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公开(公告)号：US09175074B2
公开(公告)日：2015-11-03
申请号：US14236859
申请日：2012-08-03
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.
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公开(公告)号：US20140199311A1
公开(公告)日：2014-07-17
申请号：US14236812
申请日：2012-08-03
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/732
摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising complementarity determining regions of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising complementarity determining regions of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the same as an active ingredient.
摘要翻译： 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 更具体地，本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的互补决定区的重链可变区和 包含SEQ ID NO：9,10和11的互补决定区的轻链可变区和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。
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公开(公告)号：US20140154261A1
公开(公告)日：2014-06-05
申请号：US14236859
申请日：2012-08-03
IPC分类号： C07K16/18 , A61K45/06 , A61K39/395
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.
摘要翻译： 本发明的目的是制备靶向癌细胞表面特异性表达的CAPRIN-1的抗体，对常规抗体具有优异的抗肿瘤活性，并提供抗体作为癌症治疗和/或预防剂的用途 。 本发明提供了靶向癌细胞表面特异表达的鉴定癌抗原蛋白的抗体作为癌症的治疗和/或预防剂的用途，特别是用于治疗和/或预防癌症的药物组合物，其包括作为 活性成分是与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体或其片段包含包含SEQ ID NO：5,6和7所代表的氨基酸序列的重链可变区和轻链 链可变区，其包含由SEQ ID NO：9,10和11表示的氨基酸序列。
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34.发明授权公开(公告)号：US08709418B2
公开(公告)日：2014-04-29
申请号：US13576955
申请日：2011-02-04
申请人： Fumiyoshi Okano , Takanori Saito
发明人： Fumiyoshi Okano , Takanori Saito
IPC分类号： A61K39/395 , C07K16/30 , A61K35/02
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3015 , C07K16/3053 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/732 , C07K2317/734
摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody comprising a heavy chain variable region that comprises SEQ ID NOS: 39, 40, and 41 and a light chain variable region that comprises SEQ ID NOS: 43, 44, and 45 or a fragment thereof as an active ingredient and having immunological reactivity with a CAPRIN-1 protein.
摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体而言，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含含有包含SEQ ID NO：39,40和41的重链可变区的抗体和包含SEQ ID NO：39,40和41的轻链可变区， NOS：43,44和45或其片段作为活性成分，并与CAPRIN-1蛋白具有免疫反应性。
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公开(公告)号：US20120064469A1
公开(公告)日：2012-03-15
申请号：US13221209
申请日：2011-08-30
申请人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
发明人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
CPC分类号： F27B17/0025 , H01L21/67109 , H01L21/67248
摘要： A heat treatment apparatus and control method enabling the apparatus to settle down the internal temperature of a treating vessel to a target temperature accurately and quickly. The apparatus includes a furnace body with a heater on an inner circumferential surface thereof, a treating vessel disposed inside the furnace body, a cooling medium supply blower and cooling medium release blower connected to the furnace body, and a temperature sensor provided inside the treating vessel. A signal from the temperature sensor is sent to a heater output computing unit of a controller. The computing unit determines a heater output level to be obtained during temperature regulation with the heater only, the heater output level being based on a preset temperature that has been determined by a temperature determining unit and temperature detected by the temperature sensor. A blower output computing unit activates blower output based on the heater output level.
摘要翻译： 一种热处理装置和控制方法，使得该装置能够准确而快速地将处理容器的内部温度降至目标温度。 该装置包括在炉体内部具有加热器的炉体，设置在炉体内的处理容器，与炉体连接的冷却介质供给鼓风机和冷却介质排出鼓风机，以及设置在处理容器内的温度传感器 。 来自温度传感器的信号被发送到控制器的加热器输出计算单元。 计算单元确定仅在加热器的温度调节期间获得的加热器输出水平，加热器输出水平基于由温度确定单元确定的预设温度和由温度传感器检测的温度。 鼓风机输出计算单元基于加热器输出电平激活鼓风机输出。
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公开(公告)号：US08128567B2
公开(公告)日：2012-03-06
申请号：US12342185
申请日：2008-12-23
申请人： Sei Kato , Takanori Saito
发明人： Sei Kato , Takanori Saito
摘要： An ultrasonic imaging apparatus includes an image obtaining unit for irradiating an imaging region and obtaining tomographic image information that draws the imaging region, an input unit for inputting scan parameter value information and a target sound pressure parameter value as an index of an estimated sound pressure in the subject, an estimated maximum sound pressure parameter value calculating device for calculating an estimated maximum sound pressure parameter value in the subject on the basis of the scan parameter value information and maximum drive voltage information of a piezoelectric transducer group for generating an ultrasonic wave, and a maximum drive voltage optimization device for comparing the estimated maximum sound pressure parameter value and the target sound pressure parameter value and optimizing the maximum drive voltage value of the maximum drive voltage information.
