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公开(公告)号：US06867196B1
公开(公告)日：2005-03-15
申请号：US09330909
申请日：1999-06-11
申请人： Jon A. Wolff , Hans Herweijer , Larry F. Whitesell , Matthew R. Wolff , Sean D. Monahan , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
发明人： Jon A. Wolff , Hans Herweijer , Larry F. Whitesell , Matthew R. Wolff , Sean D. Monahan , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
CPC分类号： A61K48/0008 , A61K48/0075
摘要： A process for delivering a nucleic acid to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a nucleic acid to a blood vessel, which subsequently delivers the nucleic acid to the cardiac tissue cell. The nucleic acid can be DNA or RNA or plasmid DNA or viral. This process is for purposes of gene therapy, and research.
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公开(公告)号：US06627616B2
公开(公告)日：2003-09-30
申请号：US09447966
申请日：1999-11-23
申请人： Sean D. Monahan , Jon A. Wolff , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
发明人： Sean D. Monahan , Jon A. Wolff , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
IPC分类号： C12N1500
CPC分类号： C12N15/113 , A61K31/70 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/62 , A61K47/6455 , A61K48/00 , A61K48/0008 , A61K48/0041 , A61K48/0083 , C07H21/00 , C12N15/87 , C12N2320/32 , A61K2300/00
摘要： Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian vessel such as a tail vein or artery. Prior to insertion, subsequent to insertion, or concurrent with insertion the permeability of the vessel is increased thereby the genetic material is delivered to the parenchymal cell altering endogenous properties of the cell.
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33.发明授权公开(公告)号：US07208314B2
公开(公告)日：2007-04-24
申请号：US10083456
申请日：2002-02-26
IPC分类号： C12N5/00
CPC分类号： A61K48/0025 , A61K48/0008 , A61K48/0041 , A61K48/0075 , A61K48/0083
摘要： A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell.
摘要翻译： 关于使用pH敏感递送系统将期望的化合物（例如药物和核酸）递送到细胞中的系统。 该系统提供用于将化合物递送和释放到细胞中的组合物和方法。
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公开(公告)号：US07098032B2
公开(公告)日：2006-08-29
申请号：US11046590
申请日：2005-01-28
申请人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
发明人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
IPC分类号： C12N15/88
CPC分类号： C12N15/88 , A61K47/60 , A61K47/645
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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公开(公告)号：US07098030B2
公开(公告)日：2006-08-29
申请号：US10899509
申请日：2004-07-26
申请人： David B. Rozema , Vladimir G. Budker , James E. Hagstrom , Vladimir Trubetskoy , Jon A. Wolff , Sean D. Monahan , Paul M. Slattum
发明人： David B. Rozema , Vladimir G. Budker , James E. Hagstrom , Vladimir Trubetskoy , Jon A. Wolff , Sean D. Monahan , Paul M. Slattum
IPC分类号： C12N15/88
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/645
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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公开(公告)号：US07033607B2
公开(公告)日：2006-04-25
申请号：US10095789
申请日：2002-03-11
申请人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
发明人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
IPC分类号： A61K9/127 , A61K31/713
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/87
摘要： A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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公开(公告)号：US07019113B2
公开(公告)日：2006-03-28
申请号：US10444662
申请日：2003-05-23
IPC分类号： C07K1/00
CPC分类号： C12N15/87 , A61K38/00 , A61K47/60 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07H21/00 , C07H21/04 , C07K7/06
摘要： An process for the reversible modification of membrane interaction of a compound is described. Modification of membrane interaction can be used to facilitate delivery of molecules to cells in vitro and in vivo. The described modifiers, which are used to reversibly inactivate the membrane active compounds, can also be utilized as cross-linkers or to reverse the charge of a molecule.
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38.发明授权公开(公告)号：US07482160B2
公开(公告)日：2009-01-27
申请号：US11322419
申请日：2005-12-30
申请人： Sean D. Monahan , David B. Rozema , Vladimir Trubetskoy , Paul M. Slattum , Jon A. Wolff , Vladimir G. Budker , James E. Hagstrom , Lisa J. Hanson
发明人： Sean D. Monahan , David B. Rozema , Vladimir Trubetskoy , Paul M. Slattum , Jon A. Wolff , Vladimir G. Budker , James E. Hagstrom , Lisa J. Hanson
IPC分类号： C12N15/88
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： A method of forming polymers in the presence of nucleic acid using template polymerization. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
摘要翻译： 使用模板聚合在核酸存在下形成聚合物的方法。 这些方法可用于递送核酸，用于冷凝核酸，用于形成核酸结合聚合物，用于形成含有核酸和聚合物的超分子复合物，并用于形成内聚电解质络合物。
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公开(公告)号：US07138382B2
公开(公告)日：2006-11-21
申请号：US10619778
申请日：2003-07-15
IPC分类号： A61K48/00 , A61K31/711 , A61K31/7105 , A61K38/04 , C12N15/87 , A61K9/127
CPC分类号： C12N15/87 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07H21/00 , C07H21/04 , C07K7/06
摘要： A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell.
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公开(公告)号：US06936729B2
公开(公告)日：2005-08-30
申请号：US09795607
申请日：2001-02-28
IPC分类号： A61K48/00 , C07C323/60 , C07C323/62 , C07D207/46 , C11D1/60 , A61K9/127 , C12N15/88
CPC分类号： C07D207/46 , A61K48/00 , C07C323/60 , C07C323/62
摘要： A labile disulfide-containing compound under physiological conditions, comprising: the disulfide-containing compound having a labile disulfide bond that is either a disulfide bond that is cleaved more rapidly than oxidized glutathione or a disulfide bond constructed from thiols in which one of the constituent thiols has a lower pKa than glutathione or a disulfide bond that is activated by intramolecular attack from a free thiol.
摘要翻译： 在生理条件下的不稳定二硫化物化合物，其包含：具有不稳定二硫键的二硫键化合物，其是比氧化型谷胱甘肽更快地裂解的二硫键或由其中一种组成硫醇组成的硫醇构成的二硫键 具有比谷胱甘肽低的pKa或通过游离硫醇的分子内攻击而活化的二硫键。
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