公开(公告)号：US20060094667A1

公开(公告)日：2006-05-04

申请号：US11247332

申请日：2005-10-12

申请人： Hideki Fujikura ,  Nobuhiko Fushimi ,  Toshihiro Nishimura ,  Takeshi Nakabayashi ,  Masayuki Isaji

发明人： Hideki Fujikura ,  Nobuhiko Fushimi ,  Toshihiro Nishimura ,  Takeshi Nakabayashi ,  Masayuki Isaji

IPC分类号： A61K31/7052 ,  C07H17/02

CPC分类号： A61K45/06 ,  A61K31/7056 ,  C07H17/02 ,  A61K2300/00

摘要： The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug;.one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo (lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.

摘要翻译： 本发明提供由以下通式表示的吡喃葡萄糖氧吡唑衍生物：其中R表示氢原子，低级烷基或形成前药的基团; Q和T表示由以下通式表示的基团：（其中P表示 氢原子或形成前药的基团），而另一个表示低级烷基或卤代（低级烷基）基团; R 2表示氢原子，低级烷基，低级烷氧基，低级烷硫基，卤代（低级烷基）或卤素原子; 并且条件是当R表示氢原子或低级烷基时，P不表示氢原子，或其药学上可接受的盐，其在人SGLT2中具有抑制活性并具有改善的口服吸收，因此可用作 用于预防或治疗与高血糖相关的疾病如糖尿病，糖尿病并发症或肥胖症的药剂及其药学上可接受的盐及其药学用途。

公开(公告)号：US20060035840A1

公开(公告)日：2006-02-16

申请号：US10540519

申请日：2003-12-19

申请人： Hideki Fujikura ,  Toshihiro Nishimura ,  Kenji Katsuno ,  Masayuki Isaji

发明人： Hideki Fujikura ,  Toshihiro Nishimura ,  Kenji Katsuno ,  Masayuki Isaji

IPC分类号： A61K31/7052 ,  C07H17/02

CPC分类号： C07H17/02 ,  A61K31/706

摘要： The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X1 represents Nor CR1; X2 represents Nor CR2; X3 represents N or CR3; X4 represents N or CR4; and with the proviso that one or two of X1 to X4 represent N; R represents optionally substituted C3-8 cycloalkyl, optionally substituted C6-10 aryl, etc.; R1 to R4 represent H, a halogen atom, etc.) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an excellent inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications, obesity or the like, pharmaceutical compositions comprising the same, and medicinal uses thereof.

摘要翻译： 本发明提供由以下通式表示的含氮杂环衍生物：其中X 1表示Nor CR 1; X <2>表示Nor CR 2; X 3表示N或CR 3; X 4表示N或CR 4; 并且条件是X 1至X 4中的一个或两个表示N; R表示任选取代的C 3-8环烷基，任选取代的C 6-10芳基等; R 1至R 4代表H，卤素原子等）或其药学上可接受的盐或其前药，其在人SGLT2中具有优异的抑制活性，并且为 可用作预防或治疗与高血糖相关的疾病如糖尿病，糖尿病并发症，肥胖症等的药剂，其药物组合物及其药物用途。

公开(公告)号：US07655633B2

公开(公告)日：2010-02-02

申请号：US10540519

申请日：2003-12-19

申请人： Hideki Fujikura ,  Toshihiro Nishimura ,  Kenji Katsuno ,  Masayuki Isaji

发明人： Hideki Fujikura ,  Toshihiro Nishimura ,  Kenji Katsuno ,  Masayuki Isaji

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H15/24

CPC分类号： C07H17/02 ,  A61K31/706

摘要： The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X1 represents N or CR1; X2 represents N or CR2; X3 represents N or CR3; X4 represents N or CR4; and with the proviso that one or two of X1 to X4 represent N; R represents optionally substituted C3-8 cycloalkyl, optionally substituted C6-10 aryl, etc.; R1 to R4 represent H, a halogen atom, etc.) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an excellent inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications, obesity or the like, pharmaceutical compositions comprising the same, and medicinal uses thereof.

