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31.发明授权Heterocyclic alkynyl benzene compounds and medical compositions and uses thereof 有权杂环炔基苯化合物及其组合物及其用途公开(公告)号：US08846671B2
公开(公告)日：2014-09-30
申请号：US13807678
申请日：2011-06-03
申请人： Ke Ding , Deping Wang , Duanqing Pei , Zhang Zhang , Mengjie Shen , Kun Luo , Yubing Feng
发明人： Ke Ding , Deping Wang , Duanqing Pei , Zhang Zhang , Mengjie Shen , Kun Luo , Yubing Feng
IPC分类号： A61K31/535 , C07D401/00
CPC分类号： C07D487/04 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04
摘要： The heterocyclic alkynyl benzene compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in preparing drugs for preventing or treating tumors. The compounds can overcome the clinically induced resistance against Gleevec.
摘要翻译： 式（I）的杂环炔基苯化合物，其药学上可接受的盐和立体异构体，以及用于制备用于预防或治疗肿瘤的药物的应用。 这些化合物可以克服临床上对Gleevec的抵抗力。
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公开(公告)号：US08841263B2
公开(公告)日：2014-09-23
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20130017997A1
公开(公告)日：2013-01-17
申请号：US13365166
申请日：2012-02-02
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US20120252747A1
公开(公告)日：2012-10-04
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号： A61K31/7056 , C07H17/08 , A61P1/14 , A61P31/00 , A61P29/00 , A61P35/00 , C07H17/00 , A61K31/706
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US08202843B2
公开(公告)日：2012-06-19
申请号：US10590782
申请日：2005-02-25
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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36.发明授权公开(公告)号：US07335753B2
公开(公告)日：2008-02-26
申请号：US11359820
申请日：2006-02-21
申请人： Deping Wang , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Timothy S. McConnell , Joseph A. Ippolito , John N. Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
发明人： Deping Wang , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Timothy S. McConnell , Joseph A. Ippolito , John N. Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
IPC分类号： A61K31/7052 , A61K31/7048 , A61K31/4709 , A61K31/4176 , A61K31/4192 , A61K31/422 , C07H17/08 , C07D249/04 , C07D261/04 , C07D403/04 , C07D215/06
CPC分类号： A61K31/42 , A61K31/44 , A61K31/497 , A61K31/5375 , A61K31/7048 , C07H17/00
摘要： The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
摘要翻译： 本发明提供了一种可用作抗感染，抗增殖，抗炎和促动力的双功能杂环化合物。 本发明还提供了制备双官能杂环化合物的方法，以及使用这些化合物作为抗感染剂，抗增殖剂，抗炎剂和/或促动力剂的方法。
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公开(公告)号：US20080045585A1
公开(公告)日：2008-02-21
申请号：US10590782
申请日：2005-02-25
申请人： Jay Farmer , Ashoke Bhattacharjee , Yi Chen , Joel Goldberg , Joseph Ippolito , Zoltan Kanyo , Rongliang Lou , Adegboyega Oyelere , Edward Sherer , Joyce Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay Farmer , Ashoke Bhattacharjee , Yi Chen , Joel Goldberg , Joseph Ippolito , Zoltan Kanyo , Rongliang Lou , Adegboyega Oyelere , Edward Sherer , Joyce Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号： A61K31/335 , A61P43/00 , C07D269/00
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
摘要翻译： 本发明提供可用作治疗剂的大环化合物。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US06969726B2
公开(公告)日：2005-11-29
申请号：US10859476
申请日：2004-06-02
申请人： Rongliang Lou , Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人： Rongliang Lou , Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号： A61K31/421 , A61K31/4439 , A61K31/497 , A61K31/501 , C07D255/02 , C07D257/04 , C07D263/20 , C07D263/32 , C07D263/38 , C07D403/10 , C07D413/02 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D473/00 , C07D487/04
CPC分类号： C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
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39.发明申请公开(公告)号：US20050197334A1
公开(公告)日：2005-09-08
申请号：US10671326
申请日：2003-09-25
申请人： Deping Wang , Joyce Sutcliffe , Adegboyega Oyelere , Timothy McConnell , Joseph Ippolito , John Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
发明人： Deping Wang , Joyce Sutcliffe , Adegboyega Oyelere , Timothy McConnell , Joseph Ippolito , John Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
IPC分类号： A61P31/04 , C07D413/02 , C07D417/02 , C07H17/00 , C07D43/02
CPC分类号： A61K31/42 , A61K31/44 , A61K31/497 , A61K31/5375 , A61K31/7048 , C07H17/00
摘要： The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
摘要翻译： 本发明提供了一种可用作抗感染，抗增殖，抗炎和促动力的双功能杂环化合物。 本发明还提供了制备双官能杂环化合物的方法，以及使用这些化合物作为抗感染剂，抗增殖剂，抗炎剂和/或促动力剂的方法。
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公开(公告)号：US10421798B2
公开(公告)日：2019-09-24
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Volker Schellenberger , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
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