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公开(公告)号：US20130245025A1
公开(公告)日：2013-09-19
申请号：US13733795
申请日：2013-01-03
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： C07D333/38 , C07D471/04 , C07D417/12 , C07D409/12 , C07D495/04 , C07D413/12 , C07D491/048
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US20120071516A1
公开(公告)日：2012-03-22
申请号：US13240548
申请日：2011-09-22
申请人： Jianguo Cao , Jeffrey P. Whitten , Yazhong Pei , Zhijun Wang , Evan Rogers , Jonathan Grey
发明人： Jianguo Cao , Jeffrey P. Whitten , Yazhong Pei , Zhijun Wang , Evan Rogers , Jonathan Grey
IPC分类号： A61K31/4439 , C07D401/14 , C07D417/14 , C07D277/64 , A61P3/14 , C07D293/06 , A61K31/4155 , A61K31/428 , A61K31/343 , A61K31/41 , C07D231/12 , C07D307/36
CPC分类号： C07D421/04 , C07D293/06 , C07D421/12 , C07D421/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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公开(公告)号：US20110263842A1
公开(公告)日：2011-10-27
申请号：US13000194
申请日：2008-06-23
申请人： Jinkui Xie , Anqiang Zhang , Jianguo Cao
发明人： Jinkui Xie , Anqiang Zhang , Jianguo Cao
IPC分类号： C08B37/02
CPC分类号： C08B37/0021 , C08B37/0003
摘要： Dextran for preparing medicine for anti-lung cancer, has repeated structure unit and molecular weight of 1.5-2.5 million Daltons. The dextran is extracted from land slug.
摘要翻译： 用于制备抗肺癌药物的葡聚糖，重复结构单元和分子量为1.5-2.5万道尔顿。 葡聚糖从土地中提取。
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公开(公告)号：US20110263612A1
公开(公告)日：2011-10-27
申请号：US13085324
申请日：2011-04-12
申请人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/497 , A61K31/44 , C07D405/10 , A61K31/4433 , C07D417/10 , A61K31/4439 , C07D401/10 , C07D413/10 , C07D413/14 , A61K31/444 , C07D471/04 , A61K31/437 , A61P29/00 , A61P13/12 , A61P11/00 , A61P1/00 , A61P19/02 , A61P19/10 , A61P37/06 , A61P25/00 , A61P17/06 , C07D213/75
CPC分类号： C07D213/74 , C07D213/75 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D493/10 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US20110166159A1
公开(公告)日：2011-07-07
申请号：US13050356
申请日：2011-03-17
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/497 , C07D409/04 , A61K31/381 , C07D401/04 , A61K31/4436 , C07D403/04 , A61K31/506 , A61K31/405 , A61K31/4184 , C07D417/14 , A61K31/428 , C07D401/14 , A61K31/4709 , A61K31/4155 , A61K31/4535 , A61P1/00 , A61P19/02 , A61P3/10 , A61P25/28 , A61P17/06 , A61P37/06 , A61P7/06
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US07906553B2
公开(公告)日：2011-03-15
申请号：US12548189
申请日：2009-08-26
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/38
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds of Formula (I) having the structure: where A, J, R1, R4, Z and X are described herein; and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了具有以下结构的式（I）的化合物：其中A，J，R 1，R 4，Z和X在本文中描述; 和含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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公开(公告)号：US08754219B2
公开(公告)日：2014-06-17
申请号：US13643537
申请日：2011-04-27
申请人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/44 , C07D221/02
CPC分类号： C07D417/12 , C07C233/75 , C07C233/80 , C07C233/92 , C07C255/60 , C07C2601/02 , C07D213/81 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/56 , C07D263/57 , C07D277/34 , C07D277/56 , C07D317/62 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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公开(公告)号：US08618307B2
公开(公告)日：2013-12-31
申请号：US12883014
申请日：2010-09-15
申请人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers
发明人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers
IPC分类号： C07D263/58
CPC分类号： C07D409/12 , C07D333/38 , C07D409/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US08372991B2
公开(公告)日：2013-02-12
申请号：US13050356
申请日：2011-03-17
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： C07D409/00
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds of Formula (I): wherein A, J, Z, X, R1 and R4 are defined herein, and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述的是式（I）的化合物：其中A，J，Z，X，R 1和R 4在本文中定义，以及含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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公开(公告)号：US20110136816A1
公开(公告)日：2011-06-09
申请号：US13006701
申请日：2011-01-14
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/498 , A61K31/433 , A61K31/423 , A61K31/381 , A61K31/428 , A61K31/437 , A61K31/4436 , A61K31/502 , A61P37/06 , A61P37/08 , A61P29/00 , A61P11/06 , A61P21/00 , A61P17/00 , A61P1/16
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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