摘要翻译： 本发明提供由以下通式表示的含氮杂环衍生物：其中X1表示N或CR1; X2表示N或CR2; X3表示N或CR3; X4表示N或CR4; 并且条件是X1至X4中的一个或两个表示N; R代表任选取代的C 3-8环烷基，任选取代的C 6-10芳基等; R1至R4表示H，卤素原子等）或其药学上可接受的盐或其前药，其在人SGLT2中具有优异的抑制活性，并且可用作预防或治疗与高血糖相关的疾病的药剂，例如 糖尿病，糖尿病并发症，肥胖症等，包含其的药物组合物及其药用用途。

公开(公告)号：USD632623S1

公开(公告)日：2011-02-15

申请号：US29367634

申请日：2010-08-10

申请人： Toshihiro Nishimura

设计人： Toshihiro Nishimura

公开(公告)号：US20070032601A1

公开(公告)日：2007-02-08

申请号：US10572385

申请日：2004-09-17

申请人： Tsutomu Tasaki ,  Toshihiro Nishimura ,  Hiroshi Inoue

发明人： Tsutomu Tasaki ,  Toshihiro Nishimura ,  Hiroshi Inoue

IPC分类号： C08L23/04

CPC分类号： C08J5/18 ,  C08J2323/06 ,  C08J2323/08 ,  Y10S428/91 ,  Y10T428/31855 ,  Y10T428/31938

摘要： The present invention relates to a polyethylene-based stretched film having excellent Elmendorf tear strength and uniform stretchability. The invention relates to a polyethylene-based stretched film which is obtained by stretching a polyethylene-based resin, wherein (A-i) Em and Et, which represent the values of Elmendorf tear strength in the MD and TD directions, respectively, as measured in accordance with ASTM D1922, satisfy the following formulas 1, 2 and 3: 20≦Em[N/m]≦3000  (Formula 1) 20≦Et[N/m]≦3000  (Formula 2) 0.1≦(Em/Et)≦3  (Formula 3); (a-ii) the tensile initial modulus TM in the MD direction satisfies the following formula 4: 300≦TM[MPa]≦10000  (Formula 4); and (a-iii) the thickness is in the range of 5 to 150 μm, and is excellent in the stretch uniformity.

摘要翻译： 本发明涉及具有优异的埃尔门多夫撕裂强度和均匀拉伸性的聚乙烯基拉伸膜。 本发明涉及通过拉伸聚乙烯类树脂而获得的聚乙烯基拉伸膜，其中（Ai）Em和Et分别代表根据MD和TD方向的埃尔曼多夫撕裂强度值 与ASTM D1922相符合下列公式1,2和3：<？in-line-formula description =“In-line formula”end =“lead”？> 20 <= Em [N / m] <= 3000 1）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line formula”end =“lead”？> 20 <= Et [N / m] <= 3000（公式2）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“铅”？> 0.1 <=（Em / Et）<= 3（式3）; （a-ii）MD方向上的拉伸初始模量TM满足下列公式4：<？在线公式描述=“直线公式”end =“tail” =“在线公式”end =“lead”？> 300 <= TM [MPa] <= 10000（公式4）; <？in-line-formula description =“In-line Formulas”end =“tail”？>和（a-iii）厚度在5至150μm的范围内，并且拉伸均匀性优异。

公开(公告)号：US06803423B2

公开(公告)日：2004-10-12

申请号：US10171535

申请日：2002-06-17

申请人： Toshiyuki Hayakawa ,  Toshihiro Nishimura ,  Motoharu Higuchi ,  Minoru Tanaka ,  Shoei Tsuji

发明人： Toshiyuki Hayakawa ,  Toshihiro Nishimura ,  Motoharu Higuchi ,  Minoru Tanaka ,  Shoei Tsuji

IPC分类号： C08F25502

CPC分类号： C08F8/00 ,  C08F2800/10 ,  C08F2810/20 ,  C08F2810/30 ,  C08F2810/50 ,  C08F210/16 ,  C08F210/02

摘要： An (meth)acryloyl group-modified ethylene-&agr;-olefin copolymer (A) which has (meth)acryloyl group as a the side-chain thereof, wherein the intrinsic viscosity [&eegr;] was 0.01 to 10 dl/g measured in decalin at a temperature of 135° C.; and a rubber composition which comprises said (meth)acryloyl group-modified ethylene-&agr;-olefin copolymer, a vulcanizing agent, and/or a crosslinking agent; in addition, a liquid curable rubber composition which comprises, component (A), reactive diluent (D), and if necessary, photopolymerization initiator (E).

