公开(公告)号：US20250101042A1

公开(公告)日：2025-03-27

申请号：US18825960

申请日：2024-09-05

Applicant: Gilead Sciences, Inc.

Inventor： Wilian Augusto Cortopassi Coelho ,  Chaodi Dai ,  Juan A. Guerrero ,  Hongyan Guo ,  Darryl Kato ,  Scott E. Lazerwith ,  Jonathan William Medley ,  Hyung-Jung Pyun ,  Maoqun Tian ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/55

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

公开(公告)号：US12227520B2

公开(公告)日：2025-02-18

申请号：US18050650

申请日：2022-10-28

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Scott D. Schroeder ,  Gregg M. Schwarzwalder ,  Nathan D. Shapiro ,  Devleena M. Shivakumar ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D498/18 ,  A61P31/18 ,  C07D471/18

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20240383922A1

公开(公告)日：2024-11-21

申请号：US18631866

申请日：2024-04-10

Applicant: Gilead Sciences, Inc.

Inventor： Wilian Augusto Cortopassi Coelho ,  Chaodi Dai ,  Katherine De La Fuente ,  Julie Farand ,  Juan A. Guerrero ,  Tezcan Guney ,  Hongyan Guo ,  Safaa S. Jamshed ,  Darryl Kato ,  Irene N. Kiburu ,  Scott E. Lazerwith ,  James B.C. Mack ,  Joshua L. Martin ,  Jessica L. McKinley ,  Jonathan William Medley ,  Hyung-Jung Pyun ,  Thomas P. Stratton ,  Rhiannon Thomas-Tran ,  Maoqun Tian ,  Vickie H. Tsui ,  William J. Watkins ,  Jie Xu ,  Adam D. Zajdlik ,  Jennifer R. Zhang

IPC: C07D519/00 ,  A61K31/553 ,  A61K45/06

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

公开(公告)号：US20240238285A1

公开(公告)日：2024-07-18

申请号：US18543923

申请日：2023-12-18

Applicant: Gilead Sciences, Inc.

Inventor： Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Hyung-Jung Pyun ,  Teresa Alejandra Trejo Martin

IPC: A61K31/4985 ,  C07D471/14 ,  C07D471/18

CPC classification number: A61K31/4985 ,  C07D471/14 ,  C07D471/18

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):




including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11883397B2

公开(公告)日：2024-01-30

申请号：US17532148

申请日：2021-11-22

Applicant: Gilead Sciences, Inc.

Inventor： Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Hyung-Jung Pyun ,  Teresa Alejandra Trejo Martin

IPC: A61K31/4985 ,  C07D487/22 ,  C07D471/18 ,  C07D471/14

CPC classification number: A61K31/4985 ,  C07D471/14 ,  C07D471/18

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):




including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20230087744A1

公开(公告)日：2023-03-23

申请号：US17671402

申请日：2022-02-14

Applicant: Gilead Sciences, Inc.

Inventor： Mingzhe Ji ,  Scott E. Lazerwith ,  Hyung-Jung Pyun

IPC: A61K31/4985 ,  A61K31/553 ,  C07D498/18 ,  A61K31/537 ,  C07D471/18 ,  A61K45/06 ,  C07D471/14 ,  C07D498/14

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20230027019A1

公开(公告)日：2023-01-26

申请号：US17361758

申请日：2021-06-29

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Scott D. Schroeder ,  Gregg M. Schwarzwalder ,  Nathan D. Shapiro ,  Devleena M. Shivakumar ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D498/18 ,  C07D471/18 ,  A61P31/18

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11548902B1

公开(公告)日：2023-01-10

申请号：US17361758

申请日：2021-06-29

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Scott D. Schroeder ,  Gregg M. Schwarzwälder ,  Nathan D. Shapiro ,  Devleena M. Shivakumar ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D498/18 ,  C07D471/18 ,  A61P31/18

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20220227787A1

公开(公告)日：2022-07-21

申请号：US17558130

申请日：2021-12-21

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Eda Y. Canales ,  Laurent P. Debien ,  Petr Jansa ,  Rick A. Lee ,  Jennifer A. Loyer-Drew ,  Stephane Perreault ,  Hyung-Jung Pyun ,  Roland D. Saito ,  Michael S. Sangi ,  Adam J. Schrier ,  Marina E. Shatskikh ,  James G. Taylor ,  Jennifer A. Treiberg ,  Joshua J. Van Veldhuizen ,  Lianhong Xu

IPC: C07D519/00

Abstract: The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

公开(公告)号：US20220135565A1

公开(公告)日：2022-05-05

申请号：US17489406

申请日：2021-09-29

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Hongyan Guo ,  Lan Jiang ,  Jiayao Li ,  David W. Lin ,  Hyung-Jung Pyun ,  Qiaoyin Wu ,  Hong Yang ,  Adam D. Zajdlik ,  Jennifer R. Zhang

IPC: C07D471/18 ,  A61P31/18 ,  C07D491/22

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof. Methods associated with the preparation and use of the disclosed compounds, as well as pharmaceutical compositions comprising such compounds are also disclosed.