公开(公告)号：US20050215525A1

公开(公告)日：2005-09-29

申请号：US10833291

申请日：2004-04-26

Applicant: Constantine Boojamra ,  Aesop Cho ,  William Watkins

Inventor： Constantine Boojamra ,  Aesop Cho ,  William Watkins

IPC: A61K31/675 ,  A61K47/48

CPC classification number: C07F9/4006 ,  A61K47/548 ,  C07F9/58 ,  C07F9/650952 ,  C07F9/65583 ,  C07F9/65586 ,  C07F9/6561

Abstract: The invention is related to phosphorus substituted anti-infective compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗感染化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20050215513A1

公开(公告)日：2005-09-29

申请号：US10832815

申请日：2004-04-26

Applicant: Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Haolun Jin ,  Ralph Hirschmann ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Christopher Lee ,  William Lee ,  Richard MacKman ,  David Markevitch ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Rosemarie Sherlock ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang

Inventor： Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Haolun Jin ,  Ralph Hirschmann ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Christopher Lee ,  William Lee ,  Richard MacKman ,  David Markevitch ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Rosemarie Sherlock ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang

IPC: A61K31/662 ,  A61K31/675 ,  A61K31/7072 ,  A61K31/7076 ,  C07D205/04 ,  C07D211/58 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07F9/40 ,  C07F9/572 ,  C07F9/58 ,  C07F9/60 ,  C07F9/6503 ,  C07F9/6509 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/655 ,  C07F9/6553 ,  C07F9/6561

CPC classification number: C07F9/65616 ,  A61K31/662 ,  A61K31/7072 ,  A61K31/7076 ,  A61K47/548 ,  C07D205/04 ,  C07D211/58 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07F9/4075 ,  C07F9/5728 ,  C07F9/58 ,  C07F9/60 ,  C07F9/65031 ,  C07F9/650905 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655354 ,  C07F9/6561 ,  C07H15/00 ,  C07H17/00 ,  C07H19/056 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  Y02A50/393 ,  Y02A50/465

Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20060264404A1

公开(公告)日：2006-11-23

申请号：US11258621

申请日：2005-10-25

Applicant: Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Manoj Desai ,  Maria Fardis ,  Craig Gibbs ,  Ralph Hirschmann ,  Alan Huang ,  Haolun Jin ,  Choung Kim ,  Thorsten Kirschberg ,  Steven Krawczyk ,  Christopher Lee ,  William Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Peter Nelson ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Rosemarie Sherlock ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang ,  Lijun Zhang

Inventor： Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Manoj Desai ,  Maria Fardis ,  Craig Gibbs ,  Ralph Hirschmann ,  Alan Huang ,  Haolun Jin ,  Choung Kim ,  Thorsten Kirschberg ,  Steven Krawczyk ,  Christopher Lee ,  William Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Peter Nelson ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Rosemarie Sherlock ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang ,  Lijun Zhang

IPC: A61K31/675 ,  C07F9/6512

CPC classification number: C07F9/65616 ,  C07F9/4006 ,  C07F9/4465 ,  C07F9/5304 ,  C07F9/650952 ,  C07F9/653 ,  C07F9/65507 ,  C07F9/65515 ,  C07F9/65517 ,  C07F9/65583 ,  C07F9/65586 ,  C07F9/6561

Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.

Abstract translation: 本发明涉及磷取代的治疗剂，含有这种磷取代剂的组合物，以及包括施用这种磷取代剂的治疗方法，以及可用于制备这种药剂的方法和中间体。

公开(公告)号：US20070049754A1

公开(公告)日：2007-03-01

申请号：US11190225

申请日：2005-07-26

Applicant: Constantine Boojamra ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Oleg Petrakovsky ,  Adrian Ray ,  Lijun Zhang

Inventor： Constantine Boojamra ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Oleg Petrakovsky ,  Adrian Ray ,  Lijun Zhang

IPC: C07F9/6512

CPC classification number: C07H19/16 ,  A61K31/341 ,  A61K31/513 ,  A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65616 ,  C07H19/00 ,  C07H19/20 ,  A61K2300/00

