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公开(公告)号:US20110288053A1
公开(公告)日:2011-11-24
申请号:US13187293
申请日:2011-07-20
申请人: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Heolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoothi Swaninathan , William J. Watkins , Jenneifer Zhang
发明人: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Heolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoothi Swaninathan , William J. Watkins , Jenneifer Zhang
IPC分类号: A61K31/675 , A61K31/665 , A61K31/52 , A61K31/422 , C07D307/87 , A61P31/12 , C07F9/02 , C07D473/34 , C07D413/12 , C07F9/06 , C12N5/02 , A61K31/365
CPC分类号: C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及具有抗病毒活性的磷取代的化合物,含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US20090181930A1
公开(公告)日:2009-07-16
申请号:US12167038
申请日:2008-07-02
申请人: Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Thorsten Kirschberg , Richard L. Mackman , Sundaramoorthi Swaminathan , William J. Watkins
发明人: Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Thorsten Kirschberg , Richard L. Mackman , Sundaramoorthi Swaminathan , William J. Watkins
IPC分类号: C07F9/6512 , A61K31/675
CPC分类号: A61K31/662 , A61K47/54 , A61K47/548 , C07F9/58 , C07F9/6561
摘要: The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及磷取代的激酶抑制化合物,含有这些化合物的组合物,以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US20060264404A1
公开(公告)日:2006-11-23
申请号:US11258621
申请日:2005-10-25
申请人: Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Alan Huang , Haolun Jin , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , William Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
发明人: Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Alan Huang , Haolun Jin , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , William Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
IPC分类号: A61K31/675 , C07F9/6512
CPC分类号: C07F9/65616 , C07F9/4006 , C07F9/4465 , C07F9/5304 , C07F9/650952 , C07F9/653 , C07F9/65507 , C07F9/65515 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
摘要翻译: 本发明涉及磷取代的治疗剂,含有这种磷取代剂的组合物,以及包括施用这种磷取代剂的治疗方法,以及可用于制备这种药剂的方法和中间体。
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公开(公告)号:US20060199788A1
公开(公告)日:2006-09-07
申请号:US10833294
申请日:2004-04-26
申请人: Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Thorsten Kirschberg , Christopher Lee , Kuei-Ying Lin , Richard Mackman , Peter Nelson , David Oare , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang
发明人: Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Thorsten Kirschberg , Christopher Lee , Kuei-Ying Lin , Richard Mackman , Peter Nelson , David Oare , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang
CPC分类号: C07F9/65583 , A61K31/60 , A61K47/548 , C07F9/4006 , C07F9/4021 , C07F9/46 , C07F9/572 , C07F9/5728 , C07F9/65031 , C07F9/65038 , C07F9/650905 , C07F9/6524 , C07F9/653 , C07F9/65515 , C07F9/65517 , C07F9/65586 , C07F9/6561 , C07F9/65616
摘要: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及磷取代的抗炎化合物,含有这些化合物的组合物,以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US20060116356A1
公开(公告)日:2006-06-01
申请号:US11106363
申请日:2005-04-14
申请人: Zhenhong Cai , Xiaowu Chen , Maria Fardis , Salman Jabri , Haolun Jin , Choung Kim , Samuel Metobo , Michael Mish , Richard Pastor
发明人: Zhenhong Cai , Xiaowu Chen , Maria Fardis , Salman Jabri , Haolun Jin , Choung Kim , Samuel Metobo , Michael Mish , Richard Pastor
IPC分类号: A61K31/675 , C07F9/6544 , C07F9/6533
CPC分类号: A61K31/66 , A61K31/662 , A61K31/665 , A61K31/675 , A61K47/548 , C07D209/48 , C07D213/38 , C07D471/04 , C07D487/04 , C07F9/6561
摘要: Novel HIV integrase inhibitor compounds having at least one phosphonate group, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
摘要翻译: 公开了具有至少一个膦酸酯基团的新型HIV整合酶抑制剂化合物,其受保护的中间体以及用于抑制HIV整合酶的方法。
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公开(公告)号:US06194421B1
公开(公告)日:2001-02-27
申请号:US09000801
申请日:1997-12-30
申请人: Fred E. Cohen , James H. McKerrow , George L. Kenyon , Zhe Li , Xiaowu Chen , Baoqing Gong , Rongshi Li
发明人: Fred E. Cohen , James H. McKerrow , George L. Kenyon , Zhe Li , Xiaowu Chen , Baoqing Gong , Rongshi Li
IPC分类号: A61K31404
CPC分类号: A61K31/472 , A61K31/12 , A61K31/135 , A61K31/136 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/365 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/47 , A61K31/50 , A61K31/505 , A61K31/60 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/491
摘要: Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I A—X—B wherein A is a substituted or unsubstituted heteroaromatic ring system comprising one to three rings which binds to at least one of the S2, S1 and S1′ subsites; B is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which binds to at least one of the S1′, S1 and S2 subsites; and X is —C═C—C(═O)—. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria and other infectious diseases.