摘要翻译： 作为侧链具有（甲基）丙烯酰基的（甲基）丙烯酰基改性乙烯-α-烯烃共聚物（A），其特性粘度η为0.01〜10dl / g，在十氢化萘中测定 温度为135℃。 和包含所述（甲基）丙烯酰基改性乙烯-α-烯烃共聚物，硫化剂和/或交联剂的橡胶组合物; 另外，含有组分（A），反应性稀释剂（D）以及如果需要的光聚合引发剂（E）的液体可固化橡胶组合物。

公开(公告)号：US5756193A

公开(公告)日：1998-05-26

申请号：US623147

申请日：1996-03-28

申请人： Akihiko Yamamoto ,  Naoshi Hamada ,  Toshihiro Nishimura ,  Kouji Kitahara

发明人： Akihiko Yamamoto ,  Naoshi Hamada ,  Toshihiro Nishimura ,  Kouji Kitahara

IPC分类号： B65D30/02 ,  B65D30/10 ,  C08F4/642 ,  C08J5/18 ,  C08L23/00 ,  C08L23/04 ,  C08L23/06 ,  C08L23/08

CPC分类号： C08L23/0815 ,  C08L2205/02 ,  C08L2205/03 ,  C08L2205/035 ,  C08L23/06

摘要： Disclosed is a polyethylene resin composition for heavy-duty packaging bag, which has a specific MFR, a specific density and a specific melt tension and which comprises (I) a linear low-density polyethylene resin prepared from ethylene and an .alpha.-olefin of 4 or more carbon atoms and having a specific MFR, a specific molecular weight distribution and a density of 0.900 to 0.918 g/cm.sup.3, (II) a linear medium or high-density polyethylene resin having a density of 0.935 to 0.970 g/cm.sup.3 and (III) a high-pressure low-density polyethylene resin having a density of 0.915 to 0.924 g/cm.sup.3, in a specific ratio of components. Also disclosed is a polyethylene resin film prepared from said composition. The composition is able to provide a film which is excellent in low-temperature properties such as low-temperature drop-bag strength and can be advantageously used for a heavy-duty packaging bag even in a cold district of below-freezing temperature. The polyethylene resin film exerts the above-mentioned effects.

摘要翻译： 公开了一种用于重型包装袋的聚乙烯树脂组合物，其具有特定的MFR，比重密度和特定的熔体张力，并且包括（I）由乙烯和α-烯烃制备的线性低密度聚乙烯树脂 或更多的碳原子，并且具有特定的MFR，特定的分子量分布和0.900至0.918g / cm 3的密度，（II）密度为0.935至0.970g / cm3的线性介质或高密度聚乙烯树脂和（ III）以特定比例的组分密度为0.915至0.924g / cm 3的高压低密度聚乙烯树脂。 还公开了由所述组合物制备的聚乙烯树脂膜。 该组合物能够提供低温下降袋强度等低温性能优异的膜，即使在低于冰点的低温区域也能够有利地用于重型包装袋。 聚乙烯树脂膜发挥上述效果。

公开(公告)号：US5539811A

公开(公告)日：1996-07-23

申请号：US226591

申请日：1994-04-12

申请人： Junji Nakamura ,  Toshihiro Nishimura

发明人： Junji Nakamura ,  Toshihiro Nishimura

IPC分类号： H04M3/56 ,  H04M11/00 ,  H04N7/14 ,  H04Q11/04 ,  H04N7/12

CPC分类号： H04Q11/0428 ,  H04N7/147 ,  H04N7/148 ,  H04Q2213/13034 ,  H04Q2213/1307 ,  H04Q2213/13097 ,  H04Q2213/13204 ,  H04Q2213/13208 ,  H04Q2213/13209 ,  H04Q2213/13216 ,  H04Q2213/13292 ,  H04Q2213/13337 ,  H04Q2213/13367

摘要： A visual communication is performed between a calling party and a called party through a plurality of channels. After the parties are connected through a first channel, an available telephone number of a second channel stored in a BAS control portion is read to a TNI control portion on each of the parties, and the TNI control portions of the parties exchange the available telephone numbers. Thereafter, when an incoming call having a telephone number is received through the second channel by a call control processing portion of the called party, the telephone number of the call is compared with the available telephone number of the second channel by an ICJ portion. To perform correct visual communication between parties, in cases where the telephone number of the call agrees with the available telephone number, the call is established by the call control processing portion, and image and audio signals are transmitted from the calling party to the called party through codec portions, multiplexing/demultiplexing portions and the first and second channels to perform a visual communication. In contrast, in cases where the telephone number of the call does not agree with the available telephone number, the second channel is released.

