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    METHODS AND SYSTEMS FOR REMOVING AUTOFLUORESCENCE FROM IMAGES
    31.
    发明申请
    METHODS AND SYSTEMS FOR REMOVING AUTOFLUORESCENCE FROM IMAGES 有权
    从图像中删除自动化的方法和系统

    公开(公告)号：US20090141959A1

    公开(公告)日：2009-06-04

    申请号：US11948205

    申请日：2007-11-30

    申请人： Ali Can ,  Michael John Gerdes ,  Harvey Ellis Cline

    发明人： Ali Can ,  Michael John Gerdes ,  Harvey Ellis Cline

    IPC分类号： G06K9/00

    CPC分类号： G01N21/6458 ,  G01N21/6428 ,  G01N2021/6441

    摘要： Method and systems for removing any inherent autofluorescence associated with a biological material, comprising: acquiring a first reference image of the biological material; acquiring a first set of one or more images of the biological material using one or more filters corresponding to one or more information dyes; applying the one or more additional dyes to the biological material and then acquiring a second set of one or more images comprising a separate image of the biological material with each of the filters corresponding to the information dyes and a second reference image of the biological material; coregistering the first and second reference images; and then removing any inherent autofluorescence exhibited in the informational images acquired.

    摘要翻译： 用于去除与生物材料相关联的任何固有自发荧光的方法和系统，包括：获取所述生物材料的第一参考图像; 使用对应于一种或多种信息染料的一个或多个过滤器获取所述生物材料的第一组一个或多个图像; 将一种或多种另外的染料施加到生物材料上，然后获取包含生物材料的单独图像的第二组一个或多个图像，其中每个滤色器对应于信息染料和生物材料的第二参考图像; 整合第一和第二参考图像; 然后去除所获得的信息图像中显示的任何固有自发荧光。

    Matrix coil for generating a variable magnetic field
    34.
    发明授权
    Matrix coil for generating a variable magnetic field 有权
    用于产生可变磁场的矩阵线圈

    公开(公告)号：US06933724B2

    公开(公告)日：2005-08-23

    申请号：US10719118

    申请日：2003-11-21

    申请人： Ronald Dean Watkins ,  Harvey Ellis Cline ,  Douglas Arthur Kelley

    发明人： Ronald Dean Watkins ,  Harvey Ellis Cline ,  Douglas Arthur Kelley

    IPC分类号： G01R33/38 ,  G01R33/385 ,  G01R33/3875 ,  G01V3/00

    CPC分类号： G01R33/381 ,  G01R33/385 ,  G01R33/3875

    摘要： A matrix coil for generating a variable magnetic field is provided, including a plurality of loops arranged in a series so as to have a substantially common axis and segmented into at least one arc-shaped segment, a variable current source for each of the arc-shaped segments, and a controller. The controller is configured to selectively vary an amount of current provided to each of the arc-shaped segments by the variable current sources so as to achieve a variable base field, one or more variable gradient fields, and one or more variable second order shim fields.

    摘要翻译： 提供了一种用于产生可变磁场的矩阵线圈，包括以串联布置的多个环，以便具有基本共同的轴线并分成至少一个弧形段，用于每个弧形区段的可变电流源， 形状的片段和控制器。 控制器被配置为选择性地改变由可变电流源提供给每个弧形段的电流量，以便实现可变基场，一个或多个可变梯度场，以及一个或多个可变二阶垫片场 。

    Rendering of surfaces from volumetric data employing both dividing and stretching cubes
    35.
    发明授权
    Rendering of surfaces from volumetric data employing both dividing and stretching cubes 失效
    使用分割和拉伸立方体的体积数据渲染表面

    公开(公告)号：US06219060B1

    公开(公告)日：2001-04-17

    申请号：US09173332

    申请日：1998-10-15

    申请人： Siegwalt Ludke ,  Harvey Ellis Cline

    发明人： Siegwalt Ludke ,  Harvey Ellis Cline

    IPC分类号： G06T1700

    CPC分类号： G06T15/08

    摘要： Anisotropic data having data spacing significantly larger between layers of data compared with spacing between adjacent data values, is supplemented with additional data to approximate isometric data. The ratio of spacing in one dimension to another is referred to as an aspect ratio A. Preferably, spacing is halved until spacing a modified aspect ratio A′ is near unity. Intermediate values are interpolated between existing values of the anisotropic data to create approximate isotropic data having a modified aspect ratio A′. Surface voxels are determined from the approximate isotropic data. The values of the adjacent voxels are then used to determine a vector normal to the surface at the central voxel. This is repeated for a number of central voxels to determine a surface. The viewing elevation angle is converted to an effective elevation angle. The surface is then rendered into a 2D screen image as if it were created from isotropic data. The resulting distorted 2D image is then stretched by an amount related to the approximate aspect ratio A′ to result in a high-resolution non-distorted image. The surface then may be displayed.

