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公开(公告)号：US20080090882A1
公开(公告)日：2008-04-17
申请号：US11665854
申请日：2005-04-04
申请人： Dieter Dorsch , Rolf Gericke , Werner Mederski , Norbert Beier , Florian Lang
发明人： Dieter Dorsch , Rolf Gericke , Werner Mederski , Norbert Beier , Florian Lang
IPC分类号： A61K31/426 , A61K31/34 , A61K31/415 , C07D231/56 , C07D277/20 , C07D307/34 , C07D263/30 , A61P3/00 , A61K31/421
CPC分类号： A61K31/421 , A61K31/341 , A61K31/416 , A61K31/4178 , A61K31/422 , C07D231/56 , C07D233/54 , C07D233/68 , C07D263/34 , C07D277/56 , C07D307/34 , C07D307/68 , C07D333/38 , C07D413/00 , C07D413/02
摘要： Novel heterocyclic compounds of the formula (I), in which R1, D, W, T and T′ have the meanings indicated in Claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in fibroses and inflammatory processes of any type.
摘要翻译： 式（I）的新型杂环化合物，其中R 1，D，W，T和T'具有权利要求1所示的含义，是SGK抑制剂，可用于治疗SGK 引起的疾病和病症，例如糖尿病，肥胖症，代谢综合征（血脂异常），全身和肺高血压，心血管疾病和肾脏疾病，通常在任何类型的纤维和炎症过程中。
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公开(公告)号：US20070265259A1
公开(公告)日：2007-11-15
申请号：US11576226
申请日：2005-09-16
IPC分类号： A61K31/5377 , A61P29/00 , A61P35/00 , A61P35/04 , A61P9/00 , C07D413/14
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： Novel compounds of the formula (I), in which X, Y, R1, R2, R3, R4 and n have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 新的式（I）化合物，其中X，Y，R 1，R 2，R 3，R 4， n具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和用于治疗肿瘤。
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公开(公告)号：US07273867B2
公开(公告)日：2007-09-25
申请号：US10466680
申请日：2001-12-05
申请人： Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Bertram Cezanne , Johannes Gleitz , Christopher Barnes
发明人： Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Bertram Cezanne , Johannes Gleitz , Christopher Barnes
IPC分类号： A61K31/535 , A61K31/497 , A61K31/445 , A61K31/44 , A61K31/41
CPC分类号： C07D295/13 , A61K31/165 , A61K31/40 , A61K31/4166 , A61K31/4412 , A61K31/45 , A61K31/495 , A61K31/50 , A61K31/5375 , A61K31/545 , C07C257/18 , C07D207/26 , C07D211/76 , C07D213/64 , C07D263/24 , C07D265/32 , C07D295/135 , Y02P20/55
摘要： Novel compounds of the formula I in which W, X, Y, T, R1 and R2 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders
摘要翻译： 其中W，X，Y，T，R 1和R 2如式2中定义的式I的新化合物如专利权利要求1中所定义，是凝血因子Xa和 可用于预防和/或治疗血栓栓塞性疾病
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公开(公告)号：US20070185189A1
公开(公告)日：2007-08-09
申请号：US10583094
申请日：2004-11-26
IPC分类号： A61K31/4015 , C07D207/04
CPC分类号： C07D207/16 , C07D401/12
摘要： Novel compounds of the formula (I), in which R, R1, R2, R3, X, X′ and Y have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中R 1，R 2，R 2，R 3，X，X'和Y的新型式（I）化合物具有 专利权利要求1中所示的含义是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和用于治疗肿瘤。
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公开(公告)号：US20070161623A1
公开(公告)日：2007-07-12
申请号：US10587855
申请日：2005-01-07
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/5375 , C07D413/02
CPC分类号： C07D265/32 , C07D213/64 , C07D413/12
摘要： Novel compounds of the formula (I), in which X—Y-D-E, R1, R2 and R3 have the meanings indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours
摘要翻译： 式（I）的新型化合物，其中XYDE，R 1，R 2和R 3 3具有专利权利要求1中所示的含义 是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤
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公开(公告)号：US20070135507A1