摘要翻译： 通过多个信道在呼叫方和被叫方之间进行可视通信。 在通过第一信道连接各方之后，存储在BAS控制部分中的第二信道的可用电话号码被读取到每个方的TNI控制部分，并且各方的TNI控制部分交换可用的电话号码 。 此后，当通过被叫方的呼叫控制处理部分通过第二信道接收到具有电话号码的呼入时，通过ICJ部分将呼叫的电话号码与第二频道的可用电话号码进行比较。 为了在各方之间进行正确的视觉通信，在呼叫的电话号码与可用的电话号码一致的情况下，由呼叫控制处理部分建立呼叫，并且将图像和音频信号从呼叫方发送到被叫方 通过编解码部分，复用/解复用部分和第一和第二信道来执行视觉通信。 相反，在呼叫的电话号码与可用的电话号码不一致的情况下，第二频道被释放。

公开(公告)号：US4868096A

公开(公告)日：1989-09-19

申请号：US92485

申请日：1987-09-03

申请人： Muneo Nakayama ,  Akira Uehara ,  Akira Hashimoto ,  Toshihiro Nishimura ,  Isamu Hijikata ,  Mitsuaki Minato ,  Eiichi Kashiwagi

发明人： Muneo Nakayama ,  Akira Uehara ,  Akira Hashimoto ,  Toshihiro Nishimura ,  Isamu Hijikata ,  Mitsuaki Minato ,  Eiichi Kashiwagi

IPC分类号： G03F7/11

CPC分类号： G03F7/11

摘要： The adhesiveness of a silicone-based coating film on a substrate to an overcoating layer, e.g., a photoresist layer, can be improved without causing cracks when the silicone-based coating film is subjected to a plasma treatment at a temperature of 120.degree. C. or below in an atmosphere of a gas mainly composed of oxygen. Similar conditions of plasma treatment are applicable when patterning of a silicone-based coating film is desired in a procedure comprising the steps of forming a photoresist layer thereon, patterning of the photoresist layer in a photolithographic method, selectively etching the silicone-based coating film with the patterned resist layer serving as a mask and removing the photoresist layer by the plasma treatment.

摘要翻译： 当将硅氧烷基涂膜在120℃的温度下进行等离子体处理时，可以改善基材上的硅酮基涂膜与外涂层（例如光致抗蚀剂层）的粘附性，而不引起裂纹。 在主要由氧组成的气体的气氛中。 等离子体处理的类似条件适用于当在包括以下步骤的步骤中需要对硅氧烷基涂膜进行图案化的步骤时，在其上形成光致抗蚀剂层，以光刻方法对光刻胶层进行图案化，选择性地蚀刻硅氧烷基涂膜 图案化的抗蚀剂层用作掩模并通过等离子体处理去除光致抗蚀剂层。

公开(公告)号：US4828906A

公开(公告)日：1989-05-09

申请号：US093206

申请日：1987-09-04

申请人： Toshihiro Nishimura ,  Takashi Matsunaga

发明人： Toshihiro Nishimura ,  Takashi Matsunaga

IPC分类号： A01G13/00 ,  A01G13/02 ,  C08J5/18 ,  C08L23/00 ,  C08L23/08 ,  C08L23/14 ,  C08L23/18

CPC分类号： A01G13/0275 ,  C08L23/0815 ,  C08L2205/02

摘要： A film suitable for an agricultural covering material is formed from a resin composition comprising a blend comprising (A) an ethylene/.alpha.-olefin random copolymer having a low melt flow rate and (B) an ethylene/.alpha.-olefin copolymer having a high melt flow rate. The random copolymer (A) has a density (D.sub.A) of 0.935 to 0.950 g/cc and the random copolymer (B) has a density (D.sub.B) of 0.905 to 0.935 g/cc, and the density (D.sub.B) of the random copolymer (B) satisfies the requirement of D.sub.B .ltoreq.0.9D.sub.A +0.09 in which D.sub.A stands for the density of the copolymer (A).

摘要翻译： 适用于农业覆盖材料的膜由包含（A）具有低熔体流动速率的乙烯/α-烯烃无规共聚物和（B）具有高熔体的乙烯/α-烯烃共聚物的共混物的树脂组合物形成 流量。 无规共聚物（A）的密度（DA）为0.935〜0.950g / cc，无规共聚物（B）的密度（DB）为0.905〜0.935g / cc，无规共聚物 （B）满足DB