摘要翻译： 超声波成像装置包括图像获取单元，用于照射成像区域并获得绘制成像区域的断层图像信息;输入单元，用于输入扫描参数值信息和目标声压参数值作为估计声压的指标 所述被摄体，估计的最大声压参数值计算装置，用于根据用于产生超声波的压电换能器组的扫描参数值信息和最大驱动电压信息来计算被摄体中的估计最大声压参数值;以及 最大驱动电压优化装置，用于比较估计的最大声压参数值和目标声压参数值，并优化最大驱动电压信息的最大驱动电压值。
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公开(公告)号：US20110123492A1
公开(公告)日：2011-05-26
申请号：US13056122
申请日：2009-08-05
申请人： Fumiyoshi Okano , Masaki Shimizu , Takanori Saito
发明人： Fumiyoshi Okano , Masaki Shimizu , Takanori Saito
IPC分类号： A61K38/20 , C12N15/63 , C07K14/47 , A61K39/00 , A61K38/21 , C12N5/078 , C12N5/0783 , A61P35/00 , A61P37/04 , C07K7/06 , A61P35/02
CPC分类号： A61K39/0011 , A61K38/00 , A61K38/19 , A61K2039/53 , C07K14/47 , C07K14/4748 , C12N5/0634 , C12N5/0636 , A61K2300/00
摘要： The invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity that is selected from among polypeptides (a), (b), and (c): (a) a polypeptide of at least seven contiguous amino acids of the amino acid sequence shown by any even SEQ ID number selected from SEQ ID NOs: 2 to 30 listed in the Sequence Listing; (b) a polypeptide of at least seven amino acids having 90% or more sequence identity with the polypeptide (a); and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof, or a recombinant vector comprising a polynucleotide encoding said polypeptide and capable of expressing said polypeptide in vivo.
摘要翻译： 本发明涉及一种免疫诱导剂，其包含作为活性成分的至少一种具有免疫诱导活性的多肽，其选自多肽（a），（b）和（c）：（a）多肽 氨基酸序列的至少七个连续氨基酸由选自序列表中所列的SEQ ID NO：2至30的任何偶数SEQ ID号表示; （b）与多肽（a）具有90％或更多序列同一性的至少7个氨基酸的多肽; 以及（c）包含多肽（a）或（b）作为其部分序列的多肽，或包含编码所述多肽并能够在体内表达所述多肽的多核苷酸的重组载体。
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公开(公告)号：US06235821B1
公开(公告)日：2001-05-22
申请号：US09402250
申请日：1999-12-08
申请人： Takanori Saito
发明人： Takanori Saito
IPC分类号： C08K542
CPC分类号： C08L55/02 , B29C33/722 , B29C47/0011 , B29C47/0877 , C08K5/42 , C08L23/06 , C08L23/10 , C08L25/06 , C08L25/14 , C08L101/00 , C08L2205/02 , C09D133/12 , C08L33/12 , C08L2666/04 , C08L2666/02
摘要： The invention provides thermoplastic resin compositions for purging which comprise a thermoplastic resin and a methyl methacrylate/styrene copolymer incorporated therein. According to the invention, thermoplastic resin compositions for purging molding machines, which have an excellent cleaning ability, can be obtained.
摘要翻译： 本发明提供了包含热塑性树脂和其中加入的甲基丙烯酸甲酯/苯乙烯共聚物的用于清洗的热塑性树脂组合物。 根据本发明，可以获得具有优异的清洗能力的用于吹扫成型机的热塑性树脂组合物。
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公开(公告)号：US5426337A
公开(公告)日：1995-06-20
申请号：US753241
申请日：1991-08-30
CPC分类号： B21C37/104 , B21C37/108 , H02K5/04 , H02K5/15 , H02K7/081 , H02K7/1166 , H02K2205/03 , Y10T29/49009
摘要： A small-sized electric motor includes a yoke formed by bending a rectangular metallic plate into an oval shaped tube having a pair of flat parts and a pair of arcuate parts and joining opposite ends of the metallic plate. An end cap is secured on one end of the yoke and a gear casing is secured to the yoke by a tab formed on another end of the yoke. The joining faces of the metallic plate are located away from the center line of an arcuate part of the yoke and jagged faces are formed on the joining faces. The jagged faces are composed only of curved parts and straight parts having inclinations to the axis of the yoke. The end cap is secured by crimping a bendable tab formed on one end of the yoke by burring. A tab for securing the yoke to a gear box is formed by bending a tongue provided on the metallic plate together with notches on both sides of the tongue.
摘要翻译： 小型电动机包括通过将矩形金属板弯曲成具有一对扁平部分和一对弓形部分并且与金属板的相对端相连接的椭圆形管而形成的轭。 端盖固定在轭的一端，并且齿轮壳通过形成在轭的另一端上的突片固定到轭。 金属板的接合面远离轭的弓形部分的中心线，并且在接合面上形成锯齿状的面。 锯齿状的表面仅由弯曲部分和具有向轭的轴线倾斜的直线部分组成。 端盖通过卷边形成在轭的一端上的可弯曲接头来固定。 通过将设置在金属板上的舌片与舌头两侧的凹口一起弯曲来形成用于将轭固定到齿轮箱的突片。
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40.发明授权Percutaneous absorption promoter, a tape plaster and a method of promoting percutaneous absorpton 失效经皮吸收促进剂，胶带膏和促进经皮吸收剂的方法
公开(公告)号：US5413794A
公开(公告)日：1995-05-09
申请号：US937783
申请日：1992-09-01
申请人： Eiji Suzuki , Hideaki Okabe , Takanori Saito
发明人： Eiji Suzuki , Hideaki Okabe , Takanori Saito
IPC分类号： A61K9/70 , A61K47/18 , C07C229/56 , C07C233/54 , A61F13/00
CPC分类号： A61K9/7061 , A61K47/18 , A61K47/183 , A61K9/0014 , Y10S514/946 , Y10S514/947
摘要： A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above. The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.
摘要翻译： 经皮吸收促进剂包括其中氨基具有或不具有酰基取代基或烃取代基的氨基酸衍生物，羧基具有烃取代基，氨基和羧基之间的部分具有特定的结构 。 胶带包含上述经皮吸收促进剂。 该方法利用上述经皮吸收促进剂。 本发明的经皮促进剂具有优异的促进药理活性物质的经皮吸收和同时具有优异安全性的能力，能够通过循环系统快速将期望的药理活性物质快速递送至身体的所有部位， 用于治疗各种疾病。 包含它的胶带膏和利用它促进经皮吸收的方法具有相同的优点。
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