摘要翻译: 公开了通过抑制后生动物寄生虫蛋白酶的酶作用来治疗感染后生动物寄生虫的患者的组合物和方法,其中使用至少一种式I化合物,其中A是取代或未取代的杂芳环系统,其包含一至三个环 其结合S2,S1和S1'子集中的至少一个; B是取代或未取代的同位芳族环系统,其包含一至三个环,其与S1',S1和S2子集中的至少一个结合; 且X为-C = C-C(= O) - 。 这些组合物和方法在治疗血吸虫病,疟疾和其他传染病方面具有特别的用途。
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公开(公告)号:US08022083B2
公开(公告)日:2011-09-20
申请号:US12166076
申请日:2008-07-01
申请人: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号: A61K31/44 , C07D487/00
CPC分类号: C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及具有抗病毒活性的磷取代的化合物,含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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8.Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds 有权
标题翻译: HIV蛋白酶抑制剂化合物的膦酸酯类似物的细胞积累公开(公告)号:US07649015B2
公开(公告)日:2010-01-19
申请号:US10423496
申请日:2003-04-25
申请人: Murty N. Arimili , Xiaowu Chen , Maria Fardis , Gong-Xin He , Haolun Jin , Choung U. Kim , William A. Lee , Kuei-Ying Lin , Hongtao Liu , Richard L. Mackman , Michael L. Mitchell , Hyung-Jung Pyun , Mark Sparacino , Sundaramoorthi Swaminathan , Jianying Wang , Matthew A. Williams , Lianhong Xu , Zheng-Yu Yang , Richard H. Yu , Jiancun Zhang , Lijun Zhang
发明人: Murty N. Arimili , Xiaowu Chen , Maria Fardis , Gong-Xin He , Haolun Jin , Choung U. Kim , William A. Lee , Kuei-Ying Lin , Hongtao Liu , Richard L. Mackman , Michael L. Mitchell , Hyung-Jung Pyun , Mark Sparacino , Sundaramoorthi Swaminathan , Jianying Wang , Matthew A. Williams , Lianhong Xu , Zheng-Yu Yang , Richard H. Yu , Jiancun Zhang , Lijun Zhang
IPC分类号: A61K31/343 , C07F9/28
CPC分类号: A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
摘要翻译: 公开了具有用作治疗剂和其它工业目的的具有HIV蛋白酶抑制性质的膦酸酯取代的化合物。 组合物抑制HIV蛋白酶活性和/或可用于治疗AIDS和其它抗病毒感染以及用于检测HIV蛋白酶的测定。
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公开(公告)号:US20090275535A1
公开(公告)日:2009-11-05
申请号:US12166076
申请日:2008-07-01
申请人: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号: A61K31/675 , C07F9/6561 , A61P31/12
CPC分类号: C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及具有抗病毒活性的磷取代的化合物,含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US20090247488A1
公开(公告)日:2009-10-01
申请号:US12145611
申请日:2008-06-25
申请人: Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralp F. Hirschmann , Thorsten Kirschberg , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , Peter H. Nelson , David A. Oare , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人: Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralp F. Hirschmann , Thorsten Kirschberg , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , Peter H. Nelson , David A. Oare , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号: A61K31/675 , C07F9/28 , A61P29/00
CPC分类号: C07F9/65616 , A61K31/675 , A61K47/54 , C07D237/14 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/65038 , C07F9/6512 , C07F9/6524 , C07F9/653 , C07F9/65515 , C07F9/65517 , C07F9/65586 , C07F9/6561
摘要: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及磷取代的抗炎化合物,含有这些化合物的组合物,以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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