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公开(公告)号：US20150362493A1
公开(公告)日：2015-12-17
申请号：US14761690
申请日：2014-01-17
Applicant: DYAX CORP.
Inventor： Daniel J. Sexton , Ryan Faucette , Jon A. Kenniston , Gregory P. Conley , Andrew Nixon , Christopher TenHoor , Burt Adelman , Yung Chyung
IPC: G01N33/573 , C07K7/06 , C07K16/40
CPC classification number: G01N33/5735 , C07K7/06 , C07K16/36 , C07K16/40 , C07K2317/21 , C07K2317/76 , G01N2333/745 , G01N2800/065 , G01N2800/102 , G01N2800/52 , G01N2800/70
Abstract: The present disclosure provides methods of evaluating a subject, e.g., a subject at risk for or suffering from a pKal-mediated or bradykinin-mediated disorder, based on values (e.g., percentages) of intact and/or cleaved kininogen in a sample of the subject. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (KMA), or other diseases mediated by pKal useful in the evaluation and treatment. Such methods can involve the use of a detection agent that preferentially binds cleaved kininogen or intact kininogen.
Abstract translation: 本公开提供了评估受试者的方法，例如，基于pKal介导的或缓激肽介导的病症的风险或患有pKal介导的或缓激肽介导的病症的受试者，基于样品中完整和/或切割的激肽原的值（例如，百分比） 学科。 提供的方法允许对血浆激肽释放酶介导的血管性水肿（KMA）或由pKal介导的其它疾病的患者进行分析，其可用于评估和治疗。 这样的方法可以涉及使用优先结合切割的激肽原或完整激肽原的检测剂。
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公开(公告)号：US20140335023A1
公开(公告)日：2014-11-13
申请号：US14339053
申请日：2014-07-23
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Malini Viswanathan
CPC classification number: C07K16/40 , A61K49/0004 , A61K2039/505 , C07K2317/76 , C07K2317/92
Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.
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公开(公告)号：US10913802B2
公开(公告)日：2021-02-09
申请号：US15746048
申请日：2016-07-21
Applicant: Dyax Corp.
Inventor： Shauna Mason , Jon A. Kenniston , Andrew Nixon , Daniel J. Sexton , Stephen R. Comeau , Burt Adelman
Abstract: Disclosed herein are anti-Factor XIIa antibodies and methods of using such for treating diseases associated with Factor XII, including diseases associated with contact system activation, plasma prekallikrein signaling (e.g., hereditary angioedema), and ocular diseases.
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公开(公告)号：US10479834B2
公开(公告)日：2019-11-19
申请号：US15830998
申请日：2017-12-04
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Christopher TenHoor , Malini Viswanathan
Abstract: The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.
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公开(公告)号：US10428158B2
公开(公告)日：2019-10-01
申请号：US14669607
申请日：2015-03-26
Applicant: Dyax Corp.
Inventor： Gregory P. Conley , Andrew Nixon , Daniel J. Sexton
Abstract: Disclosed herein are compositions comprising one or more antibodies that specifically bind active plasma kallikrein (e.g., human plasma kallikrein) and methods of using such compositions for the treatment of retinal diseases, such as diabetic macular edema.
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Patent Agency Ranking
公开(公告)号：US20190241961A1
公开(公告)日：2019-08-08
申请号：US16333177
申请日：2017-09-15
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Malini Viswanathan , Ryan Faucette , Tripti Gaur
IPC: C12Q1/6883 , C12Q1/686 , C12Q1/6813 , C12Q1/6851
CPC classification number: C12Q1/6883 , C12Q1/6813 , C12Q1/6851 , C12Q1/686 , C12Q1/6876 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/502 , G01N2800/224
Abstract: Provided herein are methods and kits for analyzing a biological sample obtained from a subject having, suspected of having, or being at risk for a disease associated with the contact activation system.
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公开(公告)号：US20190120862A1
公开(公告)日：2019-04-25
申请号：US16131781
申请日：2018-09-14
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Burt Adelman , Andrew Nixon
IPC: G01N33/86 , G01N33/564
Abstract: Methods, kits and compositions for diagnosing and treating autoimmue diseases such as rheumatiodi arthritis, Crohn's disease, and ulcerative colitis.
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公开(公告)号：US20190002584A1
公开(公告)日：2019-01-03
申请号：US15746048
申请日：2016-07-21
Applicant: Dyax Corp.
Inventor： Shauna Mason , Jon A. Kenniston , Andrew Nixon , Daniel J. Sexton , Stephen R. Comeau , Burt Adelman
IPC: C07K16/36
Abstract: Disclosed herein are anti-Factor Xlla antibodies and methods of using such for treating diseases associated with Factor XII, including diseases associated with contact system activation, plasma prekallikrein signaling (e.g., hereditary angioedema), and ocular diseases.
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公开(公告)号：US20180037666A1
公开(公告)日：2018-02-08
申请号：US15706631
申请日：2017-09-15
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Malini Viswanathan
CPC classification number: C07K16/40 , A61K49/0004 , A61K2039/505 , C07K2317/76 , C07K2317/92
Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.
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公开(公告)号：US20180037664A1
公开(公告)日：2018-02-08
申请号：US15706613
申请日：2017-09-15
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Malini Viswanathan
CPC classification number: C07K16/40 , A61K49/0004 , A61K2039/505 , C07K2317/76 , C07K2317/92
Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.
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