann ,  Thorsten Kirschberg ,  Christopher Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  Peter Nelson ,  David Oare ,  Hyung-Jung Pyun ,  Adrian Ray ,  Rosemarie Sherlock ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang

IPC: A61K31/66 ,  C07F9/02

CPC classification number: C07F9/65583 ,  A61K31/60 ,  A61K47/548 ,  C07F9/4006 ,  C07F9/4021 ,  C07F9/46 ,  C07F9/572 ,  C07F9/5728 ,  C07F9/65031 ,  C07F9/65038 ,  C07F9/650905 ,  C07F9/6524 ,  C07F9/653 ,  C07F9/65515 ,  C07F9/65517 ,  C07F9/65586 ,  C07F9/6561 ,  C07F9/65616

Abstract: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗炎化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20070049754A1

公开(公告)日：2007-03-01

申请号：US11190225

申请日：2005-07-26

Applicant: Constantine Boojamra ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Oleg Petrakovsky ,  Adrian Ray ,  Lijun Zhang

Inventor： Constantine Boojamra ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Oleg Petrakovsky ,  Adrian Ray ,  Lijun Zhang

IPC: C07F9/6512

CPC classification number: C07H19/16 ,  A61K31/341 ,  A61K31/513 ,  A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65616 ,  C07H19/00 ,  C07H19/20 ,  A61K2300/00

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20070027113A1

公开(公告)日：2007-02-01

申请号：US10832816

申请日：2004-04-26

Applicant: James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Thorsten Kirschberg ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins

Inventor： James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Thorsten Kirschberg ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins

IPC: A61K31/675 ,  A61K31/519

CPC classification number: A61K31/519 ,  A61K31/662 ,  A61K31/675 ,  A61K47/54 ,  A61K47/548

Abstract: The invention is related to phosphorus substituted purine nucleoside phosphorylase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的嘌呤核苷磷酸化酶抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20060079478A1

公开(公告)日：2006-04-13

申请号：US10833293

申请日：2004-04-26

Applicant: Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Steven Krawczyk ,  Christopher Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Peter Nelson ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang ,  Lijun Zhang

Inventor： Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Steven Krawczyk ,  Christopher Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Peter Nelson ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang ,  Lijun Zhang

IPC: A61K31/7076 ,  A61K31/7072 ,  C07H19/04 ,  A61K31/675

CPC classification number: A61K31/7076 ,  A61K31/675 ,  A61K31/7072 ,  A61K47/548 ,  C07H19/04

Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20060035866A1

公开(公告)日：2006-02-16

申请号：US10833295

申请日：2004-04-26

Applicant: Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Manoj Desai ,  Maria Fardis ,  Alan Huang ,  Thorsten Kirschberg ,  Christopher Lee ,  Richard Mackman ,  Peter Nelson ,  Hyung-Jung Pyun ,  Adrian Ray ,  William Watkins ,  Jennifer Zhang ,  Sundaramoorthi Swaminathan

Inventor： Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Manoj Desai ,  Maria Fardis ,  Alan Huang ,  Thorsten Kirschberg ,  Christopher Lee ,  Richard Mackman ,  Peter Nelson ,  Hyung-Jung Pyun ,  Adrian Ray ,  William Watkins ,  Jennifer Zhang ,  Sundaramoorthi Swaminathan

IPC: A61K31/66

CPC classification number: A61K47/548 ,  A61K47/542

Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及具有免疫调节活性的膦酸酯取代的化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20050261237A1

公开(公告)日：2005-11-24

申请号：US10832810

申请日：2004-04-26

Applicant: Constantine Boojamra ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Christopher Lee ,  David Oare ,  Vidya Prasad ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins

Inventor： Constantine Boojamra ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Christopher Lee ,  David Oare ,  Vidya Prasad ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins

IPC: A61K31/675 ,  A61K31/7072 ,  A61K31/7076

CPC classification number: C07F9/65616 ,  C07F9/65586 ,  C07F9/6561 ,  C07H7/04 ,  C07H19/056 ,  C07H19/06 ,  C07H19/14 ,  C07H19/173

Abstract: The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的核苷化合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。