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20080107628A1

公开(公告)日：2008-05-08

申请号：US11825395

申请日：2007-07-06

Applicant: Constantine Boojamra ,  James Chen ,  Alan Huang ,  Choung Kim ,  Kuei-Ying Lin ,  Richard Mackman ,  David Oare ,  Jason Perry ,  Oliver Saunders ,  Sundaramoorthi Swaminathan ,  Lijun Zhang

Inventor： Constantine Boojamra ,  James Chen ,  Alan Huang ,  Choung Kim ,  Kuei-Ying Lin ,  Richard Mackman ,  David Oare ,  Jason Perry ,  Oliver Saunders ,  Sundaramoorthi Swaminathan ,  Lijun Zhang

IPC: A61K38/21 ,  C07F9/02 ,  A61K31/675 ,  A61P31/00

CPC classification number: C07H19/00

Abstract: A compound of Formula I, Formula II, Formula III, or Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, therapeutic compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Abstract translation: 式I，式II，式III或式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的治疗组合物，以及包括施用这些化合物的治疗方法。

公开(公告)号：US20060079478A1

公开(公告)日：2006-04-13

申请号：US10833293

申请日：2004-04-26

Applicant: Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Steven Krawczyk ,  Christopher Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Peter Nelson ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang ,  Lijun Zhang

Inventor： Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Steven Krawczyk ,  Christopher Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Peter Nelson ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang ,  Lijun Zhang

IPC: A61K31/7076 ,  A61K31/7072 ,  C07H19/04 ,  A61K31/675

CPC classification number: A61K31/7076 ,  A61K31/675 ,  A61K31/7072 ,  A61K47/548 ,  C07H19/04

Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20060014743A1

公开(公告)日：2006-01-19

申请号：US11211919

申请日：2005-08-25

Applicant: Constantine Boojamra ,  Lee Chong ,  Scott Hecker ,  Tomasz Glinka ,  Dale Shuster

Inventor： Constantine Boojamra ,  Lee Chong ,  Scott Hecker ,  Tomasz Glinka ,  Dale Shuster

IPC: A61K31/53 ,  A61K31/50 ,  A61K31/506

CPC classification number: C07D213/40 ,  A61K31/50 ,  A61K31/506 ,  A61K31/53 ,  C07C233/18 ,  C07C233/31 ,  C07C233/47 ,  C07C255/60 ,  C07C311/46 ,  C07C317/32 ,  C07C2601/02 ,  C07C2601/04 ,  C07D213/73 ,  C07D233/54 ,  C07D237/08 ,  C07D237/20 ,  C07D239/26 ,  C07D239/42 ,  C07D241/12 ,  C07D249/08 ,  C07D261/08 ,  C07D261/12 ,  C07D261/14 ,  C07D261/18 ,  C07D271/06 ,  C07D271/10 ,  C07D275/02 ,  C07D277/28 ,  C07D277/40 ,  C07D285/08 ,  C07D285/12 ,  C07D317/58 ,  C07D333/20 ,  Y02A50/475

Abstract: The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.

Abstract translation: 本发明涉及具有以下化学结构的新型氟苯尼考化合物：其中所述化合物可用于治疗和/或预防广泛范围的患者（例如但不限于鸟类，鱼类，贝类和哺乳动物）中的细菌感染。

公开(公告)号：US20050261237A1

公开(公告)日：2005-11-24

申请号：US10832810

申请日：2004-04-26

Applicant: Constantine Boojamra ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Christopher Lee ,  David Oare ,  Vidya Prasad ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins

Inventor： Constantine Boojamra ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Christopher Lee ,  David Oare ,  Vidya Prasad ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins

IPC: A61K31/675 ,  A61K31/7072 ,  A61K31/7076

CPC classification number: C07F9/65616 ,  C07F9/65586 ,  C07F9/6561 ,  C07H7/04 ,  C07H19/056 ,  C07H19/06 ,  C07H19/14 ,  C07H19/173

Abstract: The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的核苷化合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。