    摘要翻译： 与相邻数据值之间的间隔相比，各层数据之间的数据间隔显着更大的各向异性数据被补充有附加数据以近似等轴测量数据。 将一个尺寸之间的间距与另一个尺寸的比率称为纵横比A.优选地，将间隔减半，直到修改的纵横比A'接近单位为止。 在各向异性数据的现有值之间插入中间值以创建具有修改的纵横比A'的近似各向同性数据。 表面体素由近似各向同性数据确定。 然后使用相邻体素的值来确定在中心体素处垂直于表面的矢量。 对于许多中心体素重复这一点以确定表面。 视角仰角转换为有效仰角。 然后将表面渲染成2D屏幕图像，就好像它是由各向同性数据创建的。 然后将产生的失真的2D图像拉伸与大致长宽比A'相关的量，以产生高分辨率的非失真图像。 然后可以显示表面。

    Fast segmentation of cardiac images
    36.
    发明授权
    Fast segmentation of cardiac images 失效
    快速分割心脏图像

    公开(公告)号：US5903664A

    公开(公告)日：1999-05-11

    申请号：US794981

    申请日：1997-02-05

    申请人： Richard Ian Hartley ,  Rupert William Meldrum Curwen ,  Harvey Ellis Cline

    发明人： Richard Ian Hartley ,  Rupert William Meldrum Curwen ,  Harvey Ellis Cline

    IPC分类号： A61B5/055 ,  G06T1/00 ,  G06T5/00 ,  G06K9/00

    CPC分类号： G06T7/0081 ,  G06T7/0012 ,  G06T2207/20012 ,  G06T2207/20101 ,  G06T2207/20104 ,  G06T2207/30048

    摘要： A cardiac segmentation system acquires a series of images acquires as slices through a volume, and as images at different time periods throughout a cardiac cycle. It displays an image to an operator which interactively selects a region of interest (ROI) of the image to be segmented, such as the left ventricle. A seed point is also selected within the ROI and the structure desired to be segmented. The image is then thresholded by a masking device classifying points within the ROI as above the threshold, or not above the threshold. A 3D connectivity device identifies points within the ROI having the same classification as an expanded seed point which are also contiguous with the seed point as the segmented structure. The segmented structure is expanded and a histogram is constructed. A new threshold is selected which separates modes of the histogram, and used to carry out a revised, final, segmentation of the current image. The centroid of the current image is used as a seed point in segmenting adjacent images. Similarly, the current threshold is used as an initial threshold for adjacent images. The previous seed point and ROI may also be used. This is repeated for a number of images to result in segmented structures may then be stored, displayed and used in calculating heart functionality.

    摘要翻译： 心脏分割系统通过体积获取作为切片获取的一系列图像，并且获取整个心脏周期中不同时间段的图像。 它向操作者显示图像，其交互地选择要被分割的图像的感兴趣区域（ROI），例如左心室。 还在ROI内选择种子点，并且希望被分割的结构。 然后通过掩蔽装置对图像进行阈值化，将ROI内的点分类为阈值以上，或不高于阈值。 3D连接设备识别ROI内的点与扩展种子点相同的分类，其也与种子点相邻，作为分段结构。 分段结构展开并构建直方图。 选择一个新的阈值，其分离直方图的模式，并用于对当前图像执行经修改的最终分割。 当前图像的质心在分割相邻图像时用作种子点。 类似地，将当前阈值用作相邻图像的初始阈值。 也可以使用先前的种子点和ROI。 对于多个图像重复导致分段结构可以被存储，显示并用于计算心脏功能。

    Ultrasound transducer with focused ultrasound refraction plate
    37.
    发明授权
    Ultrasound transducer with focused ultrasound refraction plate 失效
    超声波换能器与聚焦超声折射板

    公开(公告)号：US5873845A

    公开(公告)日：1999-02-23

    申请号：US818988

    申请日：1997-03-17

    申请人： Harvey Ellis Cline ,  Ronald Dean Watkins ,  George Raymond Russell ,  Kullervo Henrik Hynynen

    发明人： Harvey Ellis Cline ,  Ronald Dean Watkins ,  George Raymond Russell ,  Kullervo Henrik Hynynen

    IPC分类号： A61B17/22 ,  A61B17/225 ,  A61B19/00 ,  A61N7/02 ,  G10K11/30

    CPC分类号： G10K11/30 ,  A61N7/02 ,  A61B2017/22028 ,  A61B2090/374

    摘要： A system for performing surgery by vibrational heating employs an ultrasonic transducer 80 for focusing a spherical ultrasound wave on a focal region. In one embodiment a refraction plate 410 having a spherical surface facing the transducer and a refracting surface with refracting pyramid elements 450 facing the subject causes the ultrasound beam to impinge on a plurality of overlapping focal regions and thereby expand the focal area of the transducer. In a second embodiment the refraction plate comprises a phased lens 600 having a constant thickness at any angular location but with its thickness varying linearly over 2.pi. radians or multiples thereof.

    摘要翻译： 用于通过振动加热进行手术的系统使用用于将球状超声波聚焦在焦点区域上的超声波换能器80。 在一个实施例中，具有面向换能器的球形表面的折射板410和面向被摄体的折射金字塔元件450的折射表面使得超声波束撞击在多个重叠的焦点区域上，从而扩大换能器的焦点区域。 在第二实施例中，折射板包括在任何角度位置具有恒定厚度的相控透镜600，但其厚度在2π弧度或其倍数上线性变化。