公开(公告)日：2007-06-14
申请号：US10594024
申请日：2005-03-04
IPC分类号： A61K31/4178 , A61K31/401 , C07D403/02
CPC分类号： C07D207/12 , C07D403/12
摘要： Novel compounds of the formula (I), in which R, R1, R2, R3 and R4 have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新型化合物，其中R 1，R 2，R 2，R 3和R 4， SUP>具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和用于治疗肿瘤。
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37.发明授权Derivatives of phenoxy-n-′4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors 失效苯氧基-n-4-（异噻唑啉茚-1,1-二氧杂-2-基）苯基缬氨酸酰胺和其他化合物作为凝血因子xa的抑制剂在治疗血栓栓塞性疾病和肿瘤中的衍生物公开(公告)号：US07199133B2
公开(公告)日：2007-04-03
申请号：US10495254
申请日：2002-10-10
申请人： Dieter Dorsch , Bertram Cezanne , Christos Tsaklakidis , Werner Mederski , Johannes Gleitz , Christopher Barnes
发明人： Dieter Dorsch , Bertram Cezanne , Christos Tsaklakidis , Werner Mederski , Johannes Gleitz , Christopher Barnes
IPC分类号： A61K31/47 , A61K31/41 , A61K31/425 , C07D217/22 , C07D271/06 , C07D275/02
CPC分类号： C07D275/02 , A61K31/425 , C07D417/12
摘要： Novel compounds of formula (I), wherein D, W, X, Y, T and R1 have the meanings cited in claim 1, are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors
摘要翻译： 式（I）的新型化合物，其中D，W，X，Y，T和R 1具有权利要求1中引用的含义，是凝血因子Xa的抑制剂，可用于预防和 /或治疗血栓栓塞性疾病和治疗肿瘤
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38.发明申请Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products 失效制备吡咯烷-1,2-二羧酸-1-（苯基（ - 酰胺））-2-（苯基（ - 酰胺））衍生物的方法和作为中间体的1-（苯基氨基甲酰基） - 吡咯烷-2-甲酸衍生物 产品公开(公告)号：US20060211692A1
公开(公告)日：2006-09-21
申请号：US10551670
申请日：2004-03-09
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： C07D207/16 , C07D413/12
摘要： Process for the preparation of compounds of the formula I in which R, R1, R2 and R3 are as defined in Patent claim 1, and compounds of the formula IV in which R and R1 are as defined in Patent claim 1, are intermediates for the preparation of the compounds of the formula I.
摘要翻译： R 1，R 2，R 2和R 3的化合物的制备方法如专利权利要求1中所定义 和其中R和R 1如权利要求1中所定义的式IV化合物是制备式I化合物的中间体。
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公开(公告)号：US20060183739A1
公开(公告)日：2006-08-17
申请号：US10551557
申请日：2004-03-08
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： C07D413/12 , C07D207/16 , C07D207/27 , C07D211/60 , C07D211/76 , C07D213/64 , C07D213/68 , C07D223/10 , C07D241/18 , C07D265/08 , C07D265/32 , C07D267/10 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/02 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Novel compounds of the formula (I), in which D, E, G, W, X, Y, T, R1 and R2 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新型化合物，其中D，E，G，W，X，Y，T，R 1和R 2如专利权利要求中所定义 1是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20060052376A1
公开(公告)日：2006-03-09
申请号：US10535246
申请日：2003-10-30
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Hanns Wurziger , Johannes Gleitz , Christoph Van Amsterdam
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Hanns Wurziger , Johannes Gleitz , Christoph Van Amsterdam
IPC分类号： C07D413/02 , A61K31/55 , A61K31/5377 , A61K31/4965 , A61K31/50
CPC分类号： C07D409/12 , C07D265/32 , C07D413/12
摘要： Novel compounds of the formula (I), in which D, W, X, Y, T, m and R1 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新型化合物，其中D，W，X，Y，T，m和R 1具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可以是 用于预防和/或治疗血栓栓塞性疾病和用于治疗肿瘤
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